Issue 57, 2022

An Fe-based single-atom nanozyme with multi-enzyme activity for parallel catalytic therapy via a cascade reaction

Abstract

Here, we report Fe-based single-atom nanozymes, which were fabricated by embedding Fe atoms into N-doped hollow carbon spheres. The nanozymes (FeSA-HNCSB) exhibit the efficient catalytic generation of ROS in the tumor microenvironment (TME). They possess multiple enzyme-mimicking activities, including catalase-like, oxidase-like, and peroxidase-like activities. Furthermore, the FeSA-HNCSB nanozymes also exhibit good photothermal conversion efficiency in the near-infrared (NIR) region, making them potential candidates for photothermal therapy (PTT) and photothermal-enhanced catalytic therapy. This work provides a new paradigm for integrating parallel catalytic therapy and PTT to improve the effectiveness of tumor treatment.

Graphical abstract: An Fe-based single-atom nanozyme with multi-enzyme activity for parallel catalytic therapy via a cascade reaction

Supplementary files

Article information

Article type
Communication
Submitted
26 5 2022
Accepted
13 6 2022
First published
14 6 2022

Chem. Commun., 2022,58, 7924-7927

An Fe-based single-atom nanozyme with multi-enzyme activity for parallel catalytic therapy via a cascade reaction

R. Niu, Y. Liu, Y. Wang and H. Zhang, Chem. Commun., 2022, 58, 7924 DOI: 10.1039/D2CC02975H

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