Themed collection Analyst Review Articles 2023

This review aims to introduce the development of DNA nanotechnology and recent advances of DNA nanostructure-based delivery systems for bioimaging, disease diagnosis, and therapeutic applications.

Surface-enhanced Raman scattering (SERS) is a very important tool in vibrational spectroscopy.

The small-molecule fluorescent probes for bioactive species in inflammatory disease, mainly in arthritis, pneumonia and hepatitis are systematically summarized.

This feature article summarizes current immunological assay methods for the detection of infectious diseases, highlighting the trend of future development.

An overview of the principles and applications of GFP-based biosensors.

Paper-based microfluidics offers a promising way to in situ sweat detection for non-invasive continuous monitoring. This passage reviews and prospects its development regarding materials, structuring, fabrication, modular design and application.

In this minireview, we have provided a summary of the recent advancements in optical chemodosimeters for ozone detection from 2009 to 2022.

This review outlines the fabrication and function of MXene-based E-skins. Starting with the synthesis of pure MXenes, then walking through the steps of designing sensors, integrating electronic skin arrays and determining the various functions.

This review described current methods for the detection of viable Escherichia coli, including culture-based methods, molecular approaches targeting DNA and RNA, bacteriophage-based methods, biosensors, and other emerging strategies.

The abnormal expression of human DNA methyltransferases (DNMTs) is closely related with the occurrence and development of a wide range of human cancers.

This review focuses on synthesis methods for N, B, P, and S co-doped graphenes and graphene-based composites and comprehensively discusses their recent applications in the fields of sensors, adsorbents and catalysis.

Metal ions are indispensable elements in living organisms and are associated with regulating various biological processes.

This review comprehensively discusses the methods and applications of various microfluidic functionalities for implantable medical devices.

With the development of new technologies for rapid and high-throughput bacterial detection, ATP-based bioluminescence technology is making progress.

A conventional molecular assay-based point-of-care (POC) diagnostic test involves three major stages: deoxyribonucleic acid (DNA) extraction, amplification, and amplicon detection.

Molecular interactions at interfaces have a significant effect on the wetting properties of surfaces on a macroscale.

The creation of reagentless protein-based biosensors that are capable of monitoring molecular analytes directly in bodily fluids could revolutionize our understanding of biology and personalized health monitoring.

Cosmetics can beautify the skin and assist the treatment of skin diseases. Some methods have been developed to replace animal experiments for cosmetic screening. The microfluidic skin chip is considered as a effective tool for in vitro tests.

Nucleic acid testing for HIV plays an important role in the early diagnosis and monitoring of antiretroviral therapy outcomes in HIV patients and HIV-infected infants.

The research progress and applications of colorimetric sensors based on nanozymes with peroxidase-like activity.

This review provides a broad overview of mass spectrometry-based proteomics and highlights four developing areas: (1) protein inference, (2) alternative proteases, (3) sample-specific databases and (4) post-translational modification discovery.

Cortisol sensing using molecular sensors, aptamers and antibodies was explored, focusing on important analytical parameters.

Synthesis, characterization, and application of carbon dots@noble metal nanocomposites.

With the increase in people's living standards, the number of patients suffering from liver injury keeps on increasing.

Scaled-up production of nano-formulations is challenging. Find out how microfluidic manufacturing simultaneously meets the requirements for quality and throughput.

Fluorometric, colorimetry, chemiluminescence, SERS, and dual-mode techniques for biosensing and imaging of telomerase are summerized. Relevant signal amplification strategies are included to provide ideas for exploration of more practicable methods.

Fluorescent nanoparticle (FNP)-based dual-emission ratiometric fluorescent probes (DRFP) are summarized as hybrid FNPs, single FNPs with intrinsic dual emission and target-induced new emission, and DRFPs based on auxiliary nanomaterials.

Seeing is believing - and optical sensors (optodes) are ideal tools to make chemistry visible in real time. Find out how technological and chemical advances enable multiparameter imaging of complex samples.

Surface-enhanced Raman spectroscopy has become a promising analytical method for raw material identification, bioactive component detection, adulterant characterization, and contaminant detection of Chinese herbal medicines.

Mass spectrometry imaging (MSI) has advanced from a niche technique to a widely applied spatial biology tool. This review highlights state-of-the-art MSI application in emerging and the six largest biomedical fields according to a set of criteria.

