Synthetic ramoplanin analogues are accessible by effective incorporation of arylglycines in solid-phase peptide synthesis

Edward Marschall, Rachel W. Cass, Komal M. Prasad, James D. Swarbrick, Alasdair I. McKay, Jennifer A. E. Payne, Max J. Cryle and Julien Tailhades

Chem. Sci., 2024, 15, 195
DOI: 10.1039/D3SC01944F

Recent advances in discovery and biosynthesis of natural products from myxobacteria: an overview from 2017 to 2023

Chao-Yi Wang, Jia-Qi Hu, De-Gao Wang, Yue-Zhong Li and Changsheng Wu

Nat. Prod. Rep., 2024, 41, 905
DOI: 10.1039/D3NP00062A

Structures, biosynthetic pathways, and biological significance of bacterial aryl-heterocycle metallophores with emphasis on yersiniabactin-type derivatives

Martinus de Kruijff, Sebastian Götze and Christine Beemelmanns

Nat. Prod. Rep., 2025, 42, 2075
DOI: 10.1039/D5NP00045A

Lipid-donor-anchored genome mining uncovers dioxanopeptins, antibacterial lipopeptides with a 1,3-dioxane functionalized polyunsaturated lipid tail

Ying Chen, Yunsheng Chen, Hao Xiang, Changqi Luo, Jiaqi Duan, Kun Hu, Xiaohong Zheng, Jing Liu, Yongbo Xue and Yi-Ming Shi

Chem. Sci., 2026
DOI: 10.1039/D6SC00003G

Marine natural products

Anthony R. Carroll, Brent R. Copp, Tanja Grkovic, Robert A. Keyzers and Michèle R. Prinsep

Nat. Prod. Rep., 2025, 42, 257
DOI: 10.1039/D4NP00067F

Cyclic natural product oligomers: diversity and (bio)synthesis of macrocycles

Songya Zhang, Shuai Fan, Haocheng He, Jing Zhu, Lauren Murray, Gong Liang, Shi Ran, Yi Zhun Zhu, Max J. Cryle, Hai-Yan He and Youming Zhang

Chem. Soc. Rev., 2025, 54, 396
DOI: 10.1039/D2CS00909A

LC-MS-Guided Isolation of Cyanogripeptides A–C, Cyclolipopeptides with β-Methyl-Leucine Residues, from an Actinoalloteichus cyanogriseus LHW52806

Shuai-Shuai Zhang, Lei Li, Ying Wu, Zong-Mei Wu, Can Kong, Li-Li Hong, Si Zhang, Xin-Li Lin, Hou-Wen Lin and Shu-Ping Wang

J. Nat. Prod., 2023, 86, 1708
DOI: 10.1021/acs.jnatprod.3c00127

Glycinocins E–H, Antimicrobial Lipopeptides Produced by a Streptomyces Strain

Ignacio Fernández-Pastor, Victor González-Menéndez, Ignacio González, Pilar Sanchez, Rachel Serrano, Thomas A Mackenzie, Daniel Oves-Costales, Manuel Casares Porcel, Olga Genilloud and Fernando Reyes

J. Nat. Prod., 2025, 88, 2127
DOI: 10.1021/acs.jnatprod.5c00740

Marine Streptomyces-Derived Lipids Inhibit SARS-CoV-2 3CLpro Through In Vitro and Predicted Multi-Site Binding Mechanisms

Doralyn S. Dalisay, Jomari C. Mateo, Jade Joshua R. Teodosio, Leighiara S. de Guzman, Neaven Bon Joy M. Marcial, Dion Paul C. Caspe, Lex Aliko P. Balida and Jamia Azdina Jamal

Pharmaceuticals, 2026, 19, 294
DOI: 10.3390/ph19020294

Structural diversity and applications of lipopeptide biosurfactants as biocontrol agents against phytopathogens: A review

Asma Sani, Wan-Qi Qin, Jia-Yi Li, Yi-Fan Liu, Lei Zhou, Shi-Zhong Yang and Bo-Zhong Mu

