Issue 15, 2022

Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases

Abstract

Colorectal cancer is the third most common malignancy that leads to significant mortality around the world. Chronic colonic inflammation could induce a protumor effect by the massive release of pro-inflammatory cytokines, facilitating migration, invasion, and metastasis of malignant cells in colorectal cancer. Therefore, developing a combination regimen of anti-inflammation and antitumor therapies is a promising strategy for the treatment of colorectal cancer. Here, we report that tannic acid-containing nanoparticles, formed by a turbulent-mixing technique, have exhibited uniform size, high stability, and pH-triggered drug release in the gastrointestinal tract, and could overcome intestinal mucosa for drug delivery in the colorectal region. As a drug carrier itself, with potent antioxidant and anti-inflammatory properties, tannic acid-containing nanoparticles showed great therapeutic effect in preventing the development of colitis-associated colorectal cancer (CAC) through oral administration. Furthermore, we used a therapeutic nanocarrier to deliver chemotherapeutic drugs for CAC treatment, generating lower systemic toxicity and superior antitumor performance through concurrent anti-inflammation and antitumor treatment. As a result, we confirmed that the drug carrier itself with therapeutic function could improve the overall therapeutic performance, and provided a safe and effective tannic acid-containing nanoplatform for the prevention and treatment of colon diseases.

Graphical abstract: Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases

Supplementary files

Article information

Article type
Paper
Submitted
08 4 2022
Accepted
26 5 2022
First published
06 6 2022

Biomater. Sci., 2022,10, 4156-4169

Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases

Z. Le, Z. He, H. Liu, J. Ke, L. Liu, Z. Liu and Y. Chen, Biomater. Sci., 2022, 10, 4156 DOI: 10.1039/D2BM00540A

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