Issue 29, 2015
From the journal:

Chemical Communications

Fluorescent sensing of monofunctional platinum species†

Clara Shen,a   Benjamin D. W. Harris,b   Lucy J. Dawson,a   Kellie A. Charles,b   Trevor W. Hambleya  and  Elizabeth J. New*a  

* Corresponding authors

a School of Chemistry, The University of Sydney, Building F11, Australia
E-mail: elizabeth.new@sydney.edu.au
Tel: +61-2-9351-1993

b Department of Pharmacology, School of Medical Sciences, The University of Sydney, Building D06, Australia

Abstract

We report here FDCPt1, a novel selective fluorescent sensor for monofunctional platinum species. In the presence of such species, FDCPt1 exhibits a 70-fold increase in fluorescence emission, and can be used to monitor the metabolism of Pt(II)-based complexes in colorectal cancer cells. This probe is therefore expected to be valuable in studying changes in Pt coordination and distribution during chemotherapy.

Graphical abstract: Fluorescent sensing of monofunctional platinum species

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Article information

DOI
https://doi.org/10.1039/C4CC08077G
Article type
Communication
Submitted
13 10 2014
Accepted
04 3 2015
First published
11 3 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 6312-6314

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Fluorescent sensing of monofunctional platinum species

C. Shen, B. D. W. Harris, L. J. Dawson, K. A. Charles, T. W. Hambley and E. J. New, Chem. Commun., 2015, 51, 6312 DOI: 10.1039/C4CC08077G

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