Issue 38, 2016
From the journal:

RSC Advances

Diselenide-based probe for the selective imaging of hypochlorite in living cancer cells†

Youngsam Kim,ab   Minsuk Choi,c   Sudesh T. Manjare,d   Sangyong Jonc  and  David G. Churchill*ab  

* Corresponding authors

a Molecular Logic Gate Laboratory, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon, Republic of Korea
E-mail: dchurchill@kaist.ac.kr

b Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), 373-1 Guseong-dong, Yuseong-gu, Daejeon, Republic of Korea

c Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon, Republic of Korea

d Department of Chemistry, University of Mumbai, Vidyanagari, Santacruz (E), Mumbai 400098, India

Abstract

A non-traditional and robust probe skeleton was derivatized for chemosensing applications to investigate a potential novel mode of hypochlorite detection. The BDPP-DSe probe gave a ∼180-fold “turn-on” response to hypochlorite. Confocal fluorescence imaging demonstrated detection of hypochlorite in living cells and cell membrane permeability.

Graphical abstract: Diselenide-based probe for the selective imaging of hypochlorite in living cancer cells

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Article information

DOI
https://doi.org/10.1039/C6RA04257K
Article type
Communication
Submitted
17 2 2016
Accepted
22 3 2016
First published
24 3 2016

RSC Adv., 2016,6, 32013-32017

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Diselenide-based probe for the selective imaging of hypochlorite in living cancer cells

Y. Kim, M. Choi, S. T. Manjare, S. Jon and D. G. Churchill, RSC Adv., 2016, 6, 32013 DOI: 10.1039/C6RA04257K

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