Issue 6, 2019

Recent advances in transition metal-catalyzed C(sp2)–H nitration

Abstract

Nitroaromatic compounds play an important role in organic synthesis, medicinal chemistry and chemical industry. Among the recently reported synthetic methods to access nitroarenes, transition metal-catalyzed C(sp2)–H activation/nitration has become one of the most attractive protocols, showing high regioselectivity, excellent functional group tolerance and step-economy. In this review, we discuss advances in direct C(sp2)–H nitration for the synthesis of nitroaromatic compounds and mechanistic insights over the past decade. We hope this will provide valuable information for researchers interested in the rapidly developing field of metal-catalyzed C(sp2)–H nitration.

Graphical abstract: Recent advances in transition metal-catalyzed C(sp2)–H nitration

Article information

Article type
Review Article
Submitted
06 11 2018
Accepted
02 1 2019
First published
03 1 2019

Org. Biomol. Chem., 2019,17, 1351-1361

Recent advances in transition metal-catalyzed C(sp2)–H nitration

L. Song, Z. Fan and A. Zhang, Org. Biomol. Chem., 2019, 17, 1351 DOI: 10.1039/C8OB02750A

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