Issue 35, 2009

Efficient syntheses of α-pyridones and 3(2H)-isoquinolones through ruthenium-catalyzed cycloisomerization of 3-en-5-ynyl and o-alkynylphenyl nitrones

Abstract

We report a new catalytic synthesis of α-pyridones and 3(2H)-isoquinolones from readily available 3-en-5-ynyl nitrones and o-alkynylphenyl nitrones; the reaction mechanism is proposed to involve iminyl ketene species through an oxygen transfer process.

Graphical abstract: Efficient syntheses of α-pyridones and 3(2H)-isoquinolones through ruthenium-catalyzed cycloisomerization of 3-en-5-ynyl and o-alkynylphenyl nitrones

Supplementary files

Article information

Article type
Communication
Submitted
02 6 2009
Accepted
16 7 2009
First published
06 8 2009

Chem. Commun., 2009, 5233-5235

Efficient syntheses of α-pyridones and 3(2H)-isoquinolones through ruthenium-catalyzed cycloisomerization of 3-en-5-ynyl and o-alkynylphenyl nitrones

K. Pati and R. Liu, Chem. Commun., 2009, 5233 DOI: 10.1039/B910773H

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