Issue 18, 2021

Harnessing lipid nanoparticles for efficient CRISPR delivery

Abstract

The CRISPR-Cas system has revolutionized the biomedical research field with its simple and flexible genome editing method. In October 2020, Emmanuelle Charpentier and Jennifer A. Doudna were awarded the 2020 Nobel Prize in chemistry in recognition of their outstanding contributions to the discovery of CRISPR-Cas9 genetic scissors, which allow scientists to alter DNA sequences with high precision. Recently, the first phase I clinical trials in cancer patients affirmed the safety and feasibility of ex vivo CRISPR-edited T cells. However, specific and effective CRISPR delivery in vivo remains challenging due to the multiple extracellular and intracellular barriers. Here, we discuss the recent advances in novel lipid nanomaterials for CRISPR delivery and describe relevant examples of potential therapeutics in cancers, genetic disorders, and infectious diseases.

Graphical abstract: Harnessing lipid nanoparticles for efficient CRISPR delivery

Article information

Article type
Minireview
Submitted
05 4 2021
Accepted
25 5 2021
First published
11 6 2021

Biomater. Sci., 2021,9, 6001-6011

Harnessing lipid nanoparticles for efficient CRISPR delivery

J. Yan, D. D. Kang and Y. Dong, Biomater. Sci., 2021, 9, 6001 DOI: 10.1039/D1BM00537E

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