Microbiological Research, 2024, 278, 127518
DOI: 10.1016/j.micres.2023.127518

Isolation of Pseudonocardia strains associated with the shallow water hydrothermal vent crab Xenograpsus testudinatus from a metal-rich environment: Biochemical characterization and enzymatic characterization, molecular identification, antibacterial, antibiofilm and antioxidant activity

Johnthini Munir Ahamed, Hans-Uwe Dahms, Nikolaos V. Schizas, Arthur James Rathinam, Baghdad Ouddane and Yeou Lih Huang

Microbial Pathogenesis, 2025, 203, 107457
DOI: 10.1016/j.micpath.2025.107457

De novo design and synthesis of Pseudo-natural products via multicomponent reactions: Discovery of antiviral compounds targeting host lipid droplets

Agustín Galilea, Malena J. Solís Valderrama, Carlos A. Bueno, Marcelo Otero, Cybele C. García, Javier A. Ramírez, Andrea A. Barquero and Sofía L. Acebedo

Bioorganic Chemistry, 2025, 163, 108734
DOI: 10.1016/j.bioorg.2025.108734

Biomimetic antimicrobial peptides against gram-positive bacteria

Yu-Ting Li, Tian-Ci Wei, Jun-Xiao Yuan, Jia-Qi Feng, Pei-Pei Yang, Shu-Sheng Tang, Lei Wang and Hao Wang

Biomaterials, 2026, 329, 123916
DOI: 10.1016/j.biomaterials.2025.123916

Monaprenylindole A, a prenylated indole derivative from marine-derived Streptomyces sp., accelerates wound healing through the enhancement of keratinocyte motility via the modulation of cytoskeletal remodeling and growth factor pathways

Eun-Young Lee, Mücahit Varlı, Hiyoung Kim, Soyeong Kim, Seongeun Kang, Jungwook Chin, Hongchan An, Hangun Kim and Sang-Jip Nam

Bioorganic & Medicinal Chemistry Letters, 2026, 134, 130539
DOI: 10.1016/j.bmcl.2026.130539

Bacteria from the Amycolatopsis genus associated with a toxic bird secrete protective secondary metabolites

Elena Seibel, Soohyun Um, Kasun H. Bodawatta, Anna J. Komor, Tanya Decker, Janis Fricke, Robert Murphy, Gibson Maiah, Bulisa Iova, Hannah Maus, Tanja Schirmeister, Knud Andreas Jønsson, Michael Poulsen and Christine Beemelmanns

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-52316-3

Antifungal Action by Streptomyces globisporus Strain WB03 Against Fusarium cugenangense Causing Gastrodia elata Tuber Rot Disease

Jianxin Chen, Fengjinglin Wu, Youjiao Zhu, Nan Yang, Yuqian Wei, Huancheng Ma, Ziqiang Wu and Jianrong Wu

Plant Disease, 2025, 109, 2340
DOI: 10.1094/PDIS-09-24-1994-RE

WLIP, WLIPβ, and WLIPγ Produced from Pseudomonas canadensis Q3–1 via Precursor-Directed Biosynthesis and Their Roles on Biocontrol of Phytophthora Blight in Peppers

Zongwang Ma, Xiao Yang and Jun Sheng

J. Agric. Food Chem., 2024, 72, 4063
DOI: 10.1021/acs.jafc.3c07360

Bacillus lipopeptides as key players in rhizosphere chemical ecology

Guillaume Balleux, Monica Höfte, Anthony Arguelles-Arias, Magali Deleu and Marc Ongena

Trends in Microbiology, 2025, 33, 80
DOI: 10.1016/j.tim.2024.08.001

Anti-Magnaporthe oryzae Activity of Streptomyces bikiniensis HD-087 In Vitro and Bioinformatics Analysis of Polyketide Synthase Gene pksL

