Issue 27, 2019
From the journal:

Chemical Communications

Versatile fluorescence detection of microRNA based on novel DNA hydrogel-amplified signal probes coupled with DNA walker amplification†

Chunli Li,a   Hongkun Li,a   Junjun Gea  and  Guifen Jie ORCID logo *a  

* Corresponding authors

a Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
E-mail: guifenjie@126.com

Abstract

A novel DNA hydrogel-amplified versatile fluorescence platform combined with hybridization chain reaction (HCR) and DNA walking multiple amplification was developed for ultrasensitive detection of miRNA. The DNA hydrogel was loaded with large amounts of SYBR Green (SG) I dyes or CdTe quantum dots (QDs) to assemble versatile signal probes.

Graphical abstract: Versatile fluorescence detection of microRNA based on novel DNA hydrogel-amplified signal probes coupled with DNA walker amplification

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Article information

DOI
https://doi.org/10.1039/C9CC00565J
Article type
Communication
Submitted
22 1 2019
Accepted
06 3 2019
First published
14 3 2019

Chem. Commun., 2019,55, 3919-3922

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Versatile fluorescence detection of microRNA based on novel DNA hydrogel-amplified signal probes coupled with DNA walker amplification

C. Li, H. Li, J. Ge and G. Jie, Chem. Commun., 2019, 55, 3919 DOI: 10.1039/C9CC00565J

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