Issue 2, 2010
From the journal:

Chemical Communications

Silver(i)-mediated highly enantioselective synthesis of axially chiral allenes under thermal and microwave-assisted conditions†‡

Vanessa Kar-Yan Lo,a   Cong-Ying Zhou,a   Man-Kin Wong*b  and  Chi-Ming Che*a  

* Corresponding authors

a Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China
E-mail: cmche@hku.hk
Fax: +852-2857-1586
Tel: +852-2859-2154

b Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
E-mail: bcmkwong@inet.polyu.edu.hk
Fax: +852-2364-9932
Tel: +852-3400-8701

Abstract

Silver(I) salts mediated stereospecific transformation of optically active propargylamines to axially chiral allenes with excellent enantioselectivities (17 examples with 96–99% ee; one substrate with 91% ee) without subsequent racemization.

Graphical abstract: Silver(i)-mediated highly enantioselective synthesis of axially chiral allenes under thermal and microwave-assisted conditions

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Article information

DOI
https://doi.org/10.1039/B914516H
Article type
Communication
Submitted
20 7 2009
Accepted
04 9 2009
First published
16 9 2009

Chem. Commun., 2010,46, 213-215

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Silver(I)-mediated highly enantioselective synthesis of axially chiral allenes under thermal and microwave-assisted conditions

V. K. Lo, C. Zhou, M. Wong and C. Che, Chem. Commun., 2010, 46, 213 DOI: 10.1039/B914516H

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