Issue 33, 2024

Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles

Abstract

The application of mRNA therapy is constrained by the current lipid nanoparticles' (LNPs) inability to target non-liver tissues. In this study, we demonstrate that ionizable lipids equipped with branched and biodegradable tails enhance the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells. This approach offers novel insights into how the chemical structure of LNPs influences their organ-specific targeting capabilities.

Graphical abstract: Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
05 5 2024
Accepted
22 7 2024
First published
23 7 2024

J. Mater. Chem. B, 2024,12, 8062-8066

Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles

Y. Ren, L. Zeng, Y. Tang, J. Liao, M. Jiang, X. Cao, H. Fan and J. Chen, J. Mater. Chem. B, 2024, 12, 8062 DOI: 10.1039/D4TB00960F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements