Issue 19, 2024

Chemistry, bioactivities, structure–activity relationship, biosynthesis and metabolism of prenylated flavonoids in Moraceae plants

Abstract

Plants from Moraceae are globally popular as they represent a valuable resource with wide applications in food, health-care products, and other fields. Prenylated flavonoids are important active components in Moraceae. These compounds share a flavonoid skeleton with prenylated side chain, mostly in the form of single or multiple isoprenyl substituents and benzodimethylfuran structures. So far, nearly 400 prenylated flavonoids have been found in Moraceae, especially a large number of Diels–Alder adducts, which are characteristic components of this family. Due to their distinctive structures, diverse pharmacological properties and interesting synthesis processes, these compounds have attracted considerable attention from scientists. Herein, we review the advances in the structural characteristics, bioactivities, structure–activity relationships, biosynthesis strategies and in vivo metabolism of prenylated flavonoids in Moraceae plants, aiming at strengthening research efforts and utilization toward the great untapped potential of these unique constituents in human health.

Graphical abstract: Chemistry, bioactivities, structure–activity relationship, biosynthesis and metabolism of prenylated flavonoids in Moraceae plants

Article information

Article type
Review Article
Submitted
06 6 2024
Accepted
19 8 2024
First published
22 8 2024

Food Funct., 2024,15, 9598-9631

Chemistry, bioactivities, structure–activity relationship, biosynthesis and metabolism of prenylated flavonoids in Moraceae plants

N. Li, W. Lu, H. Ren and Z. Chen, Food Funct., 2024, 15, 9598 DOI: 10.1039/D4FO02688H

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