Themed collection 2023 Chemical Science HOT Article Collection
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Challenges in the design and synthesis of self-assembling molecules as selective contacts in perovskite solar cells
We summarize the challenges to design and synthesize self-assembled molecules, discussing their synthetic routes and structural features in relationship to the efficiency of perovskite-based solar cells where they are applied as selective contacts.
Chem. Sci., 2024,15, 1534-1556
https://doi.org/10.1039/D3SC04668K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Precise activation of C–C bonds for recycling and upcycling of plastics
The critical task of activating and cleaving inert C–C bonds during plastic upcycling and recycling holds substantial importance.
Chem. Sci., 2024,15, 795-831
https://doi.org/10.1039/D3SC05701A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Improved transition metal photosensitizers to drive advances in photocatalysis
This perspective focuses on strategies to manipulate and optimize three key determinants of metal-based molecular photosensitizers – the absorption profile, the excited-state redox potentials, and the excited-state lifetime.
Chem. Sci., 2024,15, 77-94
https://doi.org/10.1039/D3SC04580C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Development and application of decatungstate catalyzed C–H 18F- and 19F-fluorination, fluoroalkylation and beyond
We describe our efforts to develop a decatungstate (DT)-catalyzed C–H 18F- and 19F-fluorination reaction, and the discovery and exploitation of electrostatic effects in DT catalysis for the synthesis of radiotracers for PET imaging.
Chem. Sci., 2023,14, 12883-12897
https://doi.org/10.1039/D3SC04027E
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Picking the lock of coordination cage catalysis
We provide an overview of coordination cage catalysis, highlighting how mechanistic understanding can help address the challenges in this area leading to new opportunities in non-covalent reactivity.
Chem. Sci., 2023,14, 11300-11331
https://doi.org/10.1039/D3SC02586A
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Control of electronic polarization via charge ordering and electron transfer: electronic ferroelectrics and electronic pyroelectrics
Advances in molecular electronic ferroelectrics are summarized. In addition, electronic pyroelectrics using electron transfer is introduced as a promising alternative in the development of polarization switching materials.
Chem. Sci., 2023,14, 10631-10643
https://doi.org/10.1039/D3SC03432A
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The rise of automated curiosity-driven discoveries in chemistry
The quest for generating novel chemistry knowledge is critical in scientific advancement, and machine learning (ML) has emerged as an asset in this pursuit.
Chem. Sci., 2023,14, 10378-10384
https://doi.org/10.1039/D3SC03367H
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Transition-metal (oxy)nitride photocatalysts for water splitting
This perspective highlights recent advances and challenges in transition-metal (oxy)nitrides, which are promising photocatalysts for overall water splitting, and discusses opportunities to upgrade the solar-to-hydrogen energy conversion efficiency.
Chem. Sci., 2023,14, 9248-9257
https://doi.org/10.1039/D3SC03198E
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Impact of core–shell perovskite nanocrystals for LED applications: successes, challenges, and prospects
Using core/shell based perovskite materials is a promising strategy to stabilize perovskite nanocrystal phases and passivate the surface, in order to improve both the stability and the optical properties of the material and in turn of light emitting diodes.
Chem. Sci., 2023,14, 8984-8999
https://doi.org/10.1039/D3SC02955G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Opportunities and challenges of protein-based targeted protein degradation
Targeted protein degradation strategies employing proteins as binders for degradation targets.
Chem. Sci., 2023,14, 8433-8447
https://doi.org/10.1039/D3SC02361C
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Metallated dihydropyridinates: prospects in hydride transfer and (electro)catalysis
Hydride transfer (HT) is a fundamental step in a wide range of reaction pathways, including those mediated by dihydropyridinates (DHP−s).
Chem. Sci., 2023,14, 8234-8248
https://doi.org/10.1039/D3SC02080K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Resurgence and advancement of photochemical hydrogen atom transfer processes in selective alkane functionalizations
By drawing inspiration from photoredox catalysis, the field of radical-mediated alkane functionalization has made remarkable advancements recently to address the challenges of today and future.
Chem. Sci., 2023,14, 6841-6859
https://doi.org/10.1039/D3SC01118F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Redox catalysis via photoinduced electron transfer
This perspective article highlights redox catalysis of organic molecules via photoinduced electron transfer, which is well exploited for the important photoredox reactions including hydrogen evolution, water oxidation and synthetic applications.
