Hongfei He, Xuewen Zhang, Meng Deng, Yan Zhou, Hongwei Pang, Hui Yang, Jiazhen Lyu, Yuxin Feng, Xiangqin Geng, Xiaolan Guo, Guangcheng Luo and Bin Guo

Analytica Chimica Acta, 2025, 1335, 343457
DOI: 10.1016/j.aca.2024.343457

Isothermal Reciprocal Catalytic DNA Circuit for Sensitive Analysis of Kanamycin

Qingyang Si, Yumeng Li, Ziling Huang, Chuanyi Liu, Tianhui Jiao, Qingmin Chen, Xiaomei Chen, Quansheng Chen and Jie Wei

J. Agric. Food Chem., 2024, 72, 6754
DOI: 10.1021/acs.jafc.4c00261

Niosome-Assisted Delivery of DNA Fluorescent Probe with Optimized Strand Displacement for Intracellular MicroRNA21 Imaging

Zongwei Zhu, Hongqian Zhang, Xiaoxue Dong, Meng Lin and Chuanxu Yang

Biosensors, 2022, 12, 557
DOI: 10.3390/bios12080557

Detection of ATP from “fluorescence” to “enhanced fluorescence” based on metal-enhanced fluorescence triggered by aptamer nanoswitch

Mingqiu Zheng, Yafeng Kang, Da Liu, Chengyu Li, Bei Zheng and Hongwu Tang

Sensors and Actuators B: Chemical, 2020, 319, 128263
DOI: 10.1016/j.snb.2020.128263

Photoelectrochemical bioanalysis of antibiotics on rGO-Bi2WO6-Au based on branched hybridization chain reaction

Ruijin Zeng, Lijia Zhang, Lingshan Su, Zhongbin Luo, Qian Zhou and Dianping Tang

Biosensors and Bioelectronics, 2019, 133, 100
DOI: 10.1016/j.bios.2019.02.067

Stimuli‐Responsive DNA Circuits for High‐Performance Bioimaging Application

Qiong Wu, Mengqing Xu, Jinhua Shang, Shizhen He, Xiaoqing Liu and Fuan Wang

Advanced Sensor Research, 2023, 2
DOI: 10.1002/adsr.202200102

Construction of Multiply Guaranteed DNA Sensors for Biological Sensing and Bioimaging Applications

Hong Wang, Hanyan Zou and Fuan Wang

ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400266

Leveraging Demethylase Activation in DNA Circuits to Overcome Signal Leakage for Reliable MicroRNA Bioimaging

Yuchen Gao, Mengdi Yu, Jinhua Shang, Yuqian Jiang, Xiaoqing Liu and Fuan Wang

Small, 2025, 21
DOI: 10.1002/smll.202412843

Light-Controlled Recruitable Hybridization Chain Reaction on Exosome Vehicles for Highly Sensitive MicroRNA Imaging in Living Cells

Yanfei Zhang, Jun Chen, Huihui Yang, Wen Yin, Chunrong Li, Yuzhi Xu, Si-Yang Liu, Zong Dai and Xiaoyong Zou

Anal. Chem., 2022, 94, 9665
DOI: 10.1021/acs.analchem.2c00974

Label‐Free in Situ Monitoring of the DNA Hybridization Chain Reaction by Using Sequence‐Selective Minor‐Groove‐Binding Fluorophores

Takashi Sakamoto and Rikuto Yamada

ChemBioChem, 2019, 20, 1242
DOI: 10.1002/cbic.201800738

Highly Sensitive Assay of Methyltransferase Activity Based on an Autonomous Concatenated DNA Circuit

Chunxiao Li, Huimin Wang, Jinhua Shang, Xiaoqing Liu, Bifeng Yuan and Fuan Wang

ACS Sens., 2018, 3, 2359
DOI: 10.1021/acssensors.8b00738

In situ generation spatial confinement fluorescence RNA for sensitive and stable imaging of telomerase RNA in cells

Xia Li, Liqi Liu, Fei Yin, Yeling Liu, Shuling Xu, Wei Jiang, Rui Wang and Qingwang Xue

Sensors and Actuators B: Chemical, 2021, 345, 130414
DOI: 10.1016/j.snb.2021.130414

An enzyme-free and substrate-free electrochemical biosensor with robust porphyrin-based covalent-linked nanomaterial as nanoelectrocatalyst and efficient support for sensitive detection of uracil-DNA glycosylase

Tingting Liu, Lin Cui, Dekang Li, Wenqiang Gao, Lili Wu and Xiaomei Zhang

Biosensors and Bioelectronics, 2020, 154, 112014
DOI: 10.1016/j.bios.2020.112014

Recent Advances in DNA Nanostructures Applied in Sensing Interfaces and Cellular Imaging

Pu Zhang, Yu Ouyang, Ying Zhuo, Yaqin Chai and Ruo Yuan

Anal. Chem., 2023, 95, 407
DOI: 10.1021/acs.analchem.2c04540

Self-Assembled Growing DNA Tree Mediated by Exosomes for Amplified Imaging of Messenger RNA in Living Cells

Cheng Fang, Yuming Li, Song Hu, Hao Wang, Xiaoxia Chen and Xiaoli Zhu

Anal. Chem., 2021, 93, 8414
DOI: 10.1021/acs.analchem.1c00211

Colorimetric detection of miRNA-21 by DNAzyme-coupled branched DNA constructs

Elyas Hosseinzadeh, Hadi Ravan, Abbas Mohammadi and Hossein Pourghadamyari

Talanta, 2020, 216, 120913
DOI: 10.1016/j.talanta.2020.120913

Intracellular Signal Amplification for Ultrasensitive Detection and Imaging: Progress, Challenges, and Opportunities

