Editorial
Introduction to Biomaterials in Innate Immunity
Erika Moore and Shreya A Raghavan introduce the Journal of Materials Chemistry B and Materials Advances joint themed issue on Biomaterials in Innate Immunity.
Perspective
Single-cell analysis of innate immune cell mechanics: an application to cancer immunology
Alterations in the tumor microenvironment not only modulate cancer cell progression and invasiveness but also affect the viscoelastic properties of immune cells therein.
Review Article
Cell dynamics and metabolism of the foreign body response: characterizing host-biomaterial interactions for next-generation medical implant biocompatibility
Profiling cellular metabolism in the FBR could identify novel therapeutic targets and promote biocompatibility.
Review Article
Biomaterial strategies for regulating the neuroinflammatory response
This review highlights recent breakthroughs in biomaterial-based strategies for modulating neuroinflammation in central nervous system injury and disease, including nanoparticles, hydrogels, neural probe coatings, and implantable scaffolds.
Harnessing biomaterial architecture to drive anticancer innate immunity
Structure-driven immunomodulatory biomaterial design enhances innate immune activation against the tumor microenvironment to drive anticancer immunity.
Engineering in vitro models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials
The release and accumulation of neutrophil extracellular traps (NETs) in the airway mucus barrier is prominent in cystic fibrosis. New biomaterial-based models are developed that mimic important aspects of NET-mediated pathobiology in cystic fibrosis.
Galactomannan-graft-poly(methyl methacrylate) nanoparticles induce an anti-inflammatory phenotype in human macrophages
Macrophages are immune cells that can be activated into either pro-inflammatory M1 or anti-inflammatory M2 phenotypes.
About this collection
Guest Edited by Erika Moore (University of Maryland, USA) and Shreya Raghavan (Texas A&M University, USA). This collection focuses on the application of biomaterials engineered to study innate immune function or modulate phenotypes of immune cells in regeneration and disease. Covering advances in the engineering of biomaterials in cancer, regeneration/wound healing, auto-immunity/trained immunity, and vaccines targeting the innate immune system.