Chem. Sci., 2023,14, 4205-4218
https://doi.org/10.1039/D2SC07101K
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Insights into alloy/oxide or hydroxide interfaces in Ni–Mo-based electrocatalysts for hydrogen evolution under alkaline conditions
The activity of Ni–Mo catalysts for the hydrogen evolution reaction originates from the interfaces of alloy–oxide or alloy–hydroxide, in which the oxide or hydroxide promotes water dissociation and the alloy accelerates hydrogen combination.
Chem. Sci., 2023,14, 3400-3414
https://doi.org/10.1039/D2SC06298D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Synchrotron radiation based operando characterization of battery materials
Synchrotron radiation enables probing a wide range of length scales operando, hence being a powerful tool in battery research. Challenges ahead involve cell design (especially for multi-modal approaches) and protocols for automated data analysis.
Chem. Sci., 2023,14, 1641-1665
https://doi.org/10.1039/D2SC04397A
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Back to the future of organolanthanide chemistry
By taking inspiration from the structures and reactivities of its past, organolanthanide chemistry has managed to reinvent itself for the challenges of today and the future.
Chem. Sci., 2023,14, 443-457
https://doi.org/10.1039/D2SC05976B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Polyoxometalate–peptide hybrid materials: from structure–property relationships to applications
Organo-functionalisation of polyoxometalates with peptide moieties is an effective approach to obtain diverse arrays of functional hybrid materials, where each component influences the resulting change, surface chemistry, polarity, and redox properties.
Chem. Sci., 2023,14, 10-28
https://doi.org/10.1039/D2SC05105B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Transformations of carbohydrate derivatives enabled by photocatalysis and visible light photochemistry
This review article highlights the diverse ways in which recent developments in the areas of photocatalysis and visible light photochemistry are impacting synthetic carbohydrate chemistry.
Chem. Sci., 2024,15, 1204-1236
https://doi.org/10.1039/D3SC05400D
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Fluorescence-readout as a powerful macromolecular characterisation tool
We discuss the current state-of-the-art in exploiting fluorescence-based techniques for analysing polymer systems and soft matter materials, as well as provide an outlook on future opportunities and challenges.
Chem. Sci., 2023,14, 12815-12849
https://doi.org/10.1039/D3SC04052F
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Liquid electrolyte chemistries for solid electrolyte interphase construction on silicon and lithium-metal anodes
This review comprehensively summarizes the key features of existing liquid electrolyte formulations for Si and Li metal anodes and proposes design rules for advanced liquid electrolyte chemistry.
Chem. Sci., 2023,14, 9996-10024
https://doi.org/10.1039/D3SC03514J
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Imprinting of nanoparticles in thin films: Quo Vadis?
The combination of molecular imprinting approaches and nanomaterials has recently emerged in new approaches for the imprinting of nanomaterials. This review summarizes the latest studies and the potential implications and applications of this field.
Chem. Sci., 2023,14, 9630-9650
https://doi.org/10.1039/D3SC02178E
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Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues
This review covers recent progress in tyrosine-selective cleavage, functionalization, and conjugation of peptides and proteins. Key applications of Tyr modification are highlighted, demonstrating its great potential for chemistry and biology.
Chem. Sci., 2023,14, 7782-7817
https://doi.org/10.1039/D3SC02543H
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Recent advances in permeable polymersomes: fabrication, responsiveness, and applications
This work reviewed recent advances in the design, fabrication, and responsiveness of permeable polymersomes, and their diverse applications in the fields of biomimetic nanoreactors, artificial cells and organelles, as well as nanomedicine were highlighted.
Chem. Sci., 2023,14, 7411-7437
https://doi.org/10.1039/D3SC01707A
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Circularity in polymers: addressing performance and sustainability challenges using dynamic covalent chemistries
This review provides a multidisciplinary overview of the challenges and opportunities for dynamic covalent chemistry-based macromolecules towards the design of new, sustainable, and recyclable materials for a circular economy.
Chem. Sci., 2023,14, 5243-5265
https://doi.org/10.1039/D3SC00551H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations
A primer that covers the discovery and validation process for novel aptamers and highlights recent applications of aptamers in biosensing and cell separations.