Liang Gong, Xiuzhi Shan, Lin Xu, Li Tang and Xiao‐Bing Zhang

Analysis & Sensing, 2022, 2
DOI: 10.1002/anse.202200007

A Reciprocal-Amplifiable Fluorescence Sensing Platform via Replicated Hybridization Chain Reaction for Hosting Concatenated Multi-Ag Nanoclusters as Signal Reporter

Mengdie Li, Jiayang He, Xin Shang, Chunli Yang, Yuqing Zhang, Siyu Zuo, Ruo Yuan and Wenju Xu

Anal. Chem., 2022, 94, 16427
DOI: 10.1021/acs.analchem.2c03782

Modular Assembly of a Concatenated DNA Circuit for In Vivo Amplified Aptasensing

Qiong Wu, Lei Yang, Lingling Xie, Jinhua Shang, Shizhen He, Jing Liu and Fuan Wang

Small, 2022, 18
DOI: 10.1002/smll.202200983

Mass Spectrometric Multiplex Detection of MicroRNA and Protein Biomarkers for Liver Cancer

Yan Li, Zili Huang, Ziyan Li, Caixia Li, Rui Liu and Yi Lv

Anal. Chem., 2022, 94, 17248
DOI: 10.1021/acs.analchem.2c04171

Ultra-sensitive detection of microRNAs using an electrochemical biosensor based on a PNA-DNA2 three-way junction nanostructure and dual cascade isothermal amplification

Yang Zhao, Li Cheng, Mengjia Xu and Chao Zhao

Analytica Chimica Acta, 2025, 1345, 343755
DOI: 10.1016/j.aca.2025.343755

Label-free and ultrasensitive detection of environmental lead ions based on spatially localized DNA nanomachines driven by hyperbranched hybridization chain reaction

Xiao-Yu Li, Bo-Xi Zhou, Yu-Ling Xiao, Xin Liu, Yong-Qian Wang, Ming-Min Li and Jun-Ping Wang

Journal of Hazardous Materials, 2024, 476, 135115
DOI: 10.1016/j.jhazmat.2024.135115

Enzyme-free “on-off-on” photoelectrochemical biosensor based on cascaded quadratic amplification strategy for miRNA 141 detection

Fangjing Mo, Jingling Wu, Min Chen, Hui Meng, Qian Han and Yingzi Fu

Sensors and Actuators B: Chemical, 2019, 289, 269
DOI: 10.1016/j.snb.2019.03.044

The Recent Development of Hybridization Chain Reaction Strategies in Biosensors

Chuyan Zhang, Jing Chen, Rui Sun, Zhijun Huang, Zewei Luo, Chen Zhou, Mengfan Wu, Yixiang Duan and Yongxin Li

ACS Sens., 2020, 5, 2977
DOI: 10.1021/acssensors.0c01453

Adaption of an autonomously cascade DNA circuit for amplified detection and intracellular imaging of polynucleotide kinase with ultralow background

Jinhua Shang, Jie Wei, Qing Wang, Jing Wang, Yangjie Zhou, Shanshan Yu, Xiaoqing Liu and Fuan Wang

Biosensors and Bioelectronics, 2020, 152, 111994
DOI: 10.1016/j.bios.2019.111994

Enhanced Immunostimulatory Activity of a Cytosine-Phosphate-Guanosine Immunomodulator by the Assembly of Polymer DNA Wires and Spheres

Wenqian Yu, Junlin Sun, Feng Liu, Shuyi Yu, Zhen Xu, Fuan Wang and Xiaoqing Liu

ACS Appl. Mater. Interfaces, 2020, 12, 17167
DOI: 10.1021/acsami.9b21075

Nonlinear hybridization chain reaction-based functional DNA nanostructure assembly for biosensing, bioimaging applications

Zhuoer Zeng, Rong Zhou, Ruowei Sun, Xun Zhang, Zeneng Cheng, Chuanpin Chen and Qubo Zhu

Biosensors and Bioelectronics, 2021, 173, 112814
DOI: 10.1016/j.bios.2020.112814

Protein-free, ultrasensitive miRNA analysis based on an entropy-driven catalytic reaction switched on a smart-responsive DNAzyme dual-walker amplification strategy

Zhichao Fan, Xiang Zhao, Yan Dong, Jie Zhou, Yingxue Li, Junyi Wang, Yuchen Qi, Congcong Tan, Hua Yu and Jianjun Li

International Journal of Biological Macromolecules, 2022, 223, 931
DOI: 10.1016/j.ijbiomac.2022.11.084

Lighting-up RNA aptamer transcription synchronization amplification for ultrasensitive and label-free imaging of microRNA in single cells

Daxiu Li, Fang Yang, Ruo Yuan and Yun Xiang

Analytica Chimica Acta, 2020, 1102, 84
DOI: 10.1016/j.aca.2019.12.040

Ultrasensitive Electrochemiluminescence Detection of MicroRNA via One-Step Introduction of a Target-Triggered Branched Hybridization Chain Reaction Circuit

Yang Li, Cheng Zhi Huang and Yuan Fang Li

Anal. Chem., 2019, 91, 9308
DOI: 10.1021/acs.analchem.9b02580

Biosensors Based on the Au–Se Bond

Peng Gao, Yuanyuan Chen, Wei Pan, Na Li and Bo Tang

Anal. Chem., 2020, 92, 9441
DOI: 10.1021/acs.analchem.0c01624

A Smart Deoxyribozyme‐Programmable Catalytic DNA Circuit for High‐Contrast MicroRNA Imaging

Yuqiu He, Qing Wang, Chen Hong, Ruomeng Li, Jinhua Shang, Shanshan Yu, Xiaoqing Liu and Fuan Wang

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202307418

Recent Advances in Biosensors Based on Hybridization Chain Reaction and Silver Nanoclusters

