Themed collection US National Nanotechnology Day 2025


Electrified CO2 valorization in emerging nanotechnologies: a technical analysis of gas feedstock purity and nanomaterials in electrocatalytic and bio-electrocatalytic CO2 conversion
This perspective illuminates the crucial need to consider gas feedstock purity and source when designing new electrified CO2 conversion nanomaterials.
Environ. Sci.: Nano, 2024,11, 1770-1783
https://doi.org/10.1039/D3EN00912B
Bio-inspired carbon electrodes for metal-ion batteries
This mini-review highlights advances in multi-dimensional carbon electrodes with bio-inspired principles for metal-ion batteries.
Nanoscale, 2024,16, 5893-5902
https://doi.org/10.1039/D4NR00226A

Material characterization methods for investigating charge storage processes in 2D and layered materials-based batteries and supercapacitors
An overview of the characterization techniques for probing charge storage mechanisms of 2D and thin-layered materials as electrodes in electrochemical energy storage systems.
Nanoscale, 2025,17, 13531-13560
https://doi.org/10.1039/D5NR00649J

From synthesis to application: a review of BaZrS3 chalcogenide perovskites
This review covers BaZrS3 thin-film synthesis methods, optical, optoelectronic, electronic, and defect properties, and highlights device applications.
Nanoscale, 2025,17, 4250-4300
https://doi.org/10.1039/D4NR03880K

A comprehensive review of challenges and advances in exosome-based drug delivery systems
Key challenges in exosomal based therapies.
Nanoscale Adv., 2024,6, 5803-5826
https://doi.org/10.1039/D4NA00501E

Advancements in nanomaterials for nanosensors: a comprehensive review
Nanomaterials (NMs) exhibit unique properties that render them highly suitable for developing sensitive and selective nanosensors across various domains.
Nanoscale Adv., 2024,6, 4015-4046
https://doi.org/10.1039/D4NA00214H
Advances in lipid nanoparticle mRNA therapeutics beyond COVID-19 vaccines
This review highlights the latest advances in lipid nanoparticle mRNA based nanomedicines under preclinical and clinical investigation.
Nanoscale, 2024,16, 6820-6836
https://doi.org/10.1039/D4NR00019F
Employing nano-enabled artificial intelligence (AI)-based smart technologies for prediction, screening, and detection of cancer
AI enabled imaging technology advances the precision, early detection, and personalizes treatment through analysis and interpretation of medical images.
Nanoscale, 2024,16, 5458-5486
https://doi.org/10.1039/D3NR05648A

Recent advances in applications of MXenes for desalination, water purification and as an antibacterial: a review
Membranes have become a basis in tackling the global challenge of freshwater scarcity, notably in the fields of desalination and water purification.
Environ. Sci.: Nano, 2025,12, 1012-1036
https://doi.org/10.1039/D4EN00427B

A modular polymer platform for efficient mRNA delivery in cancer immunotherapy
A fluorinated PEI-based biopolymer assembled with mRNA and heparin enables efficient mRNA delivery with high transfection, robust antitumor efficacy, and cold-chain–free stability.
Nanoscale Horiz., 2025,10, 2550-2568
https://doi.org/10.1039/D5NH00299K

Multifunctional Ti3C2Tx-alginate foams for energy harvesting and fire warning
Ti3C2Tx is a versatile filler for biopolymer foams, introducing complementary functionalities like triboelectricity, thermal insulation and fire retardancy that can be exploited in energy and safety applications.
Nanoscale Horiz., 2025,10, 1084-1095
https://doi.org/10.1039/D5NH00049A

Molecular-scale in-operando reconfigurable electronic hardware
A dynamic molecular switch with 3 different functionalities makes it possible to reconfigure devices at molecular length scales and to access different memory states by simply changing the applied voltage.
Nanoscale Horiz., 2025,10, 349-358
https://doi.org/10.1039/D4NH00211C
Nanoscale-localized multiplexed biological activation of field effect transistors for biosensing applications
A paradigm shift in biofunctionalization of FETs for biosensors. Using thermal scanning probe lithography we achieve sub-20 nm spatially selective multiplexed functionalization, paving the way for massive parallel detection of multiple pathogens.
Nanoscale, 2024,16, 19620-19632
https://doi.org/10.1039/D4NR02535K
Green synthesis of iron-doped graphene quantum dots: an efficient nanozyme for glucose sensing
This study presents an effective approach for producing FeN/GQDs nanozymes, mimicking natural enzymes. With a simplified and eco-friendly method, it achieves remarkable peroxide-like activity and high sensitivity in glucose detection.
Nanoscale Horiz., 2024,9, 976-989
https://doi.org/10.1039/D4NH00024B