Chem. Sci., 2023,14, 4961-4978
https://doi.org/10.1039/D3SC00439B
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A field guide to flow chemistry for synthetic organic chemists
This review explores the benefits of flow chemistry and dispels the notion that it is a mysterious “black box”, demonstrating how it can push the boundaries of organic synthesis through the understanding of its governing principles.
Chem. Sci., 2023,14, 4230-4247
https://doi.org/10.1039/D3SC00992K
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Conductive hydrogels for tissue repair
This work reviewed the new progress of conductive hydrogels in the application of tissue repair and provided a useful reference for further preparation of safer and more efficient conductive hydrogels for tissue engineering.
Chem. Sci., 2023,14, 3091-3116
https://doi.org/10.1039/D3SC00145H
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Inorganic-based biomaterials for rapid hemostasis and wound healing
This review provides the recent progress in the application of inorganic-based biomaterials for rapid hemostasis and wound healing, including preparation methods, material systems, intrinsic mechanisms and biofunctions.
Chem. Sci., 2023,14, 29-53
https://doi.org/10.1039/D2SC04962G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Transfer learning for a foundational chemistry model
Harnessing knowledge from crystal structures yields a model that can predict a variety of chemistry-relevant outcomes.
Chem. Sci., 2024,15, 5143-5151
https://doi.org/10.1039/D3SC04928K
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Speciation and kinetics of fluoride transfer from tetra-n-butylammonium difluorotriphenylsilicate (‘TBAT’)
19F NMR analysis of ion-pairing and reaction kinetics shows that TBAT can act as a genuine surrogate for TBAF, as well as a reservoir for rapidly-reversible release of traces of it, to effect both direct (kd) and dissociative (kF) fluoride transfer.
Chem. Sci., 2024,15, 4331-4340
https://doi.org/10.1039/D3SC05776C
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Alternatives to fluorinated binders: recyclable copolyester/carbonate electrolytes for high-capacity solid composite cathodes
A series of poly(ester-b-carbonate) electrolytes are prepared by a one-pot procedure and structure–property relationships are observed. The polymer was used as a composite cathode binder with excellent discharge capacity and capacity retention.
Chem. Sci., 2024,15, 2371-2379
https://doi.org/10.1039/D3SC05105F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Infrared photoinduced electrochemiluminescence microscopy of single cells
Photo-induced electrochemiluminescence imaging of single cells is reported using an infrared light stimulus.
Chem. Sci., 2024,15, 2055-2061
https://doi.org/10.1039/D3SC05983A
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Deducing the conformational space for an octa-proline helix
The all-trans dyad can function as a molecular ruler but complications arise from the cis-configuration.
Chem. Sci., 2024,15, 1657-1671
https://doi.org/10.1039/D3SC05287G
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Rapid building block-economic synthesis of long, multi-O-GalNAcylated MUC5AC tandem repeat peptides
New methods allow the very smooth synthesis of highly pure MUC5AC glycopeptides containing 20 GalNAc units on 10 tandem repeats within a week.
Chem. Sci., 2024,15, 1297-1305
https://doi.org/10.1039/D3SC05006H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Insights into extended coupled polymethines through the investigation of dual UV-to-NIR acidochromic switches based on heptamethine–oxonol dyes
A series of heptamethine–oxonol dyes featuring different heterocyclic end groups were designed with the aim to explore structure–property relationships in π-extended coupled polymethines.
Chem. Sci., 2024,15, 1248-1259
https://doi.org/10.1039/D3SC06126D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Enhancing NIR-to-visible upconversion in a rigidly coupled tetracene dimer: approaching statistical limits for triplet–triplet annihilation using intramolecular multiexciton states
We report upconversion for a rigid tetracene dimer that yields 20× that of a monomer model. This is due to a 30× relative enhancement in TTA, indicating participation by intramolecular multiexciton states, including the 5TT, in productive channels.
Chem. Sci., 2024,15, 1283-1296
https://doi.org/10.1039/D3SC04795D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Keeping an “eye” on the experiment: computer vision for real-time monitoring and control
Chemists heavily rely on visual cues for routine tasks. Here, we introduce a computer vision system to automatically monitor and control diverse workup processes based on visual aspects, advancing toward autonomous operations.
