Issue 39, 2021

Multicomponent crystals of an artemisinin derivative and cinchona alkaloids for use as antimalarial drugs

Abstract

Pharmaceutical multicomponent crystals (MCCs) including salts and co-crystals of active pharmaceutical ingredients (APIs), are an active focus of research to improve various physicochemical properties of drugs. In this work, we demonstrate that the pharmaceutical artesunate (AS), a derivative of artemisinin (ART), forms a 1 : 1 salt with two cinchona alkaloids: quinine (QN) and cinchonidine (CND), representing the first report of MCCs combining two major types of antimalarial drugs.

Graphical abstract: Multicomponent crystals of an artemisinin derivative and cinchona alkaloids for use as antimalarial drugs

Supplementary files

Article information

Article type
Communication
Submitted
26 7 2021
Accepted
19 8 2021
First published
19 8 2021

CrystEngComm, 2021,23, 6843-6847

Multicomponent crystals of an artemisinin derivative and cinchona alkaloids for use as antimalarial drugs

Q. Jiang, D. A. Hirsh, Y. Tu and L. Luo, CrystEngComm, 2021, 23, 6843 DOI: 10.1039/D1CE00974E

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