Jiahan Gang, Yuan Ping and Chunmei Du

Curr Microbiol, 2024, 81
DOI: 10.1007/s00284-024-03898-0

The rhizosphere as a hidden pharmacy: A review of bioactive compounds from plant–soil interfaces

Tamer Ali Sweellum, Dia Soltan, Hosam A. El Adawy, Deyala M. Naguib and Hanan Gahin

Rhizosphere, 2026, 37, 101298
DOI: 10.1016/j.rhisph.2026.101298

Efficient Stereochemical Analysis of Hydroxy Fatty Acids Using PGME and PAME Derivatization

Soohyun Um, Jaeyoun Lee and Seung Hyun Kim

Anal. Chem., 2025, 97, 12947
DOI: 10.1021/acs.analchem.5c01447

Bacterial Cyclic Lipopeptides as Triggers of Plant Immunity and Systemic Resistance Against Pathogens

Ning Ding, Hansong Dong and Marc Ongena

Plants, 2025, 14, 2644
DOI: 10.3390/plants14172644

Lipidation Engineering in Daptomycin Biosynthesis

Chang-Hun Ji, Sehong Park, Kunwoo Lee, Hyun-Woo Je and Hahk-Soo Kang

J. Am. Chem. Soc., 2024, 146, 30434
DOI: 10.1021/jacs.4c10966

Integrated genome and metabolome mining unveiled structure and biosynthesis of novel lipopeptides from a deep‐sea Rhodococcus

Costanza Ragozzino, Fortunato Palma Esposito, Carmine Buonocore, Pietro Tedesco, Daniela Coppola, Davide Paccagnella, Nadine Ziemert, Gerardo Della Sala and Donatella de de Pascale

Microbial Biotechnology, 2024, 17
DOI: 10.1111/1751-7915.70011

Antibacterial and biofilm disruptive nonribosomal lipopeptides from Streptomyces parvulus against multidrug-resistant bacterial infections

Shine Kadaikunnan, P. Vijayaragavan, M.A. Rathi, Balasubramanian Balamuralikrishnan, Naiyf S. Alharbi, V.K. Gopalakrishnan, Sumitha Purushothaman and Ravikumar Sivanesan

Journal of Infection and Public Health, 2024, 17, 450
DOI: 10.1016/j.jiph.2024.01.001

Genome-Led Discovery of the Antibacterial Cyclic Lipopeptide Kutzneridine A and Its Silent Biosynthetic Gene Cluster from Kutzneria Species

Francisco Javier Ortiz-López, Daniel Oves-Costales, Jaime Felipe Guerrero Garzón, Tetiana Gren, Eva Baggesgaard Sterndorff, Xinglin Jiang, Tue Sparholt Jo̷rgensen, Kai Blin, Ignacio Fernández-Pastor, José R. Tormo, Jesús Martín, Pilar Sánchez, Mercedes de la Cruz Moreno, Fernando Reyes, Olga Genilloud and Tilmann Weber

J. Nat. Prod., 2024, 87, 2515
DOI: 10.1021/acs.jnatprod.4c00633

Engineering of the start condensation domain with improved N‐decanoyl catalytic activity for daptomycin biosynthesis

Wenjie Fan, Lyubin Hu, Yu Yang, Panpan Liu, Yan Feng, Ruo‐Xu Gu and Qian Liu

Biotechnology Journal, 2024, 19
DOI: 10.1002/biot.202400202

Antifungal effects and biocontrol potential of lipopeptide-producing Streptomyces against banana Fusarium wilt fungus Fusarium oxysporum f. sp. cubense

Xiaxia Wang, Zhenghua Du, Chanxin Chen, Shuang Guo, Qianzhuo Mao, Wei Wu, Ruimei Wu, Wenbo Han, Peifeng Xie, Yiping Zeng, Wenna Shan, Zonghua Wang and Xiaomin Yu

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1177393

Computational Methods Reveal a Series of Cyclic and Linear Lichenysins and Surfactins from the Vietnamese Marine Sediment-Derived Streptomyces Strain G222