Chem. Sci., 2024,15, 1271-1282
https://doi.org/10.1039/D3SC05491H
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Suppressing ACQ of molecular photosensitizers by distorting the conjugated-plane for enhanced tumor photodynamic therapy
This work demonstrates a novel strategy to address the notorious ACQ of non-AIE type fluorophores in an aqueous medium through deep insights into the structural effects leading to anti-ACQ properties, which could benefit the potential applications.
Chem. Sci., 2024,15, 940-952
https://doi.org/10.1039/D3SC05041F
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A 0D hybrid lead-free halide with near-unity photoluminescence quantum yield toward multifunctional optoelectronic applications
0D hybrid indium halide exhibits near-unity PLQY and negligible self-absorption realizing multiple cutting-edge optoelectronic applications in high-performance white LED, X-ray scintillation and reversible fluorescent probe toward tribromomethane.
Chem. Sci., 2024,15, 953-963
https://doi.org/10.1039/D3SC05245A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Fine-tuning GPT-3 for machine learning electronic and functional properties of organic molecules
Fine-tuned GPT-3 shows robust performance for the prediction of electronic and functional properties for organic molecules, with resilience to information loss and noise.
Chem. Sci., 2024,15, 500-510
https://doi.org/10.1039/D3SC04610A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Soluble Gd6Cu24 clusters: effective molecular electrocatalysts for water oxidation
Two synthesized Gd6Cu24 clusters—Gd6Cu24-IM and Gd6Cu24-AC—exhibit excellent electrocatalytic water oxidation activity in an aqueous solution of a weak acid (pH = 6) and had turnover frequencies of 319 and 169 s−1 at 1.70 V, respectively.
Chem. Sci., 2024,15, 511-515
https://doi.org/10.1039/D3SC05849B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Origin of dielectric polarization suppression in confined water from first principles
Atomistic simulations explain recent experimental findings of dielectric polarization suppression in confined water, revealing it originates in an anti-ferroelectric order driven by spontaneous antiparallel alignment of water dipoles at surfaces.
Chem. Sci., 2024,15, 516-527
https://doi.org/10.1039/D3SC04740G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Exploring the local solvation structure of redox molecules in a mixed solvent for increasing the Seebeck coefficient of thermocells
One-electron oxidation of a chloranil dianion (CA2−) to its radical form (CA˙−) disrupts the local solvation structure formed by ethanol in acetonitrile, resulting in a large entropy change and a large Seebeck coefficient of CA2−/˙− thermocells.
Chem. Sci., 2024,15, 146-153
https://doi.org/10.1039/D3SC04955H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Photoinduced cerium-catalyzed C–H acylation of unactivated alkanes
Ketones are ubiquitous motifs in the realm of pharmaceuticals and natural products.
Chem. Sci., 2024,15, 154-159
https://doi.org/10.1039/D3SC05162E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Photocatalytic, modular difunctionalization of alkenes enabled by ligand-to-metal charge transfer and radical ligand transfer
Simple iron salts are able to photocatalyze the diazidation, dichlorination, and fluorochlorination of alkenes via the merger of ligand-to-metal charge transfer (LMCT) and either radical ligand transfer (RLT) or fluorine atom transfer (FAT).
Chem. Sci., 2024,15, 124-133
https://doi.org/10.1039/D3SC05231A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
A single phosphorylation mechanism in early metabolism – the case of phosphoenolpyruvate
A nonenzymatic reaction converting pyruvate to phosphoenolpyruvate (PEP) is shown to proceed through carboxylate phosphorylation, suggesting that only a single phosphorylation mechanism was needed to initiate metabolic networks.
Chem. Sci., 2023,14, 14100-14108
https://doi.org/10.1039/D3SC04116F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Inserting an “atomic trap” for directional dopant migration in core/multi-shell quantum dots
Directional Mn dopant migration (outward/inward) was achieved by inserting a CdZnS “atomic trap” with a small size mismatch with dopants in core/multi-shell QDs. A larger initial substitutional site allows for active trapping and dopant migration.
Chem. Sci., 2023,14, 14115-14123
https://doi.org/10.1039/D3SC04165D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Crystallographic evidence for global aromaticity in the di-anion and tetra-anion of a cyclophane hydrocarbon
Anionic forms of a macrocyclic cyclophane were crystallized by treating the neutral hydrocarbon with alkali metals (Li, Na and K). The di-anions show decreased bond-length alternation, consistent with global aromaticity, whereas the anti-aromatic tetra-anion has a low-symmetry geometry.
