Issue 7, 2017

The synergistic effect between KLVFF and self-assembly chaperones on both disaggregation of beta-amyloid fibrils and reducing consequent toxicity

Abstract

By combining KLVFF peptide and self-assembly chaperone we fabricate a new system to achieve the synchronization between Aβ fibril disaggregation and reducing toxicity of Aβ fragments (monomers or oligomers) that consequently formed. When the KLVFF peptides disaggregate fibrils into fragments, the hydrophobic domains of self-assembly chaperones promptly bind them at the same time. This binding blocks the re-aggregation of the fragments and their interaction with cells, and hence reduces the toxicity of these dangerous fragments.

Graphical abstract: The synergistic effect between KLVFF and self-assembly chaperones on both disaggregation of beta-amyloid fibrils and reducing consequent toxicity

Supplementary files

Article information

Article type
Communication
Submitted
26 9 2016
Accepted
19 12 2016
First published
21 12 2016

Chem. Commun., 2017,53, 1289-1292

The synergistic effect between KLVFF and self-assembly chaperones on both disaggregation of beta-amyloid fibrils and reducing consequent toxicity

A. Qu, F. Huang, A. Li, H. Yang, H. Zhou, J. Long and L. Shi, Chem. Commun., 2017, 53, 1289 DOI: 10.1039/C6CC07803F

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