Andrea Castaldi, Bich Ngan Truong, Quyen Thi Vu, Thi Hong Minh Le, Arul Marie, Gaël Le Pennec, Florent Rouvier, Jean-Michel Brunel, Arlette Longeon, Van Cuong Pham, Thi Mai Huong Doan and Marie-Lise Bourguet-Kondracki

Molecules, 2024, 29, 1458
DOI: 10.3390/molecules29071458

Unlocking the potential of antimicrobial lipopeptides: a pathway to combat multidrug-resistant pathogens

Kaikai Lv, Yuxin Fang, Chenpeng He, Jiaoyu Xin, Chenyu Xue and Na Dong

Biochemical Pharmacology, 2026, 248, 117849
DOI: 10.1016/j.bcp.2026.117849

The Discovery of Nocacyclomycins A–H, Cyclic Lipodepsipeptides from Nocardia sungurluensis YINM00009

Tian-Peng Xie, Meng-Zhuo Yi, Rui Duan, Yin-Ting Zhang, Dan-Dan Xia, Yan Geng, Hai-Xia Dong, Min Yin, Hao Zhou and Zhong-Tao Ding

J. Nat. Prod., 2026, 89, 115
DOI: 10.1021/acs.jnatprod.5c01199

Classification, application, multifarious activities and production improvement of lipopeptides produced by Bacillus

Zhimin Wang, Chao Liu, Yingying Shi, Mingming Huang, Zunyang Song, Jesus Simal-Gandara, Ningyang Li and Jingying Shi

Critical Reviews in Food Science and Nutrition, 2024, 64, 7451
DOI: 10.1080/10408398.2023.2185588

Can natural preservatives serve as a new line of protective technology against bacterial pathogens in meat and meat products?

Changyong Cheng, Lingli Jiang, Xiaoliang Li, Houhui Song and Weihuan Fang

Food Quality and Safety, 2024, 8
DOI: 10.1093/fqsafe/fyad049

Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

Zijun Liu, Wenyan Sun, Zhe Hu, Wei Wang and Huawei Zhang

Marine Drugs, 2024, 22, 51
DOI: 10.3390/md22010051

Nitrogenous and Phenolic Compounds from Mangrove-Derived Actinomycete Streptomyces psammoticus

Xiao-Wei Luo, Gui-Hua Yang, Miao-Ping Lin, Hu-Mu Lu, Yong-Hong Liu and Xue-Feng Zhou

Chem Nat Compd, 2024, 60, 997
DOI: 10.1007/s10600-024-04503-3

Structurally Diverse Metabolites from the Marine‐Derived Streptomyces sp. DS‐27 Based on Two Different Culture Conditions

Feihang Yan, Jiebin Fang, Wanjing Ding, Xinyi Tang, Xiaoming Chen, Zhongjun Ma and Jinhui Wang

Chemistry & Biodiversity, 2023, 20
DOI: 10.1002/cbdv.202301017

Siderophore-synthesizing NRPS reprogram lipid metabolic profiles for phenotype and function changes of Arthrobotrys oligospora

Huiwen Liu, Liangyin Sun, Jintao Zhang, Yongzhong Wang and Hengqian Lu

World J Microbiol Biotechnol, 2024, 40
DOI: 10.1007/s11274-023-03840-9

Genome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis

Wan-Qi Qin, Yi-Fan Liu, Lei Zhou, Jin-Feng Liu, Dan Fei, Ke-Heng Xiang, Shi-Zhong Yang, Ji-Dong Gu and Bo-Zhong Mu

Microb Cell Fact, 2025, 24
DOI: 10.1186/s12934-025-02723-y

Engineered Biosynthesis through the Adenylation Domains from Nonribosomal Peptide Synthetases

Zhenhua Lu, Xiao-Huan Liu, Xinsong Yuan, Fei Liu and Tao Wang

CTMC, 2023, 23, 1973
DOI: 10.2174/1568026623666230601142757

The biocontrol roles of cyclic lipopeptide putisolvin produced from Pseudomonas capeferrum HN2-3 on the Phytophthora blight disease in cucumbers

