Issue 10, 2017

Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent

Abstract

The first example of a silver-mediated fluorination of alkyl iodides with the Ruppert–Prakash reagent (TMSCF3) as a fluorinating agent has been reported. This reaction is compatible with a variety of functional groups and proceeds under mild reaction conditions. Moreover, we demonstrate that the large surface area of CaF2 dramatically increased the reaction yield.

Graphical abstract: Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent

Supplementary files

Article information

Article type
Research Article
Submitted
08 6 2017
Accepted
26 6 2017
First published
27 6 2017

Org. Chem. Front., 2017,4, 1958-1961

Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent

L. Wang, X. Jiang and P. Tang, Org. Chem. Front., 2017, 4, 1958 DOI: 10.1039/C7QO00450H

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