Issue 30, 2012
From the journal:

Organic & Biomolecular Chemistry

Water-soluble, deep-red fluorescent squaraine rotaxanes†‡

Erin L. Cole,a   Easwaran Arunkumar,b   Shuzhang Xiao,a   Bryan A. Smitha  and  Bradley D. Smith*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA
E-mail: smith.115@nd.edu

b Molecular Targeting Technologies Incorporated, 833 Lincoln Ave., Unit 9, West Chester, PA, USA

Abstract

Eight fluorescent squaraine rotaxanes with deep-red absorption/emission wavelengths were prepared and assessed for chemical stability and suitability as water-soluble, fluorescent tracers. The most stable squaraine rotaxanes have four large stopper groups attached to the ends of the encapsulated squaraine, and two members of this structural class have promise as highly fluorescent tracers with rapid renal clearance and very low tissue uptake in living mice.

Graphical abstract: Water-soluble, deep-red fluorescent squaraine rotaxanes

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Article information

DOI
https://doi.org/10.1039/C2OB06783H
Article type
Communication
Submitted
23 10 2011
Accepted
22 11 2011
First published
22 11 2011

Org. Biomol. Chem., 2012,10, 5769-5773

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Water-soluble, deep-red fluorescent squaraine rotaxanes

E. L. Cole, E. Arunkumar, S. Xiao, B. A. Smith and B. D. Smith, Org. Biomol. Chem., 2012, 10, 5769 DOI: 10.1039/C2OB06783H

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