Perspective
Reconceptualising mucoadhesion for future medicines
New perspectives on the design of mucoadhesive medicines highlight challenges with the current formulation approaches.
Review Article
Breaking the cellular delivery bottleneck: recent developments in direct cytosolic delivery of biologics
Proteins and nucleic acid therapeutics are delivered into cells via endosomal uptake/direct cytosolic entry. Endocytic pathways require endosomal escape, while direct fusion bypasses endosomes, enabling efficient delivery.
Communication
Reversibility of FUS-aided blood–tumor barrier opening for the delivery of therapeutics
In a dual-GBM mouse model, FUS was applied to selectively open the blood–tumor barrier in one tumor to assess 18F-avelumab and 18F-FDS penetration over 1–72 h, addressing whether FUS-induced barrier disruption is reversible.
Communication
Preliminary evidence for the combined efficacy of focused ultrasound blood–brain barrier opening and Re-1 delivery for anxiety and memory improvement in a 3xTg-Alzheimer's disease mouse model
This study explores Focused Ultrasound-mediated Blood–Brain Barrier Opening and Re-1 delivery in 3xTg-AD mice, showing improved long-term memory and reversal learning without affecting amyloid or tau pathology.
Communication
Sometimes less is more: avidity-dependent transport of targeted polymersomes across the blood–brain-barrier
Targeted PEG-b-PLA polymersomes safely transport anticancer drugs for glioblastoma treatment, with low ligand valency formulations showing superior blood–brain barrier (BBB) permeation compared to high-valency designs.
Paper
Predicting absorption of compounds from an in vivo liver surface based on molecular weight or in vitro release using a dialysis membrane in combination with lipophilicity
The combined influence of MW and log PC on compound absorption was investigated, and in-vitro in-vivo correlations were established to predict compound absorption from the murine liver surface, providing mechanistic insights into LSA absorption.
Paper
3D printing of tailored veterinary dual-release tablets: a semi-solid extrusion approach for metoclopramide
3D printable metoclopramide-containing ink formulation was developed for additive manufacturing of dual-release dosage forms suitable for tailored medicine to small animals.
Paper
On-demand release of encapsulated ZnO nanoparticles and chemotherapeutics for drug delivery applications
The results demonstrate the ability to induce the release of encapsulated ZnO nanoparticles and chemotherapeutics via photo-irradiation. Encapsulation minimizes cytotoxicity of encapsulated cargo but effectively combats cancerous cells upon release.
Paper
Electrospun dressings with a dual release functionality of two anti-inflammatory active ingredients
Development and in vitro as well as ex vivo characterization of different types polycaprolactone-based electrospun dressings containing the two anti-inflammatory active ingredients hydrocortisone and salicylic acid.
Paper
Biocompatible, injectable and self-healable MOF-based anti-freezing eutectogels for higher encapsulation and sustained release of the anticancer drug curcumin
A MOF based eutectogel with antibacterial and antioxidant attributes, along with hemocompatibility, is used for the encapsulation and sustained release of curcumin.