Issue 46, 2016

Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

Abstract

A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.

Graphical abstract: Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

Supplementary files

Article information

Article type
Communication
Submitted
01 2 2016
Accepted
01 4 2016
First published
06 4 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 7372-7375

Author version available

Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

L. H. Thomas, C. Wales and C. C. Wilson, Chem. Commun., 2016, 52, 7372 DOI: 10.1039/C6CC01027J

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