Jun Sheng, Xiao Qin, Xiao Yang, Qian Liu and Zongwang Ma

J Plant Dis Prot, 2024, 131, 423
DOI: 10.1007/s41348-024-00874-5

Antiproliferative metabolites against glioma cells from the marine-associated actinomycete Streptomyces sp. ZZ735

Qianyin Dai, Mingzhu Ma, Nan Wang, Yufang Zhou and Zhizhen Zhang

Fitoterapia, 2024, 178, 106176
DOI: 10.1016/j.fitote.2024.106176

Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains

Weixia Ye, Kai Liu, Wei Liu, Xianbo Chen, Xuemin Ding, Haiyan Tian, Wenjun Zhang and Changsheng Zhang

Chinese Chemical Letters, 2025, 112293
DOI: 10.1016/j.cclet.2025.112293

Lipopeptide Engineering: From Natural Origins to Rational Design Against Antimicrobial Resistance

Shi-Yu Xie, Fang-Jing He, Ying-Ying Yang, Yan-Fei Tao and Xu Wang

Antibiotics, 2026, 15, 100
DOI: 10.3390/antibiotics15010100

The structure of the monobactam-producing thioesterase domain of SulM forms a unique complex with the upstream carrier protein domain

Ketan D. Patel, Ryan A. Oliver, Michael S. Lichstrahl, Rongfeng Li, Craig A. Townsend and Andrew M. Gulick

Journal of Biological Chemistry, 2024, 300, 107489
DOI: 10.1016/j.jbc.2024.107489

Antibacterial, Antifungal, and Cytotoxic Effects of Endophytic Streptomyces Species Isolated from the Himalayan Regions of Nepal and Their Metabolite Study

Ram Prabodh Yadav, Chen Huo, Rabin Budhathoki, Padamlal Budthapa, Bibek Raj Bhattarai, Monika Rana, Ki Hyun Kim and Niranjan Parajuli

Biomedicines, 2024, 12, 2192
DOI: 10.3390/biomedicines12102192

Teichoic acid biosynthesis enhances conjugation efficiency in Streptomyces: A key to unlocking DNA delivery into industrially relevant strains

Liyuan Han, Jiaxin Xu, Yuan Gu, Ruiying Feng, Shuo Liu, Qiujie Lu, Shuzhe Lv, Youming Zhang and Fu Yan

International Journal of Biological Macromolecules, 2025, 307, 142248
DOI: 10.1016/j.ijbiomac.2025.142248

The Physicochemical and Functional Properties of Biosurfactants: A Review

Salome Dini, Alaa El-Din A. Bekhit, Shahin Roohinejad, Jim M. Vale and Dominic Agyei

Molecules, 2024, 29, 2544
DOI: 10.3390/molecules29112544

Peptide surfactants with post-translational C-methylations that promote bacterial development

Chen Zhang, Yuchen Li, Ellysia N. Overton and Mohammad R. Seyedsayamdost

Nat Chem Biol, 2025, 21, 1069
DOI: 10.1038/s41589-025-01882-8

Role of fusaricidin a against pokkah boeng disease of sugarcane by affecting fungal signalling pathways and inducing Fusarium sacchari conidia death

Aiming Jiang, Xiang Xu, Zunwei Ke, Gaolei Cai, Xiaoyu Lu, Siru Yang, Jiguang Wei and Dewen Wu

Pest Management Science, 2026, 82, 2896
DOI: 10.1002/ps.70415

Unraveling the Biosynthetic Logic Behind the Production of Ramoplanin and Related Lipodepsipeptide Antibiotics

Oleksandr Yushchuk, Kseniia Zhukrovska, Elisa Binda and Flavia Marinelli

Fermentation, 2024, 10, 544
DOI: 10.3390/fermentation10110544