Issue 39, 2021

Recent advances in rhodium-catalyzed C(sp2)–H (hetero)arylation

Abstract

Arylation is a common behaviour in organic synthesis for the construction of complex structures, especially the biaryls. Among those reported arylation procedures, transition-metal-catalyzed direct C(sp2)–H arylation has been rapidly developed in recent decades and has become a reliable alternative to traditional cross-coupling procedures using organometallic reagents. Great achievements in rhodium-catalyzed C(sp2)–H arylation have been witnessed during the last decade. Aryl halides, simple arenes, aryl boronic acids, arylsilanes, aryl aldehyde, aryl carboxylic acid, diazides, etc. were successfully utilized as arylating reagents under rhodium-catalyzed conditions. In this review, recent achievements in rhodium-catalyzed arylations through C(sp2)–H bond activation were summarized together with the mechanism discussions.

Graphical abstract: Recent advances in rhodium-catalyzed C(sp2)–H (hetero)arylation

Article information

Article type
Review Article
Submitted
20 6 2021
Accepted
02 9 2021
First published
02 9 2021

Org. Biomol. Chem., 2021,19, 8442-8465

Recent advances in rhodium-catalyzed C(sp2)–H (hetero)arylation

Z. Yang, J. Yu and C. Pan, Org. Biomol. Chem., 2021, 19, 8442 DOI: 10.1039/D1OB01190A

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