Chem. Sci., 2023,14, 14109-14114
https://doi.org/10.1039/D3SC04251K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Synthesis of substituted benzylboronates by light promoted homologation of boronic acids with N-sulfonylhydrazones
The homologation of boronic acids with diazoalkanes obtained by photochemical decomposition of N-tosylhydrazones leads to substituted benzylboronates, previously unavailable under thermal conditions. Batch and continuous flow reactions are described.
Chem. Sci., 2023,14, 13765-13775
https://doi.org/10.1039/D3SC05678C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Intramolecular donor-stabilized tetra-coordinated germanium(IV) di-cations and their Lewis acidic properties
Intramolecular phosphine-stabilized tetra-coordinated Ge(IV) di-cations are established. Dispersed charges lead to Si–H activation initially at the P-site, which ultimately migrates to the Ge-site due to geometric constraint empowered Lewis acidity.
Chem. Sci., 2023,14, 13755-13764
https://doi.org/10.1039/D3SC03717G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Data science enabled discovery of a highly soluble 2,2′-bipyrimidine anolyte for application in a flow battery
Non-linear threshold analysis enabled discovery of a highly soluble (1.3 M) bipyrimidine anolyte. Stable cycling in a full flow battery cell for 75 cycles.
Chem. Sci., 2023,14, 13734-13742
https://doi.org/10.1039/D3SC04084D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Ligand-centered to metal-centered activation of a Rh(III) photosensitizer revealed by ab initio molecular dynamics simulations
Excited state evolution of the rhodium(III) complex [Rh(III)(phen)2(NH3)2]2+ (phen = 1,10-phenanthroline) has been investigated theoretically to gain a better understanding of light-driven activation of high-energy metal centered states.
Chem. Sci., 2023,14, 13713-13721
https://doi.org/10.1039/D3SC04381A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels
Substituted pyridazinediones (PDs) enable reversible and tuneable cysteine modification with exemplification on peptides, proteins and hydrogels.
Chem. Sci., 2023,14, 13743-13754
https://doi.org/10.1039/D3SC04976K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Controlling primary chain dispersity in network polymers: elucidating the effect of dispersity on degradation
The development of a one-pot method to tune the primary chain dispersity in polymer networks and the notable effect of primary chain dispersity on gel degradation.
Chem. Sci., 2023,14, 13419-13428
https://doi.org/10.1039/D3SC05203F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Unprecedented sesterterpenoids, orientanoids A–C: discovery, bioinspired total synthesis and antitumor immunity
We report a holistic study of the isolation, structure elucidation, total syntheses, and biological evaluation of three unprecedented sesterterpenoids, orientanoids A–C (1–3).
Chem. Sci., 2023,14, 13410-13418
https://doi.org/10.1039/D3SC04238C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Regioselective ortho halogenation of N-aryl amides and ureas via oxidative halodeboronation: harnessing boron reactivity for efficient C–halogen bond installation
We report the discovery of an ortho regioselective oxidative halodeboronation of N-aryl amides and ureas with wide-ranging applications in pharmaceuticals, materials science, and synthetic organic chemistry.
Chem. Sci., 2023,14, 13429-13436
https://doi.org/10.1039/D3SC04628A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Net-clipping as a top-down approach for the prediction of topologies of MOFs built from reduced-symmetry linkers
Net-clipping is a strategy for the topological prediction of MOFs built with reduced-symmetry linkers. It is based on the deconstruction of nets by clipping half of the connectivity in tetrahedral, hexagonal, cubic or hexagonal prismatic nodes.
Chem. Sci., 2023,14, 12984-12994
https://doi.org/10.1039/D3SC04406H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
A role of intermolecular interaction modulating thermal diffusivity in organosuperelastic and organoferroelastic cocrystals
Anisotropic thermal diffusivity correlates with the intermolecular interactions in two cocrystals with varying halogen acceptor abilities, which also influenced the superelastic and ferroelastic behaviour.
Chem. Sci., 2023,14, 12995-13006
https://doi.org/10.1039/D3SC03155A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Melamine-cored glucosides for membrane protein solubilization and stabilization: importance of water-mediated intermolecular hydrogen bonding in detergent performance
A melamine-based glucoside, MG-C11, has the ability to form a dynamic hydrogen-bonding network between detergent molecules, responsible for the markedly enhanced efficacy for GPCR stabilization compared to LMNG and previously developed TTG-C11.