Zheng Wei Wong and Siu Yee New

Small Methods, 2025, 9
DOI: 10.1002/smtd.202401436

Non‐Classical Hybridization Chain Reactions

Shiyuan Liu, Jiaoli Wang, Ying Pu and Jin Huang

Chemistry An Asian Journal, 2026, 21
DOI: 10.1002/asia.70625

Recent progress in the development of DNA-based biosensors integrated with hybridization chain reaction or catalytic hairpin assembly

Liuting Mo, Wanqi He, Ziyi Li, Danlian Liang, Runhong Qin, Mingxiu Mo, Chan Yang and Weiying Lin

Front. Chem., 2023, 11
DOI: 10.3389/fchem.2023.1134863

A High-Efficiency Autocatalysis-Oriented Cascade Circuit via Reciprocal Hug-Amplification for Assay-to-Treat Application

Chunli Yang, Yuqing Zhang, Zhaorong Mo, Jiayang He, Zhihan Zhang, Yaqin Chai, Ruo Yuan and Wenju Xu

Anal. Chem., 2025, 97, 1816
DOI: 10.1021/acs.analchem.4c05701

A Deoxyribozyme-Initiated Self-Catalytic DNA Machine for Amplified Live-Cell Imaging of MicroRNA

Yeqing Wan, Gaiping Li, Lina Zou, Hong Wang, Qing Wang, Kaiyue Tan, Xiaoqing Liu and Fuan Wang

Anal. Chem., 2021, 93, 11052
DOI: 10.1021/acs.analchem.1c02596

Tracing cellular interaction of circRNA-miRNA axis with Cu metal-organic framework supported DNA cascade assembly

Gang Wang, Tao Cheng, Hongxiu Yuan, Fangbo Zou, Peng Miao and Jin Jiao

Biosensors and Bioelectronics, 2023, 228, 115226
DOI: 10.1016/j.bios.2023.115226

Construction of a self-sufficient DNA circuit for amplified detection of kanamycin

Yumeng Li, Qingyang Si, Chuanyi Liu, Ziling Huang, Qingmin Chen, Tianhui Jiao, Xiaomei Chen, Quansheng Chen and Jie Wei

Food Chemistry, 2023, 418, 136048
DOI: 10.1016/j.foodchem.2023.136048

DNA Nanomachines for Identifying Cancer Biomarkers in Body Fluids and Cells

Zaizai Dong, Xinying Xue, Hailun Liang, Jingjiao Guan and Lingqian Chang

Anal. Chem., 2021, 93, 1855
DOI: 10.1021/acs.analchem.0c03518

Highly sensitive miRNA-21 detection with enzyme-free cascade amplification biosensor

Qiuyan Huang, Kun Wang and Yuan Wang

Talanta, 2024, 273, 125928
DOI: 10.1016/j.talanta.2024.125928

Avenues Toward microRNA Detection In Vitro: A Review of Technical Advances and Challenges

Chu-shu Zhu, Lingyun Zhu, De-an Tan, Xin-yuan Qiu, Chuan-yang Liu, Si-si Xie and Lv-yun Zhu

Computational and Structural Biotechnology Journal, 2019, 17, 904
DOI: 10.1016/j.csbj.2019.06.018

An Autonomous Nonenzymatic Concatenated DNA Circuit for Amplified Imaging of Intracellular ATP

Yangjie Zhou, Lei Yang, Jie Wei, Kang Ma, Xue Gong, Jinhua Shang, Shanshan Yu and Fuan Wang

Anal. Chem., 2019, 91, 15229
DOI: 10.1021/acs.analchem.9b04126

Zipper-Confined DNA Nanoframe for High-Efficient and High-Contrast Imaging of Heterogeneous Tumor Cell

Mengxuan Zhang, Tiantian Yang, Ruiwei Hu, Menghan Li, Yuanjie Liu, Wen He, Lina Zhao, Yuan Xu, Minghui Guo, Shijia Ding, Junman Chen and Wei Cheng

Anal. Chem., 2024, 96, 2253
DOI: 10.1021/acs.analchem.3c05619

Sensitive detection of microRNA using a label-free copper nanoparticle system with polymerase-based signal amplification

Jiangnan Lu, Shuping Liang, Li Tan, Kun Hu, Shulin Zhao and Jianniao Tian

Anal Bioanal Chem, 2020, 412, 7179
DOI: 10.1007/s00216-020-02850-y

Detection of uranyl ions by single-hairpin based self-hybridization chain reaction

Fengyi Lin, Yuxin Cheng, Min Li, Zhi Li and Jianyuan Dai

Talanta, 2025, 285, 127374
DOI: 10.1016/j.talanta.2024.127374

Construction of an Exonuclease III-Propelled Integrated DNAzyme Amplifier for Highly Efficient microRNA Detection and Intracellular Imaging with Ultralow Background

Yangjie Zhou, Shanshan Yu, Jinhua Shang, Yingying Chen, Qing Wang, Xiaoqing Liu and Fuan Wang

Anal. Chem., 2020, 92, 15069
DOI: 10.1021/acs.analchem.0c03073

Programmable Assembly of Multivalent DNA‐Protein Superstructures for Tumor Imaging and Targeted Therapy

Zhen Xu, Tianhui Shi, Fengye Mo, Wenqian Yu, Yu Shen, Qunying Jiang, Fuan Wang and Xiaoqing Liu

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202211505

Dictated Emergence of Nucleic Acid-Based Constitutional Dynamic Networks by DNA Replication Machineries

Zhixin Zhou, Jianbang Wang and Itamar Willner

J. Am. Chem. Soc., 2021, 143, 241
DOI: 10.1021/jacs.0c09892

Signal amplification strategy of DNA self-assembled biosensor and typical applications in pathogenic microorganism detection

