Issue 9, 2022

Redox-neutral manganese-catalyzed synthesis of 1-pyrrolines

Abstract

This report describes a manganese-catalyzed radical [3 + 2] cyclization of cyclopropanols and oxime ethers, leading to valuable multi-functional 1-pyrrolines. In this redox-neutral process, the oxime ethers function as internal oxidants and H-donors. The reaction involves sequential rupture of C–C, C–H and N–O bonds and proceeds under mild conditions. This intermolecular protocol provides an efficient approach for the synthesis of structurally diverse 1-pyrrolines.

Graphical abstract: Redox-neutral manganese-catalyzed synthesis of 1-pyrrolines

Supplementary files

Article information

Article type
Edge Article
Submitted
03 1 2022
Accepted
09 2 2022
First published
09 2 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2022,13, 2669-2673

Redox-neutral manganese-catalyzed synthesis of 1-pyrrolines

T. Feng, C. Liu, Z. Wu, X. Wu and C. Zhu, Chem. Sci., 2022, 13, 2669 DOI: 10.1039/D2SC00015F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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