The transformation of carboxylic acids into acyl fluorides via triphosgene-mediated deoxyfluorination utilizing inexpensive potassium fluoride (KF) has been achieved.
This review highlights recent advances in the use of fluorinated reactive intermediates as an activation mode of carboxylic acids within synthetic organic chemistry. A range of their transformations are discussed.
We report the chemoselective copper-catalyzed acylsilylation of vinyl arenes using bench-stable silylboronates and acyl fluorides, which enables efficient access to β-silyl ketones under mild conditions.
2-Pyridinesulfonyl fluoride mediated deoxyfluorination of carboxylic acid to acyl fluoride, allowing one-pot amidation and esterification under mild conditions.
A direct deoxyfluorination of carboxylic acids by utilizing KF as fluoride source has been developed. Scale-up reaction could be carried out under the solvent-free conditions, which exhibited the practicability of this reaction in organic synthesis.