Yuxin Bai, Pingyao Xu, Shi Li, Dongsheng Wang, Kaijiong Zhang, Dongming Zheng, Daifan Yue, Guiji Zhang, Shuya He, Yan Li, Haimin Zou and Yao Deng

Talanta, 2024, 272, 125759
DOI: 10.1016/j.talanta.2024.125759

Miniature Hierarchical DNA Hybridization Circuit for Amplified Multiplexed MicroRNA Imaging

Ruomeng Li, Fengzhe Li, Yanping Zhang, Yuqiu He, Yushi Wang and Fuan Wang

Anal. Chem., 2023, 95, 3848
DOI: 10.1021/acs.analchem.2c05373

Engineering of a Self-Regulatory Bidirectional DNA Assembly Circuit for Amplified MicroRNA Imaging

Xue Gong, Jiajia Zhang, Pu Zhang, Yuqian Jiang, Lianzhe Hu, Zhongwei Jiang, Fuan Wang and Yi Wang

Anal. Chem., 2023, 95, 18731
DOI: 10.1021/acs.analchem.3c02822

A one-step assay technique using a novel nucleic acid-ER/HER2 hybrid probe for in-situ detection of molecular subtypes of breast cancer

Ying Zhang, Wei Lin, Bing Wu, Danqing Liu, Yue Chen, Yanfang Xu, Zhenyu Lin, Sunwang Xu and Fei Huang

Sensors and Actuators B: Chemical, 2025, 444, 138345
DOI: 10.1016/j.snb.2025.138345

Biomedical Utility of Non‐Enzymatic DNA Amplification Reaction: From Material Design to Diagnosis and Treatment

Ye Chen, Zhiqiang Liu, Bowen Zhang, Haoyan Wu, Xiaoying Lv, Yuxin Zhang and Yunfeng Lin

Small, 2024, 20
DOI: 10.1002/smll.202404641

Dispersion-to-localization of catalytic hairpin assembly for sensitive sensing and imaging microRNAs in living cells from whole blood

Huijie Bai, Yurong Yan, Dandan Li, Ningke Fan, Wenqian Cheng, Wei Yang, Huangxian Ju, Xinmin Li and Shijia Ding

Biosensors and Bioelectronics, 2022, 198, 113821
DOI: 10.1016/j.bios.2021.113821

Lighting Up MicroRNA in Living Cells by the Disassembly of Lock‐Like DNA‐Programmed UCNPs‐AuNPs through the Target Cycling Amplification Strategy

Keying Zhang, Shuting Song, Shan Huang, Lin Yang, Qianhao Min, Xingcai Wu, Feng Lu and Jun‐Jie Zhu

Small, 2018, 14
DOI: 10.1002/smll.201802292

Construction of an autocatalysis-driven DNA circuit for highly efficient detection of H5N1 oligonucleotide

Yumeng Li, Chuanyi Liu, Qingyang Si, Tianhui Jiao, Qingmin Chen, Xiaomei Chen, Quansheng Chen and Jie Wei

Sensors and Actuators B: Chemical, 2023, 394, 134393
DOI: 10.1016/j.snb.2023.134393

A cyclic feedback DNA circuit for high-performance detection of aflatoxin B1

Zhigang Li, Xiaojiao Dai, Ran Li, Yi Xu, Qingmin Chen, Xiaomei Chen, Quansheng Chen and Jie Wei

Sensors and Actuators B: Chemical, 2026, 453, 139543
DOI: 10.1016/j.snb.2026.139543

A Smart Deoxyribozyme‐Programmable Catalytic DNA Circuit for High‐Contrast MicroRNA Imaging

Yuqiu He, Qing Wang, Chen Hong, Ruomeng Li, Jinhua Shang, Shanshan Yu, Xiaoqing Liu and Fuan Wang

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202307418

Signal Amplification in Living Cells: A Review of microRNA Detection and Imaging

Hanyong Peng, Ashley M. Newbigging, Michael S. Reid, Jagdeesh S. Uppal, Jingyang Xu, Hongquan Zhang and X. Chris Le

Anal. Chem., 2020, 92, 292
DOI: 10.1021/acs.analchem.9b04752

MicroRNA Triggered DNA “Nano Wheel” for Visualizing Intracellular microRNA via Localized DNA Cascade Reaction

Fan Yang, Yaru Cheng, Yu Cao, Yiyi Zhang, Haifeng Dong, Huiting Lu and Xueji Zhang

Anal. Chem., 2019, 91, 9828
DOI: 10.1021/acs.analchem.9b01487

Mini review: Enzyme-based DNA synthesis and selective retrieval for data storage

Eojin Yoo, Donghui Choe, Jongoh Shin, Suhyung Cho and Byung-Kwan Cho

Computational and Structural Biotechnology Journal, 2021, 19, 2468
DOI: 10.1016/j.csbj.2021.04.057

Light-Activated Nanodevice for On-Demand Imaging of miRNA in Living Cells via Logic Assembly

Huimin Zhou, Yao Jiang, Wenjing Zhao and Shusheng Zhang

ACS Appl. Mater. Interfaces, 2022, 14, 13070
DOI: 10.1021/acsami.2c00376

Advances of fluorescent DNA nanostructures in biomedical applications

Xiaotong Shen, Mengyu Cao, Xiner Xing, Jin Ouyang and Na Na

TIMS, 2024, 2, 100064
DOI: 10.59717/j.xinn-mater.2024.100064

Amplified MicroRNA Detection and Intracellular Imaging Based on an Autonomous and Catalytic Assembly of DNAzyme

