Issue 44, 2023

Ultra-selective 1D clean in-phase correlation spectroscopy

Abstract

Selective 1D COSY can unambiguously identify coupled spins but is often limited both by lack of selectivity, and by unfavourable multiplet lineshapes. Here, ultra-selective GEMSTONE excitation is employed with CLIP-COSY to provide through-bond correlations for nuclei whose NMR signals overlap. The new method is illustrated using the coccidiostat lasalocid and the immunosuppressant cyclosporin.

Graphical abstract: Ultra-selective 1D clean in-phase correlation spectroscopy

Supplementary files

Article information

Article type
Communication
Submitted
17 3 2023
Accepted
19 4 2023
First published
20 4 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 6734-6737

Ultra-selective 1D clean in-phase correlation spectroscopy

D. A. Taylor, P. Kiraly, P. Bowyer, M. Nilsson, L. Castañar, G. A. Morris and R. W. Adams, Chem. Commun., 2023, 59, 6734 DOI: 10.1039/D3CC01333B

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