A fluorogenic probe for tracking GSH flux in developing neurons

Haichao Zong; Jiayi Peng; Xiao-Rong Li; Meng Liu; Yongzhou Hu; Jia Li; Yi Zang; Xin Li; Tony D. James

doi:10.1039/C9CC07753G

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A fluorogenic probe for tracking GSH flux in developing neurons†

Haichao Zong,‡^ab Jiayi Peng,‡^c Xiao-Rong Li,^c Meng Liu,^ab Yongzhou Hu,

^c Jia Li,^ab Yi Zang,*^ab Xin Li

*^c and Tony D. James

Author affiliations

* Corresponding authors

^a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: yzang@simm.ac.cn

^b University of Chinese Academy of Sciences, Beijing 100049, China

^c College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
E-mail: lixin81@zju.edu.cn

^d Department of Chemistry, University of Bath, Bath, UK

Abstract

Understanding GSH flux in developing neurons is prerequisite to reveal its role in neuronal development but necessiates an ultrasensitive assay. By systematically exploring key structural factors determing probe sensitivity in live cells, we developed a fluorogenic probe capable of imaging subtle GSH fluctuations in developing neurons.

This article is part of the themed collection: The Mechanics of Supramolecular Chemistry

Download options Please wait...

Supplementary files

Supplementary information PDF (1331K)

Article information

DOI: https://doi.org/10.1039/C9CC07753G
Article type: Communication
Submitted: 02 10 2019
Accepted: 27 11 2019
First published: 27 11 2019
This article is Open Access

Download Citation

Chem. Commun., 2020,56, 515-518

Permissions

Request permissions

A fluorogenic probe for tracking GSH flux in developing neurons

H. Zong, J. Peng, X. Li, M. Liu, Y. Hu, J. Li, Y. Zang, X. Li and T. D. James, Chem. Commun., 2020, 56, 515 DOI: 10.1039/C9CC07753G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

A fluorogenic probe for tracking GSH flux in developing neurons†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A fluorogenic probe for tracking GSH flux in developing neurons

Social activity

Search articles by author

Spotlight

Advertisements