Lei Yang, Qiong Wu, Yuqi Chen, Xiaoqing Liu, Fuan Wang and Xiang Zhou

ACS Sens., 2019, 4, 110
DOI: 10.1021/acssensors.8b01000

Integration of Isothermal Enzyme‐Free Nucleic Acid Circuits for High‐Performance Biosensing Applications

Siyuan Wang, Jinhua Shang, Bingyue Zhao, Huimin Wang, Changying Yang, Xiaoqing Liu and Fuan Wang

ChemPlusChem, 2023, 88
DOI: 10.1002/cplu.202300432

Near-Infrared Light Activated Nucleic Acid Cascade Recycling Amplification for Spatiotemporally Controllable Signal Amplified mRNA Imaging

Ruilin Duan, Tao Li, Zhijuan Duan, Fujian Huang and Fan Xia

Anal. Chem., 2020, 92, 5846
DOI: 10.1021/acs.analchem.9b05494

A proteinase-free DNA replication machinery for in vitro and in vivo amplified MicroRNA imaging

Jie Wei, Huimin Wang, Xue Gong, Qing Wang, Hong Wang, Yangjie Zhou and Fuan Wang

Nucleic Acids Research, 2020, 48, e60
DOI: 10.1093/nar/gkaa250

Target biorecognition-triggered assembly of a G-quadruplex DNAzyme-decorated nanotree for the convenient and ultrasensitive detection of antibiotic residues

Haiyan Wang, Yiming Xie, Yujia Wang and Guosong Lai

Science of The Total Environment, 2022, 813, 152629
DOI: 10.1016/j.scitotenv.2021.152629

Toehold Strand Displacement-Mediated Exponential HCR for Highly Sensitive and Specific Analysis of miRNA in Living Cells

Mengxu Sun, Qianying Zhou, Jing Peng, Simin Liu, Jiaxin Luo, Lingling Bai, Wen-Jun Duan, Jin-Xiang Chen, Zong Dai and Jun Chen

Anal. Chem., 2024, 96, 9078
DOI: 10.1021/acs.analchem.4c00594

Branching Crisscross Polymerization of Single-Stranded DNA Slats

Jie Deng, Dionis Minev, Anastasia Ershova and William M. Shih

J. Am. Chem. Soc., 2024, 146, 9216
DOI: 10.1021/jacs.4c00097

Rapid and enzyme-free signal amplification for fluorescent detection of microRNA via localized catalytic hairpin assembly on gold nanoparticles

Qiang Liu, Mei Liu, Yan Jin and Baoxin Li

Talanta, 2022, 242, 123142
DOI: 10.1016/j.talanta.2021.123142

Label-free and self-assembled fluorescent DNA nanopompom for determination of miRNA-21

Nandi Chen, Junyu Li, Xianzhen Feng, Yanping Yang, Li Zhu, Xiaomeng Chen, Xuan Liu, Yang Li, Cunchuan Wang and Ligang Xia

Microchim Acta, 2020, 187
DOI: 10.1007/s00604-020-04377-6

Deoxynivalenol (DON)-Triggered Dual-Color Composite Probe Based on Gold Nanoclusters for Simultaneous Imaging of DON and miR-34a in Living Cells

Wenyan Yu, Lixin Kang, Xianfeng Lin, Nuo Duan, Dichen Ying, Zhouping Wang and Shijia Wu

Anal. Chem., 2023, 95, 18611
DOI: 10.1021/acs.analchem.3c04630

Advancing Multiple Detection in RT-LAMP with a Specific Probe Assembled from Plural Three-Way-Junction Structures

Yi Sun, Sicai Zhang, Lijuan Qi, Xiaojun Zhang, Meiting Yang, Zhijun Guo, Zhenxin Wang and Yan Du

Anal. Chem., 2023, 95, 17808
DOI: 10.1021/acs.analchem.3c03877

Concatenated Catalytic Hairpin Assembly/Hyperbranched Hybridization Chain Reaction Based Enzyme-Free Signal Amplification for the Sensitive Photoelectrochemical Detection of Human Telomerase RNA

Yanxin Chu, An-Ping Deng, Wenjing Wang and Jun-Jie Zhu

Anal. Chem., 2019, 91, 3619
DOI: 10.1021/acs.analchem.8b05610

Click Chemistry Actuated Exponential Amplification Reaction Assisted CRISPR–Cas12a for the Electrochemical Detection of MicroRNAs

Hongguo Wei, Shengjun Bu, Ze Wang, Hongyu Zhou, Xue Li, Jiaqi Wei, Xiuxia He and Jiayu Wan

ACS Omega, 2022, 7, 35515
DOI: 10.1021/acsomega.2c01930

Novel and sensitive electrochemical/fluorescent dual-mode biosensing platform based on the cascaded cyclic amplification of enzyme-free DDSA and functional nucleic acids

Yu Xue, Haopu Xie, Yu Wang, Sinuo Feng, Jian Sun, Jianshe Huang and Xiurong Yang

Biosensors and Bioelectronics, 2022, 218, 114762
DOI: 10.1016/j.bios.2022.114762

Hairpin DNA-Mediated isothermal amplification (HDMIA) techniques for nucleic acid testing

Idorenyin A. Iwe, Wenqin Li, Zhigang Li and Jiahao Huang

Talanta, 2021, 226, 122146
DOI: 10.1016/j.talanta.2021.122146

An Ultrasensitive Bunge Bedstraw Herb Type DNA Machine for Absolute Quantification of Mrna in Single Cell

Shulin Zhao, Chunhuan Xu, Jingjin Zhao, Shengyu Chen, Ivan Sakharov and Shengqiang Hu

SSRN Journal, 2022
DOI: 10.2139/ssrn.4183372

Target-Induced Cascade Amplification for Homogeneous Virus Detection

Mingyuan Du, Guobin Mao, Songbai Tian, Yucheng Liu, Jiao Zheng, Xianliang Ke, Zhenhua Zheng, Hanzhong Wang, Xinghu Ji and Zhike He

