Decarboxylative arylation with diaryliodonium(iii) salts: alternative approach for catalyst-free difluoroenolate coupling to aryldifluoromethyl ketones

Abstract

Catalyst-free access to aryldifluoromethyl ketones has been achieved through decarboxylative arylation of α,α-difluoro-β-ketoacid salts using diaryliodonium(III) salts. The products were successfully transformed into the corresponding esters, amides, and difluoromethyl compounds. This strategy provides access to fluorine-containing drugs, thus contributing to drug design.