Themed collection Biomaterials Science Recent HOT Articles

Wired electrodes for nervous system stimulation have inherent limitations. Electrostimulation using unwired bipolar electrodes offers a new paradigm to drive growth and repair of nervous tissue.  It also opens a wide field for innovation of electrode materials and protocols.

Extracellular vesicles (EVs) are vesicles with lipid bilayer structures shed from the plasma membrane of cells.

The emerging role of T cells, stromal cells, and senescent cells and their interactions with other cell types in the FBR are discussed in this review. Additionally, factors that modulate the phenotype of these cells are briefly considered.

The CRISPR/Cas9 systems contain three modes: I. plasmid DNA encoding both Cas9 and sgRNA; II. Cas9 mRNA and sgRNA; III. Cas9 protein and sgRNA. We summarized the application of the synthesized nanomaterials for delivery the CRISPR/Cas9 systems.

Development of a novel biomaterial-based CRISPR-Cas9 system for the precise control of genome editing.

Nanomedicine recognition and clearance by the mononuclear phagocyte system (MPS) impedes optimal clinical impacts for this class of materials. We present an overview of factors involved in MPS interactions and approaches to overcome this barrier.

The study develops a computational framework to model factors that lead to the evolution of autoreactive T cells in inflammatory arthritis. The results provide a tool for planning immunomodulatory strategies focused on new disease-modifying agents.

Immediate care of skin wounds and burns is essential to repair this mechanical and chemical barrier to infections.

The supercritical (SC) fluid-based method were utilized for nerve tissue decellualrization. In vitro, vivo assessments underscore its potential for advanced tissue engineering and regenerative applications.

This article demonstrates an inverse emulsion scheme to polymerize a variety of ionizable and non-ionizable monomers to form stimuli-responsive nanoparticles with potential applications in biomaterials science.

In the present study, we report the first synthesis of diazirine-modified hyaluronic acid (HA–DAZ).

The AIE photosensitiser TPE-EPy@CB[7] was prepared by supramolecular self-assembly, which effectively enhanced the type-I ROS generation capacity. MNs facilitated precise drug delivery and enhanced light penetration into deeper layers of the tumor.

Development of a light-responsive face mask with enhanced filtration properties and on-demand photodynamic and photothermal-driven pathogen eradication.

The human placenta is a complex organ comprised of multiple trophoblast subtypes, and inadequate models to study the human placenta in vitro limit the current understanding of human placental behavior and development.

The use of egg microneedles (EMN) is a promising transdermal vaccine delivery technique, effectively preserving the vaccine's activity during its dissolution and delivery directly into the skin upon administration.

PLGA NPs can serve as an excellent nanoplatform, and GEF@PLGA NPs exhibit tumor-specific responses and high antitumor properties, which may facilitate the use of less toxic GEF in prostate cancer treatment regimens.

Alcohol solvents are encapsulated in palm oil-based microcapsules for the effective transdermal delivery of high-content actives.

Surface coating with dopamine conjugated hyaluronic acid (HA–DP) can interact with lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) to preserve the phenotypes and functionality of lymphatic endothelial cells (LECs).

Despite exquisite immune response modulation, the extensive application of microRNA therapy in treating heart transplant rejection is still impeded by poor stability and low target efficiency.

The controlled release of antigens from zwitterionic-modified polysaccharide hydrogel microparticles has been actively pursued to achieve long-lasting immune responses in vaccine development.

The mutual interaction between reactive species generated by non-thermal plasma and biopolymers in solution causes oxidative modifications that can have an impact in biomedical applications.

Globular folded proteins are powerful building blocks to create biomaterials with mechanical robustness and inherent biological functionality.

Bioadhesive hydrogel patches based on chemically modified photocrosslinkable polymers with specific physicochemical properties for sealing and repair of ocular injuries.

A smart skin regeneration platform that can enhance their selective cellular uptake to fibroblasts via PAR-2 receptor mediated endocytosis is proposed.

GSH depleting prodrugs and ROS generators self-assemble to generate oxidative stress nanoamplifiers that can preferentially kill cancer cells and exert immunostimulating activity.

The proposed photoclick HC–HN bioink expands the palette of available polysaccharide-based bioinks and greatly extends the biofabrication window to broaden the application opportunities of 3D bioprinting.

An injectable adhesive hydrogel based on N-hydroxysuccinimide γ-poly(glutamic acid) and 4-armed poly(ethylene glycol) amine showed rapid gelation time, strong mechanical strength, satisfactory burst pressure and excellent hemostatic performance.

Flash nanotechnology-produced nanomedicines exhibit potent antioxidant and anti-inflammatory properties and could overcome mucosal barrier for oral delivery, resulting in great efficiency in the prevention and treatment of colitis-associated colorectal cancer.

A component-optimized chemo-dynamic nanoagent achieved an enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model.

Biodegradable peptide polymers display potent and broad-spectrum antibacterial activity in vitro, as well as strong therapeutic potential in vivo, as a promising alternative to antibiotics in aquaculture.

A multifunctional nanoplatform has been developed based on boron nanosheets loaded quaternized chitosan and NO donor N,N′-di-sec-butyl-N,N′-dinitroso-1,4-phenylenediamine for rapid, and effective treatment of pathogenic bacteria.

Plant-inspired gallol-containing surfactants have been successfully incorporated into typical Pluronic® micelles, allowing low critical micelle concentration, great colloidal stability, and exterior enzyme resistance.

Lymph node-inspired 3D hydrogels with precisely defined porosity were produced, which improve the state-of-the-art T cell proliferation, a procedure that is especially important for novel cellular immunotherapies.

The polymer dual drug conjugate synthesized by coupling docetaxel (DTX) and docosahexaenoic acid (DHA) with bifunctionalized dextran is selectively accumulated in tumor and nearly eradicates all MCF-7 tumors bearing in nude mice.

Fatty acid-tethered polymers were synthesized via RAFT method to explore their potential role in preventing insulin aggregation process. The results endowed fatty acid-tethered polymers with properties to act as novel anti-amyloidogenic agents.

Polycaprolactone/silica hybrids offer a dual therapeutic effect: the promotion of bone regeneration thanks to silicate ions and strong antibacterial properties against the risk of osteomyelitis.

By developing DPA-TPE-DCM with intense near-infrared fluorescence emission in the aggregation state, AIE materials were used for the first time in the early diagnosis of orthotopic TSCC and SLN mapping in an orthotopic TSCC-bearing mouse model.

Amphiphilic cationic anticancer lipopeptide P10 self-assembles into spherical aggregates, which are used as drug carriers to play a synergistic anticancer role, and its anticancer mechanism is presented.

A bionic biphasic composite scaffold with on-demand osteochondrogenic factors facilitated the regeneration of osteochondral defects.

The local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration via synergistic immunomodulation of osteogenesis and osteoclastogenesis by macrophages.

In this work, capillary tubes with different diameters were chosen to mimic a confined environment and the effect of space on the self-assembly behavior of short peptides with different oil-water partition coefficients (log P) was investigated.

We have designed a dual-function microneedle patch that integrates treatment and diagnosis.

Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance.

A kind of blood-repellent mist spray (MS) was proposed to prevent blood adhesion during surgery and played an important role in antibacterial and wound-healing, which could be widely used in the surface modification of various medical gloves.