Anal. Chem., 2019, 91, 15099
DOI: 10.1021/acs.analchem.9b03805

Ratiometric fluorescence sensing of copper ion and enzyme activity by nanoprobe-mediated autocatalytic reaction and catalytic cascade reaction

Ping Dong, Yahua Liu, Yun Zhao, Wenxiao Wang, Min Pan, Yu Liu and Xiaoqing Liu

Sensors and Actuators B: Chemical, 2020, 310, 127873
DOI: 10.1016/j.snb.2020.127873

Construction of an Autonomous Nonlinear Hybridization Chain Reaction for Extracellular Vesicles-Associated MicroRNAs Discrimination

Qiong Wu, Hong Wang, Keke Gong, Jinhua Shang, Xiaoqing Liu and Fuan Wang

Anal. Chem., 2019, 91, 10172
DOI: 10.1021/acs.analchem.9b02181

Imaging of Cancer Cells and Dictated Cytotoxicity Using Aptamer‐Guided Hybridization Chain Reaction (HCR)‐Generated G‐Quadruplex Chains

Amily Fang‐Ju Jou, Yi‐Te Chou, Itamar Willner and Ja‐an Annie Ho

Angew Chem Int Ed, 2021, 60, 21673
DOI: 10.1002/anie.202106147

Hairpin allosteric molecular beacons-based cascaded amplification for effective detection of lung cancer-associated microRNA

Cheng Zheng, Xuemei Hu, Shujuan Sun, Lingye Zhu, Ning Wang, Jing Zhang, Guoqiao Huang, Yuzhe Wang, Xiaoying Huang, Liangxing Wang and Zhifa Shen

Talanta, 2022, 244, 123412
DOI: 10.1016/j.talanta.2022.123412

An ultrasensitive bunge bedstraw herb type DNA machine for absolute quantification of mRNA in single cell

Chunhuan Xu, Jingjin Zhao, Shengyu Chen, Ivan Yu Sakharov, Shengqiang Hu and Shulin Zhao

Biosensors and Bioelectronics, 2022, 217, 114702
DOI: 10.1016/j.bios.2022.114702

Emerging isothermal amplification technologies for microRNA biosensing: Applications to liquid biopsies

Guillaume Gines, Roberta Menezes, Wenjin Xiao, Yannick Rondelez and Valerie Taly

Molecular Aspects of Medicine, 2020, 72, 100832
DOI: 10.1016/j.mam.2019.11.002

Catalyst‐Accelerated Circular Cascaded DNA Circuits: Simpler Design, Faster Speed, Higher Gain

Jiaoli Wang, Xiaoxiao Fu, Shiyuan Liu, Ruiting Liu, Jing Li, Kemin Wang and Jin Huang

Small, 2023, 19
DOI: 10.1002/smll.202205903

Fluorimetric monitoring of vancomycin using an allosteric probe-initiated sensing platform

Jinshan Yuan, Guoming Xie, Junjie Li, Yaxing Xie, Yuan Yao, Jianhong Zhang, Yulei Hou and Hui Chen

Analytica Chimica Acta, 2023, 1269, 341431
DOI: 10.1016/j.aca.2023.341431

Modular Assembled Localized Hybridization Chain Reaction for In Situ mRNA Amplified Imaging

Shiyuan Liu, Jiaoli Wang, Yu Chen, Jiahao Fan, Bin Du, Ruiting Liu, Xiaobei Zhu, Kemin Wang, Nuli Xie and Jin Huang

Nano Lett., 2024, 24, 11590
DOI: 10.1021/acs.nanolett.4c03099

The label- and laser-free autocatalytic nucleic acid amplification reaction for the sensitive miRNA detection

Siyuan Wang, Bingyue Zhao, Min Shang, Yaqi Liu, Hanghang Liu, Jiabing Ran, Zhangshuang Deng, Changying Yang and Huimin Wang

Microchemical Journal, 2025, 212, 113253
DOI: 10.1016/j.microc.2025.113253

The Trend of Nonenzymatic Nucleic Acid Amplification: Strategies and Diagnostic Application

Junyou Li, Ting Li, Zheng Zou and Hung-Wing Li

Precision Chemistry, 2025, 3, 187
DOI: 10.1021/prechem.4c00100

Ultrasensitive photoelectrochemical detection of microcystin-LR based on hybridization chain reaction assisted exciton-plasmon interaction and enzymatic biocatalytic precipitation

Jie Wei, Xuan Xie, Weidan Chang, Zhuohong Yang and Yingju Liu

Sensors and Actuators B: Chemical, 2018, 276, 180
DOI: 10.1016/j.snb.2018.08.099

Multiplexed Imaging with Coordination Nanoparticles for Cancer Diagnosis and Therapy

Jie Feng, Zhen Xu, Dan Luo and Xiaoqing Liu

ACS Appl. Bio Mater., 2020, 3, 713
DOI: 10.1021/acsabm.9b01038

Low-Noise Nanopore Enables In-Situ and Label-Free Tracking of a Trigger-Induced DNA Molecular Machine at the Single-Molecular Level

Zhentong Zhu, Xiaozheng Duan, Qiao Li, Ruiping Wu, Yesheng Wang and Bingling Li

J. Am. Chem. Soc., 2020, 142, 4481
DOI: 10.1021/jacs.0c00029

Combined microRNA and mRNA detection in mammalian retinas by in situ hybridization chain reaction

Pei Zhuang, Huanqing Zhang, Ryan M. Welchko, Robert C. Thompson, Shunbin Xu and David L. Turner

