Issue 25, 2024

Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization

Abstract

The G-quartet-like supramolecular assembly present in guanosine hydrogel templates macrocyclization between bis-azide and bis-alkyne fragments. The resulting macrocycle enhances viscoelastic properties, and strengthens the hydrogel network. This approach holds potential for the in situ synthesis of drugs and their simultaneous delivery in a stimuli-responsive manner.

Graphical abstract: Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization

Supplementary files

Article information

Article type
Communication
Submitted
12 1 2024
Accepted
26 2 2024
First published
06 3 2024

Chem. Commun., 2024,60, 3433-3436

Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization

B. Lala, R. Chaudhuri, T. Prasanth, I. Burkhart, H. Schwalbe and J. Dash, Chem. Commun., 2024, 60, 3433 DOI: 10.1039/D4CC00129J

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