Issue 66, 2024

Synthesis and application of chiral cis-2,5-disubstituted pyrrolidine organocatalysts

Abstract

The first synthesis of chiral cis-2,5-disubstituted pyrrolidine organocatalysts is described. Their application for the enantioselective Michael addition of nitromethane to α,β-unsaturated aldehydes with excellent yield (up to 91%) and enantioselectivity (up to >99% ee) is demonstrated. Another catalytic application for the reaction of 2,4-hexadienal with nitrostyrene is also showcased.

Graphical abstract: Synthesis and application of chiral cis-2,5-disubstituted pyrrolidine organocatalysts

Supplementary files

Article information

Article type
Communication
Submitted
27 6 2024
Accepted
23 7 2024
First published
23 7 2024

Chem. Commun., 2024,60, 8768-8771

Synthesis and application of chiral cis-2,5-disubstituted pyrrolidine organocatalysts

S. Singh, R. Kumar, N. N. Dubey and C. Appayee, Chem. Commun., 2024, 60, 8768 DOI: 10.1039/D4CC03132F

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