Recently, surface plasmon resonance (SPR) biosensors have been widely used in environmental monitoring, food contamination detection and diagnosing medical conditions due to their superior sensitivity, label-free detection and rapid analysis speed.

Plasmonic nanoparticles etching based label-free multicolorimetric sensors for biosensing and chemosensing applications

Ensuring food safety is a critical concern for the development and well-being of humanity, as foodborne illnesses caused by foodborne bacteria have increasingly become a major public health concern worldwide.

The breast tumor microenvironment, preclinical breast cancer models, fabrication methods, breast tumor-on-chip models, and applications are summarized.

Solvent free strategies for greener fingermark development.

This review focuses on aptasensors for K⁺ detection, their signal generation strategies, their analytical performance, factors that affect their efficiency with major challenges and future prospects.

Food additives have become a critical component in the food industry.

Deformation-assisted microfluidic cell sorting technologies according to how the deformability is characterized and the form in which the force acts.

In this review, we summarize the recent advances in quantitative technologies for the analysis of cancer-related exosome proteins according to probe and sensing strategies and discuss the challenges and prospects of exosome protein detection methods.

The significant development of bioparameter-directed nanoformulations as MRI contrast agents for tumour diagnosis has been explained.

This review outlines the overview, advances and opportunities of genetically encoded fluorescence lifetime biosensors, including their combination of lifetime imaging technique and lifetime analysis methods, applications and future consideration.

This review focus on highlights the recent advances in wearable sensor toward continues and monitoring the risk factors of metabolic syndrome (MS).

Possessing the attractive advantages of moderate invasiveness and high compliance, there is no doubt that microneedles (MNs) have been a gradually rising star in the field of medicine.

This review explores lateral flow assays for pathogenic viruses and bacteria, with a particular focus on methodologies, device components, construction methods, and applications.

Review of the ability of high resolution mass spectrometry to detect, type, subtype and distinguish variants and sub-variants in virus clinical specimens with high confidence.

The present review presents the advances in ratiometric pH probes development for ΔpHi mapping in cellular organelles. Furthermore, we highlight the major challenges in developing ratiometric probes that merit further research in the future.

Environmental protection and food safety are closely related to the healthy development of human society; there is an urgent need for relevant analytical methods to determine environmental pollutants and harmful substances in food.

Commercial assay kits for H₂S and NO have already been achieved, whereas the development of assay kits for CO remains challenging. This review scrutinizes the advancement, limitations, and prospects of CO molecular probes.

A schematic diagram of the main methods for hepatitis B detection.

The cell is the most basic structural unit and plays a vital role in the function of an organism.

Carbonyl compounds relevant for the indoor environment are presented and analytical methods for determining their indoor air concentrations are discussed.

In recent years, magnetic nanoparticle sensor technologies have attracted considerable interest in the point-of-care-testing (POCT) field, especially in lateral flow immunoassays (LFIAs).

More environment-friendly solvents in analytical chemistry are almost inevitable in both sample preparation and analysis to meet the high standards of sustainable chemistry and human welfare.

The advances in 3D capillary-driven microfluidics for bioanalytical devices, including design and surface chemistry, are presented. Classification of capillary flow control elements is presented based on two functional steps of stop and actuation.

This review summarizes recent advances on metal-organic frameworks for the applications in photoelectrochemical and electrochemiluminescence biosensors.

This review focuses on the theoretical concepts, electrode engineering, data analytics, and biomedical applications of electric and electrochemical microfluidic platforms, and highlights future directions for development.

Development of photoelectrochemical sensors interfaced with semiconductor quantum dots (QDs) as a promising approach for fabricating new photoelectrodes and photoelectrochemistry systems suitable for energy storage and biosensing applications.

Homogeneous immunosensors integrate the advantages of both biosensors and immunoassays; they include speed, high sensitivity, and accuracy.

Typical forms of a combination of electrowetting-on-dielectric (EWOD) technology with sensing and other microfluidic manipulation techniques are reviewed from a technical perspective, including the purposes, significance, and biomedical applications.

Proteins are major drug targets, and drug–target interaction identification and analysis are important factors for drug discovery. The properties of protein-drug interaction can be evaluated using AFM-based approaches.

We present a comprehensive review on droplet microfluidics for CTC-based liquid biopsy.

In this review, we summarise the device design strategies and the recent development in single-cell ECL analysis systems (sensing and imaging systems), as well as the modification of ECL probes through different functionalization strategies.