Issue 30, 2012
From the journal:

Organic & Biomolecular Chemistry

Amphiphilic α-helix mimetics based on a benzoylurea scaffold†‡

Sam Thompsona  and  Andrew D. Hamilton*a  

* Corresponding authors

a Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK
E-mail: andrew.hamilton@chem.ox.ac.uk
Tel: +44 (0)1865 270242

Abstract

The design and synthesis of amphiphilic benzoylurea α-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an α-helix.

Graphical abstract: Amphiphilic α-helix mimetics based on a benzoylurea scaffold

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Article information

DOI
https://doi.org/10.1039/C2OB25273B
Article type
Communication
Submitted
06 2 2012
Accepted
19 3 2012
First published
25 4 2012

Org. Biomol. Chem., 2012,10, 5780-5782

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Amphiphilic α-helix mimetics based on a benzoylurea scaffold

S. Thompson and A. D. Hamilton, Org. Biomol. Chem., 2012, 10, 5780 DOI: 10.1039/C2OB25273B

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