Expeditious entry into carbocyclic and heterocyclic spirooxindoles

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Org. Biomol. Chem., 2024, 22, 7817
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Stereoselective synthesis of 3,3′-spirooxindoles with higher order heterocycles

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Org. Biomol. Chem., 2025, 23, 8829
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Efficient construction of spirocyclopentane-1,3-dioxindoles via an annulation reaction of isocyanides and 3-methyleneoxindoles

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Org. Biomol. Chem., 2025, 23, 3224
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Diastereoselective assembly of dispiro-cyclopentene-linked bisoxindoles via annulation involving isatylidene malononitriles and benzylamines

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Diastereoselective aldol-type interception of phenolic oxonium ylides for the direct assembly of 2,2-disubstituted dihydrobenzofurans

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Stereoselective synthesis of CF3-containing spirocyclic-oxindoles using N-2,2,2-trifluoroethylisatin ketimines: an update

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Dithiocarbamation of spiro-aziridine oxindoles: a facile access to C3-functionalised 3-thiooxindoles as apoptosis inducing agents

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Atom-economic metal free mediated difunctionalization of isocyanides with 3-methyleneoxindoles and 3-methylene-benzofuranones

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[3+2]-Annulation of oxindolinyl-malononitriles with Morita–Baylis–Hillman acetates of nitroalkenes for the regio- and diastereoselective synthesis of spirocyclopentane-indolinones

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Tetrahedron, 2022, 108, 132650
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Enantioselective Synthesis of Spirocyclopentane Oxindoles Bearing Five Consecutive Stereocenters through Secondary Amine‐Catalyzed [3+2] Cycloaddition

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Eur J Org Chem, 2022, 2022
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Regioselective synthesis and in vitro cytotoxicity evaluation of 3-thiooxindole derivatives: Tubulin polymerization inhibition and apoptosis inducing studies

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Substrate-Controlled Regioselectivity Switchable [3 + 2] Annulations To Access Spirooxindole Skeletons

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J. Org. Chem., 2022, 87, 8158
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Design, Synthesis, and In Vitro and In Silico Anticancer Profiling of Spirooxindole–Tetrahydrocarbazoles

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ChemMedChem, 2026, 21
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Molecular Diversity of Base Promoted Annulation of MBH Carbonates of Isatins and Dialkyl But‐2‐ynedioates

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ChemistrySelect, 2023, 8
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Hydroxyl group modulated diastereoselective synthesis of functionalized spiro[indoline-3,3′-pyrrolidines]

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Journal of Molecular Structure, 2025, 1347, 143070
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DBU-Mediated Diastereoselective (3+2)-Cycloaddition of Isatin Ketonitrones and Coumarins to Construct Coumarin-Fused Spiropyrolidine Oxoindoles

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Metal-Free Regioselective Oxa-Michael Approach to Access Spirooxindole-Fused Tetrahydrofuran/Tetrahydropyran through [3 + 2]/ [4 + 2] Spirocyclization of Methyleneindolinones with Haloalcohols

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An Efficient Route to Access Spirooxindole–Pyrazolone-Fused Cyclopentenes by a Diastereoselective [3+2] Annulation

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Selective and Reversible 1,3-Dipolar Cycloaddition of 2-(2-Oxoindoline-3-ylidene)acetates with Nitrones in the Synthesis of Functionalized Spiroisoxazolidines

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Enantioselective Desymmetrization of Curcumins with 3‐Olefinic Oxindoles for the Synthesis of Spirocyclohexanoneoxindoles

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Eur J Org Chem, 2023, 26
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1,3-Dipolar Cycloaddition of Stable Azomethine Ylide Based on Ninhydrin and L-Proline to Phosphorylated Acetylenes

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Molecular diversity of the reactions of MBH carbonates of isatins and various nucleophiles

Zi-Ying Xiao, Jing Sun and Chao-Guo Yan

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Substrate‐Controlled Regioselectivity Switch in a Three‐Component 1,3‐Dipolar Cycloaddition Reaction to Access 3,3′‐Pyrrolidinyl‐Spirooxindoles Derivatives

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Synthesis and anti-Cancer Activity of a New Hybrid Based Spirooxindole-Pyrrolidine -Thiochromene Scaffolds via [3 + 2] Cycloaddition Reaction: Computational Investigation

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Organocatalytic Aza-Michael/Mannich Cascade Reaction: Synthesis of Enantioenriched 3,3′-Spirooxindole γ-Lactams

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J. Org. Chem., 2023, 88, 7839
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Construction of C2‐Spirocyclopropyl‐Indolin‐3‐Ones through Base‐Promoted [2+1] Annulation Reaction of Indolin‐3‐ones with Bromosulfonium Salts

Mao Zhang, Fenfen Yang, Xiang Guan, Mingshan Shuai, Qingqing Zhang, Xiaozhong Fu, Yuanyong Yang, Meng Zhou, Bin He and Yonglong Zhao

Eur J Org Chem, 2023, 26
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Organocatalytic Regio- and Enantioselective [3 + 2]-Annulations of Ninhydrin-Derived Morita–Baylis–Hillman Carbonates with 3-Methyleneoxindoles

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Base Promoted Three‐component Reaction for Efficient Construction of Spiro[indoline‐3,3′‐quinoline]‐2,5′‐dione

Ping Wu, Feng‐Shun Xu, Jing Sun and Chao‐Guo Yan

ChemistrySelect, 2023, 8
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Convenient Synthesis of Dihydrobenzofuran‐Fused Spirocyclopentane‐1,2‐Diindolinone Scaffolds

