Issue 3, 2021

Recent progress of aggregation-induced emission luminogens (AIEgens) for bacterial detection and theranostics

Abstract

Bacterial infections have become one of the greatest threats to human health. The emergence of drug-resistant bacteria poses an urgent need to avoid bacterial resistance and sterilize bacteria. The fluorescence technology for the detection and image-guided therapy has attracted considerable attention. However, traditional fluorescent dyes suffering from aggregation-caused quenching are not suitable for biomedical applications. Aggregation-induced emission luminogens (AIEgens) that display strong emission in aggregated states, low background, high signal-to-noise ratio and sensitivity, and high resistance to photobleaching, may circumvent this problem. On the other hand, the overuse of anti-bacterial antibiotics diminishes their effect. It is imperative to develop novel antimicrobial approaches that could effectively avoid bacterial resistance. The development of AIEgens for bacterial detection and theranostics has recently caused a lot of concern, which is ascribed to their remarkable advantage compared with traditional organic fluorescent probes. The application of AIEgens in bacterial detection and treatment in the past five years was reviewed in this paper, including advancements in the development of versatile AIEgens for bacteria imaging, detection, and potential clinic therapy.

Graphical abstract: Recent progress of aggregation-induced emission luminogens (AIEgens) for bacterial detection and theranostics

Article information

Article type
Review Article
Submitted
27 9 2020
Accepted
28 10 2020
First published
30 10 2020

Mater. Chem. Front., 2021,5, 1164-1184

Recent progress of aggregation-induced emission luminogens (AIEgens) for bacterial detection and theranostics

X. Feng, B. Tong, J. Shi, C. Zhao, Z. Cai and Y. Dong, Mater. Chem. Front., 2021, 5, 1164 DOI: 10.1039/D0QM00753F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements