Themed collection 2021 Focus and Perspective articles

This perspective describes the applications of Passerini reactions in the last two decades from 2000 to 2021 in pharmaceutical applications and synthesis of peptides, natural products, macrocycles, dendrimers, and versatile types of heterocycles.

The present article summarizes the various tools developed in the context of the SILCS methodology and their utility in computer-aided drug design (CADD) applications.

This overview provides comprehensive understanding and development trends of hierarchical Bi₂MoO₆ nanostructures as photocatalysts for efficient photocatalysis applications.

The use of neutral donor ligands is an effective strategy to modify catalyst structure and performance in the synthesis of sustainable polymers through the ring-opening polymerization (ROP) of cyclic esters.

Ionic liquids (ILs) have received continuous attention owing to their unique chemical and physical properties and to their successful integration in several applications.

This perspective describes the journey of C–S bond constructions starting from transition metal catalysis through oxidant catalysis, photocatalysis and very recently employed electrocatalysis by using various sulfur surrogates.

This perspective describes the use of pyrochlore oxides in photocatalysis with focus on the strategies to enhance their activity.

This article discusses recent progress in the development of Fe-derived noble metal-free electrocatalysts, including the strategies used for design, synthesis, and assessment of their performance in alkaline conditions.

The present review covers all synthetic methods based on isocyanide-based multicomponent reactions for the preparation of polysubstituted pyrroles as the parent cores of many essential drugs, biologically active compounds, and compounds with wide application in materials science.

This review focuses on the process of preparation of nanofibers via Es, the design and setup of the instrument, critical parameter optimization, preferable polymers, solvents, characterization techniques, and recent development and biomedical applications of nanofibers.

Fabrication of multilayer EMI shield opens a creative avenue for designing and constructing flexible nanocomposite films simultaneously featuring excellent EMI shielding performance, fascinating heat removal ability, and robust mechanical properties.

Organosulfur, organoselenium, and organotellurium ligands in designing Pd, Ni, and Cu-based homogeneous, heterogeneous, and nanocatalytic systems for Heck coupling.

In the present review, the types and activities of nanometer-sized enzymes are summarized, with recent progress of nanometer-sized enzymes in the field of biomedical detection.

Recent progress and future directions in the creation of hybrid structures based on 2D polymers and inorganic 2D materials are discussed.

The latest methods for the preparation/functionalization of azapyrenes, and their photophysical/electrochemical properties and possible applications are overviewed.

This review highlights (2010–2021) different strategies for the construction of the phthalimide core apart from traditional synthetic routes.

The preparation of heterocyclic compounds has attracted great attention in organic chemistry because of their extensive application in the field of bioactive molecules, materials science, and natural products.

The design and synthesis of suitable chemodosimeters for the detection of toxic analytes has become challenging for new researchers nowadays in the molecular recognition field.

In the past decade, the synthesis of sugar-based ionic liquids (SILs) from natural sugars has been described as a promising strategy.

Chalcogenides and chalcogenide-based heterostructures as photocatalysts.

Tuneable properties of conjugated polymers are attractive for use in multiple domains like optical, electronic and biological applications.

Many researchers claim that graphene, a specially studied carbon allotrope, has a single layer of atoms organized in a two-dimensional honeycomb lattice.

A gradual shift from metal-catalyzed to metal-free methods is occurring, as the latter are more environmentally benign. This review discusses sustainable protocols for the construction of C–C, C–N, C–P, C–S, and C–O bonds via C–H functionalization of quinoxalin-2(1H)-ones.

A comprehensive electrosulfonylation study has been carried out via cathodic and anodic approaches for the production of organosulfone and sulfonamide derivatives.

The MOFs derived catalysts conducted in the chemoselective hydrogenation of substituted nitroarenes, including pyrolysis and confined catalyst, are reviewed.

This review describes methods for the synthesis of o-tolyl benzonitrile, such as Pd-, Ni-catalyzed Suzuki, Negishi and Kumada couplings reactions.

Reduced detection temperature of hazardous gases such as H₂S can lower power consumption and increase the long-term stability. The decreased operating temperature can be achieved via physical and chemical modification of the sensing layer.

The copper-catalyzed N-arylation of pyrroles has attracted great attention in organic synthesis due to its wide applications in medicinal chemistry, natural products, etc. Here, we summarize the overall advances in the copper-catalyzed C–N cross-coupling of pyrroles with aryl halides.

In recent years, Dakin oxidation has evolved primarily around the conversion of ortho- and para-hydroxy benzaldehydes and acetophenones to dihydric phenols, which are found in nature and complex organic materials.

Molecular iodine contributes significantly to organic transformations in synthetic organic chemistry. It works effectively due to its mild Lewis acidic character, ability as an oxidizing agent, good moisture stability, and easy availability.

–SO₃H functionalized silica and alumina have emerged as efficient and eco-compatible heterogeneous solid acid catalysts for the construction of various important molecular skeletons.

This review highlights the medical applications of multi-stimuli-responsive hydrogels as self-healing hydrogels, antibacterial materials and drug-delivery systems.

Transition metal catalysed C–H activations are efficient, simple, mild, cost-effective and stereoselective, and many of them are environmentally sustainable transformations.

