Issue 15, 2018

Liquid–liquid phase coexistence in lipid membranes observed by natural abundance 1H–13C solid-state NMR

Abstract

We demonstrate that 1H–13C solid-state MAS NMR is suitable to detect liquid disordered/liquid ordered phase coexistence in a DOPC/DPPC/cholesterol mixture with natural abundance of isotopes as an alternative to 2H NMR. Such methodology is potentially applicable to study lipid phase coexistence phenomena in biological matter with high lipid content, e.g. lung surfactant or myelin, for which isotopic labeling is not possible.

Graphical abstract: Liquid–liquid phase coexistence in lipid membranes observed by natural abundance 1H–13C solid-state NMR

Supplementary files

Article information

Article type
Communication
Submitted
12 2 2018
Accepted
13 3 2018
First published
13 3 2018

Phys. Chem. Chem. Phys., 2018,20, 9751-9754

Liquid–liquid phase coexistence in lipid membranes observed by natural abundance 1H–13C solid-state NMR

L. Löser, K. Saalwächter and T. Mendes Ferreira, Phys. Chem. Chem. Phys., 2018, 20, 9751 DOI: 10.1039/C8CP01012A

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