Magnetically driven lipid vesicles for directed motion and light-triggered cargo release
Systematic investigation of lipid vesicles propelled by encapsulated magnetic particles via an inhomogeneous magnetic field, enabling navigational control and remotely triggered drug release for targeted delivery and precision medicine applications.
Nanoscale, 2025,17, 13720-13726
https://doi.org/10.1039/D5NR00942A

Pushing the boundary of the stability and band gap Pareto front by going towards high-entropy perovskites
Medium/high-entropy vacancy-ordered double perovskites can push the boundary of the stability and band gap Pareto front, exhibiting emerging properties that are not present in their pure counterparts.
Nanoscale, 2025,17, 11376-11384
https://doi.org/10.1039/D4NR05013D

PEGylated lipid screening, composition optimization, and structure–activity relationship determination for lipid nanoparticle-mediated mRNA delivery
Screening PEG-lipids and optimizing lipid nanoparticle (LNP) composition for intramuscular mRNA delivery. Advanced characterization of LNPs elucidates the structure–activity relationship and identifies key LNP attributes for in vivo transfection.
Nanoscale, 2025,17, 11329-11344
https://doi.org/10.1039/D5NR00433K

Multimodal imaging approach to track theranostic nanoparticle accumulation in glioblastoma with magnetic resonance imaging and intravital microscopy
Magnetic resonance imaging and two-photon intravital microscopy metrics were correlated to track Ferumoxytol-based theranostic nanoparticles targeting glioblastoma multiforme in vivo at both macroscopic and microscopic levels.
Nanoscale, 2025,17, 9986-9995
https://doi.org/10.1039/D5NR00447K

Single-step, conformal, and efficient assembly of ligand-exchanged quantum dots for optoelectronic devices via an electric field
In this work the authors combined in-solution ligand exchange with an electrically driven film deposition technique to produce conformal PbSe quantum dot films on non-flat substrates in a single step without the need for post deposition processing.
Nanoscale, 2025,17, 8533-8543
https://doi.org/10.1039/D4NR04620J

Alternate InP synthesis with aminophosphines: solution–liquid–solid nanowire growth
Colloidal synthesis of InP nanowires is reported using aminophosphine and weakly-bound indium-ligand complexes, producing nanoribbons and nanowires. The aminophosphine is proposed to reduce indium for self-seeded solution–liquid–solid growth.
Nanoscale, 2025,17, 6593-6603
https://doi.org/10.1039/D4NR04907A

Eco-friendly synthesis of a porous reduced graphene oxide–polypyrrole–gold nanoparticle hybrid nanocomposite for electrochemical detection of methotrexate using a strip sensor
Chemotherapy is a crucial cancer treatment, but its effectiveness requires precise monitoring of drug concentrations in patients.
Nanoscale, 2025,17, 4472-4484
https://doi.org/10.1039/D4NR04010D

Polymer–iron oxide nanofiber composites for lead removal: performance improvements through organic acid stabilization of nanoparticles to promote surface segregation during electrospinning
Polymer–iron oxide nanofiber composites.
Environ. Sci.: Nano, 2025,12, 1487-1500
https://doi.org/10.1039/D4EN00902A

Multifunctional textured graphene-based coatings on elastomeric gloves for chemical protection
Wrinkled graphene coatings are engineered to fulfill multiple functions desired for ultrathin gloves that prevent human exposure to chemical toxicants.
Environ. Sci.: Nano, 2025,12, 433-449
https://doi.org/10.1039/D4EN00601A

Nanocarrier foliar uptake pathways affect delivery of active agents and plant physiological response
Top-side foliar application of layered double hydroxide penetrates the cuticle better, accumulates between epidermal cell walls, and improves plant performance more than bottom-side application.
Environ. Sci.: Nano, 2025,12, 660-674
https://doi.org/10.1039/D4EN00547C

Encapsulated mitochondria to reprogram the metabolism of M2-type macrophages for anti-tumor therapy
In this study, our innovative Mito@ZiF-8 system enhances the functionality of isolated mitochondria and reprograms M2 macrophage metabolism upon delivery, ultimately, reducing the tumorigenic potential of breast cancer cells.
Nanoscale, 2024,16, 20925-20939
https://doi.org/10.1039/D4NR02471K

Impact of morphology and oxygen vacancy content in Ni, Fe co-doped ceria for efficient electrocatalyst based water splitting
Schematic presentation of Ni + Fe co-doped CeO2 mesoporous.
Nanoscale Adv., 2024,6, 4672-4682
https://doi.org/10.1039/D4NA00500G

