The transformation of carboxylic acids into acyl fluorides via triphosgene-mediated deoxyfluorination utilizing inexpensive potassium fluoride (KF) has been achieved.
We report the chemoselective copper-catalyzed acylsilylation of vinyl arenes using bench-stable silylboronates and acyl fluorides, which enables efficient access to β-silyl ketones under mild conditions.
A visible light mediated green process for the synthesis of carbamoyl/acyl fluorides followed by urea/amide formation for the modification of drugs and lysine-selective bioconjugation are demonstrated in a physiological buffer medium.
A direct deoxyfluorination of carboxylic acids by utilizing KF as fluoride source has been developed. Scale-up reaction could be carried out under the solvent-free conditions, which exhibited the practicability of this reaction in organic synthesis.
This review highlights recent advances in the use of fluorinated reactive intermediates as an activation mode of carboxylic acids within synthetic organic chemistry. A range of their transformations are discussed.