Issue 7, 2015

Persulfides: current knowledge and challenges in chemistry and chemical biology

Abstract

Recent studies conducted in hydrogen sulfide (H2S) signaling have revealed potential importance of persulfides (RSSH) in redox biology. The inherent instability of RSSH makes these species difficult to study and sometimes controversial results are reported. In this review article we summarize known knowledge about both small molecule persulfides and protein persulfides. Their fundamental physical and chemical properties such as preparation/formation and reactivity are discussed. The biological implications of persulfides and their detection methods are also discussed.

Graphical abstract: Persulfides: current knowledge and challenges in chemistry and chemical biology

Article information

Article type
Review Article
Submitted
28 3 2015
Accepted
04 5 2015
First published
07 5 2015

Mol. BioSyst., 2015,11, 1775-1785

Author version available

Persulfides: current knowledge and challenges in chemistry and chemical biology

C. Park, L. Weerasinghe, J. J. Day, J. M. Fukuto and M. Xian, Mol. BioSyst., 2015, 11, 1775 DOI: 10.1039/C5MB00216H

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