Iron oxide nanozymes enhanced by ascorbic acid for macrophage-based cancer therapy
This study reveals unique pH-dependent behaviors of IONPs and ascorbic acid, paving the way for a macrophage-based cell therapy.
Nanoscale, 2024,16, 14330-14338
https://doi.org/10.1039/D4NR01208A

A novel nanocomposite drug delivery system for SARS-CoV-2 infections
To develop an inhalable drug delivery system, we synthesized Remdesivir-loaded nanocomposites (RDV NCs) by coating drug-loaded nanoparticles with supramolecular cell-penetrating peptide nanofibers, enhancing uptake and intracellular drug delivery.
Nanoscale Adv., 2024,6, 3747-3758
https://doi.org/10.1039/D4NA00361F
Advanced dual-atom catalysts on graphitic carbon nitride for enhanced hydrogen evolution via water splitting
This study explores novel DACs for enhanced hydrogen evolution using DFT calculations, identifying materials with high electrochemical stability and low energy barriers, paving the way for advanced sustainable energy technologies.
Nanoscale, 2024,16, 13148-13160
https://doi.org/10.1039/D4NR01241K
Foliar application of iron-based nanofertilizers to wheat grown in a Cd-contaminated field: implications for food safety and biofortification
Nanotechnology applications in agriculture have received considerable attention with the aim of improving crop production, nutritional quality and food safety.
Environ. Sci.: Nano, 2024,11, 2577-2590
https://doi.org/10.1039/D3EN00958K
Multi-atomic loaded C2N1 catalysts for CO2 reduction to CO or formic acid
Triple-atom catalysts exhibit moderate adsorption energy for intermediate species, enabling the optimal performance of the CO2 electrocatalytic reduction reaction.
Nanoscale, 2024,16, 9791-9801
https://doi.org/10.1039/D4NR01082E

Proceeding of catalytic water splitting on Cu/Ce@g-C3N4 photocatalysts: an exceptional approach for sunlight-driven hydrogen generation
This study investigates the photocatalytic hydrogen evolution on Cu/Ce supported g-C3N4 catalyst.
Nanoscale, 2024,16, 7154-7166
https://doi.org/10.1039/D4NR00111G

Ultra-thin proton conducting carrier layers for scalable integration of atomically thin 2D materials with proton exchange polymers for next-generation PEMs
Scalable approaches for synthesis and integration of proton selective atomically thin 2D materials with proton conducting polymers can enable next-generation proton exchange membranes with minimal crossover while retaining adequate proton conductance.
Nanoscale, 2024,16, 6973-6983
https://doi.org/10.1039/D3NR05202H
Emerging electrospinning platform toward nanoparticle to single atom transformation for steering selectivity in ammonia synthesis
A “top down” strategy for the transformation of Co NPs to Co SAs was proposed and the synthesized Co SAs/CNF electrocatalyst exhibited excellent electrocatalytic NO3RR activity with a FE of 91.30% at −0.70 V vs. RHE.
Nanoscale, 2024,16, 4047-4055
https://doi.org/10.1039/D3NR05331H

Antimicrobial peptide-conjugated phage-mimicking nanoparticles exhibit potent bactericidal action against Streptococcus pyogenes in murine wound infection models
Modularly assembled, antimicrobial peptide capped phage-mimicking nanoparticles are highly biocompatible, rapidly bactericidal, and clear wound infections without the emergence of antibacterial resistance.
Nanoscale Adv., 2024,6, 1145-1162
https://doi.org/10.1039/D3NA00620D
Inducing preferential growth of the Zn (002) plane by using a multifunctional chelator for achieving highly reversible Zn anodes
We propose a multifunctional electrolyte additive, sodium gluconate (SG), which induces the growth of Zn (002) crystal plane by preferentially adsorbing on other crystal planes and thus inhibiting the growth of Zn dendrite.
Nanoscale, 2024,16, 2923-2930
https://doi.org/10.1039/D3NR05699F
About this collection
National Nanotechnology Day is an annual celebration in the US featuring a series of community-led events and activities on or around October 9 to help raise awareness of nanotechnology, how it is currently used in products that enrich our daily lives, and the challenges and opportunities it holds for the future. This date, 10/9, pays homage to the nanometer scale, 10–9 meters. More information is available here: https://www.nano.gov/nationalnanotechnologyday/
To celebrate, we have put together a series of top articles by US researchers published recently across Nanoscale Horizons, Nanoscale, Nanoscale Advances and Environmental Science: Nano. This cross-journal collection showcases how nanotechnology can be utilised in a diverse range of applications in healthcare, safety, electronics, energy, agriculture, the environment and more. We hope that you enjoy reading them!