Issue 30, 2012
From the journal:

Organic & Biomolecular Chemistry

Synthesis of a 3-deoxy-d-manno-octulosonic acid (KDO) building block from d-glucosevia fermentation†‡

Gulden Camci-Unal,a   Rahman M. Mizanur,a   Yonghai Chaia  and  Nicola L. B. Pohl*b  

* Corresponding authors

a Department of Chemistry, Iowa State University, Ames, IA, USA

b Wilkinson Professor of Interdisciplinary Engineering, Departments of Chemistry and of Chemical and Biological Engineering, and the Plant Sciences Institute, Hach Hall, Iowa State University, Ames, IA, USA
E-mail: npohl@iastate.edu
Fax: (+) 1-515-294-0105

Abstract

Herein we report the first synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block starting from glucose through pathway engineering of Escherichia coli and subsequent chemical modifications to provide an alternative method to produce KDO, found in plant and bacterial oligosaccharides.

Graphical abstract: Synthesis of a 3-deoxy-d-manno-octulosonic acid (KDO) building block from d-glucose via fermentation

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Article information

DOI
https://doi.org/10.1039/C2OB25168J
Article type
Paper
Submitted
20 1 2012
Accepted
08 3 2012
First published
16 4 2012

Org. Biomol. Chem., 2012,10, 5856-5860

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Synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block from D-glucose via fermentation

G. Camci-Unal, R. M. Mizanur, Y. Chai and N. L. B. Pohl, Org. Biomol. Chem., 2012, 10, 5856 DOI: 10.1039/C2OB25168J

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