Sci Rep, 2020, 10
DOI: 10.1038/s41598-019-57194-0

Simple, Amplified, and Multiplexed Detection of MicroRNAs Using Time-Gated FRET and Hybridization Chain Reaction

Jiajia Guo, Carlos Mingoes, Xue Qiu and Niko Hildebrandt

Anal. Chem., 2019, 91, 3101
DOI: 10.1021/acs.analchem.8b05600

An enzyme-free amplification strategy for sensitive assay of circulating tumor DNA based on wheel-like catalytic hairpin assembly and frame hybridization chain reaction

Shihua Luo, Ye Zhang, Guoni Huang, Bo Situ, Xinyi Ye, Maliang Tao, Yifang Huang, Bo Li, Xiujuan Jiang, Qian Wang and Lei Zheng

Sensors and Actuators B: Chemical, 2021, 338, 129857
DOI: 10.1016/j.snb.2021.129857

Recent advance in the sensing of biomarker transcription factors

Bingzhi Li, Siying Xie, Anqi Xia, Tiying Suo, He Huang, Xing Zhang, Yue Chen and Xuemin Zhou

TrAC Trends in Analytical Chemistry, 2020, 132, 116039
DOI: 10.1016/j.trac.2020.116039

Minimizing Leakage in Stacked Strand Exchange Amplification Circuits

Erhu Xiong, Dongbao Yao, Andrew D. Ellington and Sanchita Bhadra

ACS Synth. Biol., 2021, 10, 1277
DOI: 10.1021/acssynbio.0c00615

Electrochemical Biosensor for MicroRNA Detection Based on Cascade Hybridization Chain Reaction

Meijuan Liang, Min Pan, Jialing Hu, Fuan Wang and Xiaoqing Liu

ChemElectroChem, 2018, 5, 1380
DOI: 10.1002/celc.201800255

Enzyme-free dual-amplification strategy for the rapid, single-step detection of nucleic acids based on hybridization chain reaction initiated entropy-driven circuit reaction

Dongmei Huang, Xinmin Li, Bo Shen, Jia Li, Xiaojuan Ding, Xiaoyan Zhou, Bin Guo, Wei Cheng and Shijia Ding

Sensors and Actuators B: Chemical, 2018, 273, 393
DOI: 10.1016/j.snb.2018.06.068

Novel Fluorescence Switch for MicroRNA Imaging in Living Cells Based on DNAzyme Amplification Strategy

Peixin Li, Min Wei, Fen Zhang, Juan Su, Wei Wei, Yuanjian Zhang and Songqin Liu

ACS Appl. Mater. Interfaces, 2018, 10, 43405
DOI: 10.1021/acsami.8b15330

Construction of an Enzyme-Free Initiator-Replicated Hybridization Chain Reaction Circuit for Amplified Methyltransferase Evaluation and Inhibitor Assay

Jinhua Shang, Chunxiao Li, Fengzhe Li, Qing Wang, Bifeng Yuan and Fuan Wang

Anal. Chem., 2021, 93, 2403
DOI: 10.1021/acs.analchem.0c04356

Branched Hybridization Chain Reaction Circuit for Ultrasensitive Localizable Imaging of mRNA in Living Cells

Lan Liu, Jin-Wen Liu, Han Wu, Xiang-Nan Wang, Ru-Qin Yu and Jian-Hui Jiang

Anal. Chem., 2018, 90, 1502
DOI: 10.1021/acs.analchem.7b04848

Programmable Assembly of Multivalent DNA‐Protein Superstructures for Tumor Imaging and Targeted Therapy

Zhen Xu, Tianhui Shi, Fengye Mo, Wenqian Yu, Yu Shen, Qunying Jiang, Fuan Wang and Xiaoqing Liu

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202211505

Precision Tumor Recognition in Clear Cell Renal Cell Carcinoma: A qHCR Platform Leveraging Tetrahedral DNA Nanostructures for Rapid Molecular Diagnosis

Chenyu Wang, Yongji Li, Haorui Li, Jing Wang, Weida Liu, Jiarui Su, Ronghao Cui, Siwei Yang, Zhili Yao, Qingnan Li, Guimei Han, Jianxi Shi, Zheng Zhang, Zhun Wang, Zhifei Liu, Yegang Chen, Shuangqing Liu, Yan Zhao, Shaosan Kang, Deming Kong and Qiliang Cai

Aggregate, 2025, 6
DOI: 10.1002/agt2.70151

Strand displacement dual amplification miRNAs strategy with FRET between NaYF4:Yb,Tm/Er upconversion nanoparticles and Ti3C2 nanosheets

Feng Chen, Qiujun Lu, Youyu Zhang and Shouzhuo Yao

Sensors and Actuators B: Chemical, 2019, 297, 126751
DOI: 10.1016/j.snb.2019.126751

Tag-Free Methodology for Ultrasensitive Biosensing of miRNA Based on Intrinsic Isotope Detection

Jianyu Hu, Ziyan Li, Hu Zhang, Rui Liu and Yi Lv

Anal. Chem., 2020, 92, 8523
DOI: 10.1021/acs.analchem.0c01295

Isothermal nucleic acid amplification based microfluidic “lab-on-a-chip” for the detection of pathogenic bacteria and viruses in agri-foods

Yuxiao Lu, Jingbin Zhang, Xiaonan Lu and Qian Liu

Trends in Food Science & Technology, 2024, 148, 104482
DOI: 10.1016/j.tifs.2024.104482

Quadruple cascade strand displacement amplification reaction mediated polyfluorene derivative-based multiple FRET for synchronous determination of multiple biomarkers

Yuanyuan Zhang, Jian Wei, Jinwen Zhao, Ying He, Ruo Yuan and Shihong Chen

Sensors and Actuators B: Chemical, 2023, 380, 133373
DOI: 10.1016/j.snb.2023.133373