The latest progress in the assembly of porphyrin derivatives on solid surfaces.

Fluorescence is widely used to detect functional groups and ions, and peptides are used in various fields due to their excellent biological activity.

Multifunctional interfacial materials with special wettability including superhydrophobic, superamphiphobic, and SLIPS exhibited promising potentials for corrosion and biofouling resistance.

This review focuses on interactions which govern release from plasmonic carrier systems including liposomes, polymersomes, and nanodroplets under pulsed irradiation.

Recent progress in electrochemical aptasensors for the detection of HCC-related biomarkers, including cancer cells, proteins, cell-derived exosomes, and nucleic acids, is reviewed.

This review summarizes the recent progress in zwitterionic materials through the concepts of interfacial dipoles and passivating defects.

Modular, well-defined, and robust hierarchical functional materials are targets of numerous synthesis endeavors.

We summarized the Ir-catalysed borylation of PAHs, especially pyrene, and the optoelectronic materials generated by following this chemistry. The optoelectronic properties of pyrene derivatives have also been discussed.

Nanotechnology is an emerging science involving the manipulation of matter on the nanometer scale.

A recent review on the α-C–H functionalization of tertiary amines using low-cost and benign I₂ or its derivatives.

This review presents the diverse synthesis of 3,4-substituted coumarins and 5-, 6- and 7-membered ring fused coumarins using 4-chloro-3-formylcoumarin as the precursor via classical reactions including metal-catalyzed and green reaction protocols.

Nanoprobes based on various nanomaterials, polymers or AIEgens are overcoming previous limitations for diagnosis and therapy of early-stage protein aggregation.

Xanthenes are a class of natural and synthetic heterocyclic compounds that exhibit a broad spectrum of biological properties and synthetic applications.

This review summarises a wide range of transformations on the indole skeleton, including arylation, alkenylation, alkynylation, acylation, nitration, borylation, and amidation, using transition-metal catalyzed C–H functionalization as the key step.

We have considered the newest outcomes in the uses of 3D-printed COF- and MOF-based materials for diverse applications.

This review summarizes the recent developments in the synthesis of a variety of substituted quinoxalines using transition metal catalysts.

Core-functionalized nanoaggregates can be prepared by a combination of polymerization-induced self-assembly (PISA) and post-polymerization modification.

This review describes the evolution and application of active metal-based and heterometallic NPs as efficient heterogeneous catalysts for the synthesis of pyridine derivatives by multicomponent reactions in the last decade (2010–2020).

This perspective provides a comprehensive overview of the latest progress of M–CN, which would promote further development, such as for single-atom catalysis and nanozymatic reactions.

The 1,3-dipolar cycloaddition reaction of nitrone is one of the most important methods for the synthesis of different sizes of heterocycles which have enormous applications in natural products, biologically active molecules and pharmaceuticals.

This study summarizes the stereochemical outcomes of [3+2] cycloaddition of allene molecules with 1,3-dipolar carbonyl ylides derived from Rh(II) carbene-mediated diazo decomposition for the formation of highly diastereoselective poly oxacarbocycles.

In this article, the structural characteristics and synthetic methods of copper iodide hybrid materials are introduced, and the strategies for optimizing the stability and luminescence properties of these compounds are reviewed.

Molecules that experience a change in their fluorescence emission due to the effect of fluorescence enhancement upon binding events, like chemical reactions or a change in their immediate environment, are regarded as fluorescent probes.

Recent progress on advanced transition metal catalysts for propylene polymerization and copolymerization are reviewed.

Chitosan and its hybrids, as an appropriate bioink in 3D printing technology, for the fabrication of engineered constructions.

The evergrowing demand for cleaner, high-performing energetic materials (EMs) has led to a quest for replacement of currently used toxic metal-based traditional energetic compounds such as lead azide and lead styphnate.

Recent advancements in versatile synthetic transformations using quinone diazide based metal carbenes have been summarized.

This review highlights the synthetic aspects, structural diversity and possible applications of organozinc hydrazides and their derivatives.

This review aims to cover the simultaneous method of using molecularly imprinted technology and quantum dots (QDs) as well as its application in the field of optical sensors.

MXenes, since their discovery in 2011, have garnered significant research attention for a variety of applications due to their exciting physico-chemical properties.

The recent advances in radical reactions for the direct functionalization of imidazo[1,2-a]pyridines are reviewed.

Azomethine imines constitute a versatile class of 1,3-dipoles which was used extensively for biologically relevant N-heterocycle synthesis – a five-year recap.

We have considered the newest momentous outcomes in carbon-based nanomaterials for utility in controlling and fighting the SARS-CoV-2 virus.

A comprehensive review of chromo-fluorogenic sensors developed using vitamin B₆ cofactors as the analyte recognition unit.

Bio–nanocomposite compounds based on biopolymers and MOFs have presented great potential in various applications for modern technology.

Organic nitrogen–chlorine compounds and their derivatives are important heterocyclic motifs, exhibiting applications such as N-chlorinating agents, analytical reagents, disinfectants, antipathogens, and as synthetic intermediates for drugs, polymers, and natural products.

The main three methods of interface design for carbon/polymer composites for different carbon materials.