Issue 21, 2014

Magnetic nanoparticle clusters as actuators of ssDNA release

Abstract

One of the major areas of research in nanomedicine is the design of drug delivery systems with remotely controllable release of the drug. Despite the enormous progress in the field, this aspect still poses a challenge, especially in terms of selectivity and possible harmful interactions with biological components other than the target. We report an innovative approach for the controlled release of DNA, based on clusters of core–shell magnetic nanoparticles. The primary nanoparticles are functionalized with a single-stranded oligonucleotide, whose pairing with a half-complementary strand in solution induces clusterization. The application of a low frequency (6 KHz) alternating magnetic field induces DNA melting with the release of the single strand that induces clusterization. The possibility of steering and localizing the magnetic nanoparticles, and magnetically actuating the DNA release discloses new perspectives in the field of nucleic-acid based therapy.

Graphical abstract: Magnetic nanoparticle clusters as actuators of ssDNA release

Supplementary files

Article information

Article type
Paper
Submitted
27 12 2013
Accepted
21 1 2014
First published
21 1 2014

Phys. Chem. Chem. Phys., 2014,16, 10023-10031

Magnetic nanoparticle clusters as actuators of ssDNA release

M. Banchelli, S. Nappini, C. Montis, M. Bonini, P. Canton, D. Berti and P. Baglioni, Phys. Chem. Chem. Phys., 2014, 16, 10023 DOI: 10.1039/C3CP55470H

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