Study on the Functionalization and Signaling Efficiency of the Hybridization Chain Reaction Using Traditional and Single Molecular Characterizations

Chunmiao Yu, Yesheng Wang, Ruiping Wu, Zhentong Zhu and Bingling Li

ACS Appl. Bio Mater., 2021, 4, 3649
DOI: 10.1021/acsabm.1c00136

Hierarchical Hybridization Chain Reaction for Amplified Signal Output and Cascade DNA Logic Circuits

Wen Yi Lv, Chun Hong Li, Yuan Fang Li, Shu Jun Zhen and Cheng Zhi Huang

Anal. Chem., 2021, 93, 3411
DOI: 10.1021/acs.analchem.0c04483

Early and In-Stage Diagnosis of Alzheimer’s Disease by the Simultaneous Fluorescent Determination of the Biomarkers miR-501-3p and miR-455-3p with Carbon Quantum Dots in Serum

Yaxin Guo, Dan Liu, Qing Yang, Wei Shi, Zhihui Yang, Jia Chen and Juan Xiang

Analytical Letters, 2022, 55, 1453
DOI: 10.1080/00032719.2021.2008950

A target-initiated autocatalytic 3D DNA nanomachine for high-efficiency amplified detection of MicroRNA

Peng Yang, Haoran Chen, Quanjing Zhu, Zhaopeng Chen, Zezhou Yang, Ruo Yuan, Yan Li and Wenbin Liang

Talanta, 2022, 240, 123219
DOI: 10.1016/j.talanta.2022.123219

Light Scattering Technology-Combined Ligation-Dependent Loop-Mediated Isothermal Amplification (LL-LAMP) for Sensitive Detection of RNA

Honghong Wang, Shuhui Wang, Hui Wang, Yuanwen Liang, Yuting Jia and Zhengping Li

ACS Omega, 2022, 7, 19957
DOI: 10.1021/acsomega.2c01759

A Smart, Autocatalytic, DNAzyme Biocircuit for in Vivo, Amplified, MicroRNA Imaging

Jie Wei, Huimin Wang, Qiong Wu, Xue Gong, Kang Ma, Xiaoqing Liu and Fuan Wang

Angewandte Chemie, 2020, 132, 6021
DOI: 10.1002/ange.201911712

Imaging of Cancer Cells and Dictated Cytotoxicity Using Aptamer‐Guided Hybridization Chain Reaction (HCR)‐Generated G‐Quadruplex Chains

Amily Fang‐Ju Jou, Yi‐Te Chou, Itamar Willner and Ja‐an Annie Ho

Angewandte Chemie, 2021, 133, 21841
DOI: 10.1002/ange.202106147

Multifunctional Plasmonic Core-Satellites Nanoprobe for Cancer Diagnosis and Therapy Based on a Cascade Reaction Induced by MicroRNA

Duoduo Zhang, Kan Wang, Wei Wei, Yong Liu and Songqin Liu

Anal. Chem., 2021, 93, 9521
DOI: 10.1021/acs.analchem.1c01539

Highly sensitive detection of hepatitis C virus DNA by using a one-donor-four-acceptors FRET probe

Ping Zeng, Peng Hou, Chun Ju Jing and Cheng Zhi Huang

Talanta, 2018, 185, 118
DOI: 10.1016/j.talanta.2018.03.053

Recent Progress in DNA Hybridization Chain Reaction Strategies for Amplified Biosensing

Hua Chai, Wenbo Cheng, Dayong Jin and Peng Miao

ACS Appl. Mater. Interfaces, 2021, 13, 38931
DOI: 10.1021/acsami.1c09000

High-performance biosensing based on autonomous enzyme-free DNA circuits

Hong Wang, Huimin Wang, Itamar Willner and Fuan Wang

Top Curr Chem (Z), 2020, 378
DOI: 10.1007/s41061-020-0284-x

Chemical and Biological Sensing Using Hybridization Chain Reaction

Erik E. Augspurger, Muhit Rana and Mehmet V. Yigit

ACS Sens., 2018, 3, 878
DOI: 10.1021/acssensors.8b00208

DNA Nanofirecrackers Assembled through Hybridization Chain Reaction for Ultrasensitive SERS Immunoassay of Prostate Specific Antigen

Jia Ru Wang, Chang Xia, Lin Yang, Yuan Fang Li, Chun Mei Li and Cheng Zhi Huang

Anal. Chem., 2020, 92, 4046
DOI: 10.1021/acs.analchem.9b05648

The mechanism and improvements to the isothermal amplification of nucleic acids, at a glance

Rozi Asadi and Hamidreza Mollasalehi

Analytical Biochemistry, 2021, 631, 114260
DOI: 10.1016/j.ab.2021.114260

Recent advances in isothermal amplification techniques coupled with clustered regularly interspaced short palindromic repeat/Cas systems

Miao Liu, Yajun Hou, Yuhang Cheng, Ziyun Li, Jiawei Zeng, Li Li, Jinyong Luo and Bo Shen

Interdisciplinary Medicine, 2025, 3
DOI: 10.1002/INMD.20250052

A Smart, Autocatalytic, DNAzyme Biocircuit for in Vivo, Amplified, MicroRNA Imaging

Jie Wei, Huimin Wang, Qiong Wu, Xue Gong, Kang Ma, Xiaoqing Liu and Fuan Wang

Angew Chem Int Ed, 2020, 59, 5965
DOI: 10.1002/anie.201911712

Enzyme-free isothermal amplification strategy for the detection of tumor-associated biomarkers: A review

Wenjia Wang, Qinyu Ge and Xiangwei Zhao

TrAC Trends in Analytical Chemistry, 2023, 160, 116960
DOI: 10.1016/j.trac.2023.116960