Issue 20, 2020
From the journal:

Nanoscale

A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery†

Deyao Zhao,‡ac   Ge Yang,‡a   Qing Liu,ab   Wenjing Liu,ab   Yuhua Weng,a   Yi Zhao,a   Feng Qu,a   Lele Li ORCID logo b  and  Yuanyu Huang ORCID logo *a  

* Corresponding authors

a Advanced Research Institute of Multidisciplinary Science; School of Life Science; Institute of Engineering Medicine, Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing 100081, China
E-mail: yyhuang@bit.edu.cn

b CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China

c Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Erqi, Zhengzhou 450000, China

Abstract

A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.

Graphical abstract: A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

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Article information

DOI
https://doi.org/10.1039/D0NR00301H
Article type
Communication
Submitted
10 1 2020
Accepted
28 2 2020
First published
02 3 2020

Nanoscale, 2020,12, 10939-10943

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A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

D. Zhao, G. Yang, Q. Liu, W. Liu, Y. Weng, Y. Zhao, F. Qu, L. Li and Y. Huang, Nanoscale, 2020, 12, 10939 DOI: 10.1039/D0NR00301H

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