The transformation of carboxylic acids into acyl fluorides via triphosgene-mediated deoxyfluorination utilizing inexpensive potassium fluoride (KF) has been achieved.
This review highlights recent advances in the use of fluorinated reactive intermediates as an activation mode of carboxylic acids within synthetic organic chemistry. A range of their transformations are discussed.
We report the chemoselective copper-catalyzed acylsilylation of vinyl arenes using bench-stable silylboronates and acyl fluorides, which enables efficient access to β-silyl ketones under mild conditions.
Cyanodifluorosulfonium ion as an efficient deoxyfluorinating reagent has been developed to activate cinnamic acids selectively into vinyl acyl fluoride reaction intermediates.
2-Pyridinesulfonyl fluoride mediated deoxyfluorination of carboxylic acid to acyl fluoride, allowing one-pot amidation and esterification under mild conditions.