Chem. Sci., 2023,14, 13014-13024
https://doi.org/10.1039/D3SC03543C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Expanding the chemical space of enol silyl ethers: catalytic dicarbofunctionalization enabled by iron catalysis
Herein, we report the dicarbofunctionalization of enol silyl ethers via an Fe-catalyzed decoupled cross-coupling of (fluoro)alkyl halides, and enol silyl ethers.
Chem. Sci., 2023,14, 13007-13013
https://doi.org/10.1039/D3SC04549H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Identification of non-conventional small molecule degraders and stabilizers of squalene synthase
Small molecule degraders and stabilizers of squalene synthase based on the same scaffold are reported, which respectively accelerate or block its natural degradation.
Chem. Sci., 2023,14, 12973-12983
https://doi.org/10.1039/D3SC04064J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Stretchable, recyclable thermosets via photopolymerization and 3D printing of hemiacetal ester-based resins
We develop a platform for recyclable polyurethane-based thermosets fabricated by photopolymerization. Tunable mechanical properties and 3D printing are demonstrated, with mild acid-catalyzed degradation enabled by hemiacetal linkages.
Chem. Sci., 2023,14, 12535-12540
https://doi.org/10.1039/D3SC03623E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Systematic exploration of accessible topologies of cage molecules via minimalistic models
Minimal models of cages are used to map the accessible cage topologies based on building block properties.
Chem. Sci., 2023,14, 12506-12517
https://doi.org/10.1039/D3SC03991A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
New insights into controlling radical migration pathways in heme enzymes gained from the study of a dye-decolorising peroxidase
We show that radical migration in a heme peroxidase can be controlled and directed to a rationally designed site through simply removing an oxygen atom form the protein structure.
Chem. Sci., 2023,14, 12518-12534
https://doi.org/10.1039/D3SC04453J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Realizing long range π-conjugation in phenanthrene and phenanthrene-based molecular crystals for anomalous piezoluminescence
A long range π-conjugation has been realized by the designed π–π interactions in phenanthrene/phenanthrene-based molecular crystals, forming the “transannular effect”, which can be amplified by high pressure and induce novel piezoluminescence.
Chem. Sci., 2023,14, 11629-11637
https://doi.org/10.1039/D3SC04006B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
A cellular platform for production of C4 monomers
In this work, we describe the engineering of a microbial platform to produce six different C4 chemicals at near quantitative yields using a combination of metabolic engineering and directed evolution.
Chem. Sci., 2023,14, 11718-11726
https://doi.org/10.1039/D3SC02773B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Metal organic layers enabled cell surface engineering coupling biomembrane fusion for dynamic membrane proteome profiling
A novel method termed cell surface engineering coupling biomembrane fusion based on metal organic layers was developed for dynamic membrane proteome profiling.
Chem. Sci., 2023,14, 11727-11736
https://doi.org/10.1039/D3SC03725H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Broadening the catalytic region from the cavity to windows by M6L12 nanospheres in cyclizations
M6L12 nanospheres, with isolated gold sites fixed on the windows, were utilized as an example to prove that the cage windows present a confinement effect for substrate pre-organization and transition state stabilization leading to high rates.
Chem. Sci., 2023,14, 11699-11707
https://doi.org/10.1039/D3SC02998K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Structural distortion by alkali metal cations modulates the redox and electronic properties of Ce3+ imidophosphorane complexes
Structural distortion of the secondary coordination sphere driven by the incorporation of an alkali metal in Ce3+ imidophosphorane complexes tunes the Ce3+/4+ oxidation potential.
Chem. Sci., 2023,14, 11708-11717
https://doi.org/10.1039/D3SC04262F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Acyl-caged rhodamines: photo-controlled and self-calibrated generation of acetyl radicals for neural function recovery in early AD mice
A general design strategy for photo-triggered release of acyl radicals was developed. With an acetyl radical donor, we showed the potential of acyl radicals to precisely modulate cell redox homeostasis, to promote NSC differentiation, and to improve the cognitive abilities of early AD mice.
Chem. Sci., 2023,14, 11689-11698
https://doi.org/10.1039/D3SC03035K
About this collection
This on-going web collection showcases all of the HOT Chemical Science articles published in 2023, as recommended by referees. Congratulations to all of the authors whose articles are featured.