Above, the open-state protein of SHP2(SHP2*) was constructed from SHP1, and the allosteric process of SHP2 was investigated by coarse-graining and NRI-MD modeling.
Src homology 2-domain-containing tyrosine phosphatase 2 (SHP2) is a non-receptor protein tyrosine phosphatase that is widely expressed in a variety of cells and regulates the immune response of T cells through the PD-1 pathway.
Here, we develop covalent inhibitors that inactivate protein tyrosine phosphatases (PTPs) via electrophilic modification of functional tyrosines.
We have determined the heterogeneous structural ensemble of the tandem SH2 domains of the protein tyrosine phosphatase SHP2 in agreement with experimental data from small-angle X-ray scattering and NMR residual dipolar couplings in solution.
Development of benzimidazole-based salicylic acid derivatives as novel fluorophores:Identification of the representative benzimidazole-based salicylic acid 5q with excellent SHP1 inhibition and obvious fluorescence specificity for Fe3+.