Issue 34, 2019

Three-component vicinal-diarylation of alkenes via direct transmetalation of arylboronic acids

Abstract

Herein, we report three-component vicinal-diarylation of non-conjugated alkenes initiated by transmetalation of arylboronic acids, which provides complementary access to β,γ-diaryl carbonyl compounds. We have also screened a large number of chiral ligands for developing an enantioselective version of this reaction and obtained the preliminary results (up to 79 : 21 e.r.). Notably, the methodology developed herein represents the first three component syn-vicinal-dicarbofunctionalization of non-conjugated alkenes involving palladium catalysis.

Graphical abstract: Three-component vicinal-diarylation of alkenes via direct transmetalation of arylboronic acids

Supplementary files

Article information

Article type
Edge Article
Submitted
05 5 2019
Accepted
03 7 2019
First published
03 7 2019
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2019,10, 7952-7957

Three-component vicinal-diarylation of alkenes via direct transmetalation of arylboronic acids

Y. Zhang, G. Chen and D. Zhao, Chem. Sci., 2019, 10, 7952 DOI: 10.1039/C9SC02182E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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