Aquaporins in cancer development: opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents
Metal ions and complexes can interfere with the transcellular water flow but also with the cellular transport of glycerol and hydrogen peroxide, via inhibition of the ubiquitous aquaporin channels.
Exploiting developments in nanotechnology for the preferential delivery of platinum-based anti-cancer agents to tumours: targeting some of the hallmarks of cancer
A comprehensive overview showcasing how liposomes, nanocapsules, polymers, dendrimers, nanoparticles and nanotubes may be employed as vehicles to selectively deliver cytotoxic platinum drug payloads to tumour cells.
Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS
Two isosteric organometallic drug candidates revealed distinct in vivo antitumour activities and spatial distributions in mouse tissues.
Paper
Metallomic study on the metabolism of RAPTA-C and cisplatin in cell culture medium and its impact on cell accumulation
The different extracellular speciation of cisplatin and the organoruthenium developmental anticancer agent RAPTA-C impacts the accumulation in cancer cells.
Gold(I) phosphine compounds as parasite attenuating agents for malaria vaccine and drug development
The asexual blood-stage Plasmodium parasite attenuating properties of gold(I) phosphine compounds are exploited in a novel strategy for malaria vaccine development.
On the toxicity and transport mechanisms of cisplatin in kidney tissues in comparison to a gold-based cytotoxic agent
The toxic effects and accumulation mechanisms of cisplatin in healthy rat kidneys has been studied ex vivo, using the Precision Cut Tissue Slices (PCTS) method, in comparison to those exerted by an experimental cytotoxic Au(III) compound.
Paper
Comparative studies of oxaliplatin-based platinum(IV) complexes in different in vitro and in vivo tumor models
New perspectives for the development of platinum(IV) prodrugs of the anticancer agent oxaliplatin, combining bioreductive properties and immunogenic aspects, are shown.
Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans
Select metal-binding agents form strong, lipophilic complexes with copper(II) that alter the cellular metal status of the opportunistic fungal pathogen Cryptococcus neoformans and demonstrate copper-dependent antifungal activity.
MicroXRF tomographic visualization of zinc and iron in the zebrafish embryo at the onset of the hatching period
Synchrotron-based X-ray fluorescence microtomography offers new insights into the three-dimensional distribution of zinc and iron at a key stage of zebrafish embryogenesis.
Comparison of KP1019 and NAMI-A in tumour-mimetic environments
Biotransformations of Ru(III) anticancer drugs are compared under a range of controlled hypoxia levels provided by spheroids at different sizes.
Paper
Cellular uptake of metallated cobalamins
Cellular uptake of vitamin B12-cisplatin conjugates was estimated via detection of their metal constituents (Co, Pt, and Re) by inductively coupled plasma mass spectrometry (ICP-MS).
The S2 Cu(I) site in CupA from Streptococcus pneumoniae is required for cellular copper resistance
We report the solution structure of apo-CupA and establish the functional primacy of the S2 Cu(I) in cellular copper resistance.
About this collection
This collections features recent articles in Metallomics by speakers and discussion leaders at the 2018 Metals in Medicine Gordon Research Conference. This conference covers a cross-cutting field that incorporates scientific advances in inorganic chemistry, cell and molecular biology, advanced spectroscopy and biophysics, nuclear medicine, medicinal chemistry, clinical medicine, and other disciplines in ways that leverage knowledge of metals to prevent, diagnose, and treat human disease. It is being held from the 24-29th June 2018 at Proctor Academy, New Hampshire, USA. The 2018 conference chairs are Seth M. Cohen and Kenneth Kam-Wing Lo.