Ting Tang, Ying Han, Chao‐Guo Yan, Kun Huang and Jing Sun

Eur J Org Chem, 2024, 27
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N-Iodosuccinimide-Promoted Selective Construction of Cyclopropyl and Dihydrofuranyl Spirooxindoles from Alkylidene Oxindoles and Annular β-Dicarbonyl Compounds

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An Access to Highly Functionalized Dihydrobenzofuran Spirooxindole Scaffolds

Daqian Wang, Jing Sun, Ying Han, Qiu Sun and Chao-Guo Yan

Org. Lett., 2022, 24, 7790
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Recent update on the role of N-methyl glycine as a building block for the construction of N-heterocyclic frameworks

Madhu Ganesh

Tetrahedron, 2022, 127, 133096
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Convenient synthesis of chromene-fused spirocyclopentane-1,2-dioxindoles via base promoted annulation reaction

Kun Huang, Ting Tang, Ying Han, Jing Sun and Chao-Guo Yan

Tetrahedron Letters, 2025, 156, 155455
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Hydroazidation of phenacylideneoxindoles: Synthesis of 3-substituted 3-azido-1,3-dihydro-2H-indol-2-ones via anti-electron addition

Ailipire Aisikaer, Jing Ma, Jiajia Li and Xiaojuan Li

Tetrahedron Letters, 2023, 120, 154447
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Synthesis of Semaxanib-like 3-alkylideneoxindoles and their binding investigation with ctDNA by multiple methods

Xiao-Yun Li, Ruo-Hui Gao, Jie Zhu, Xiao-Hong Yang, Yu-Jie Wang, Yu-Han Jiang and Xue-Chao Wang

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Visible-light-promoted [3 + 2] cycloaddition for the synthesis of spirooxindoles under external photocatalyst-free conditions

Bin Wang, Yang Shao, Ziren Chen, Fei Xue, Yonghong Zhang, Yu Xia, Weiwei Jin, Shaofeng Wu and Chenjiang Liu

Journal of Molecular Structure, 2025, 1322, 140434
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Asymmetric α-Regioselective [3 + 2] Annulation of Morita–Baylis–Hillman Carbonates: Construction of Three Contiguous Stereocenters with Vicinal Quaternary Carbon Centers

Xiaochen Tian, Yongxing Zhang, Hao Dong, Weiwu Ren and Yang Wang

J. Org. Chem., 2022, 87, 9593
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Stereoselective Synthesis of Highly Functionalized Aminobenzothiazole-Fused Spirooxindole Derivatives: in silico and in vitro Anti-Diabetic Studies

Narayanasamy Nivetha, Shashank M. Patil, Ramith Ramu, Swamy Sreenivasa and Sivan Velmathi

Synthesis, 2023, 55, 4145
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Rapid construction of S-containing spirooxindoles and dispirooxindoles via annulation of MBH maleimides of isatins

Kun Huang, Kai-Hua Zhang, Zi-Ying Xiao, Ying Han, Jing Sun and Chao-Guo Yan

Tetrahedron Letters, 2025, 156, 155452
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Convenient Synthetic Protocols for Diverse Functionalized Dihydrobenzofuran-Fused Spiro-indanedione-oxindole Scaffolds

Jing Sun, Xueyan Liu, Qiu Sun, Ying Han and Chao-Guo Yan

J. Org. Chem., 2023, 88, 11562
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Synthesis of Dispirocyclic Compounds via (3 + 2) Annulation of Morita–Baylis–Hillman Maleimides of Isatins With 2‐Arylideneindane‐1,3‐Diones

Kai‐Kai Wang, Bo‐Wen Zhang, Liang‐Man Wu, Xue‐Hao Wang, Xue Xue, Peng Lu, Cheng‐Shi Chen, Guo‐Yi Yan and Rongxiang Chen

Journal of Heterocyclic Chem, 2025, 62, 2030
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Recent advances in palladium-catalyzed cyclizations for the synthesis of spirooxindoles

Yue Wang, Jiehui Niu, Lingli Bu, Er-Qing Li and Teck-Peng Loh

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Cascade Reaction of 3-Phenacylideneoxindoles with Trimethylsilyl Cyanide: Synthesis of Furan-Fused 1,3-Benzodiazepin-2-one Derivatives

Jing Ma, Shao-Yi Li, Ailipire Aisikaer and Xiao-Juan Li

Synlett, 2022, 33, 559
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1,3-dipolar cycloaddition of stable azomethine ylide based on ninhydrin and l-proline to phosphorylated acetylenes

A. A Sokolov, D. M Egorov, Yu. A. Pronina, S. M Ramsh and A. V Stepakov

Žurnal obŝej himii, 2023, 93, 1050
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Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction

Ziying Xiao, Fengshun Xu, Jing Sun and Chao-Guo Yan

Beilstein J. Org. Chem., 2023, 19, 1234
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A Regioselective Multicomponent Approach for the Synthesis of Novel 2‐Acetyl‐4‐phenylquinoline Designed Monospiro‐Pyrrolidine and Thiapyrrolizidine Hybrids

Satheeshkumar Rajendran, Arul Murugesan, Shankar Ramasamy and Wangbin Wu

Heteroatom Chemistry, 2025, 2025
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Asymmetric Synthesis of Strained Multichiral Spirocyclobutanes through Cage-Confined Cross [2 + 2] Photocycloaddition

Jia Ruan, Yu-Lin Lu, Peng Hu and Cheng-Yong Su

J. Am. Chem. Soc., 2025, 147, 10475
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Construction of diazepine-containing spiroindolines via annulation reaction of α-halogenated N-acylhydrazones and isatin-derived MBH carbonates

Xing Liu, Wenjing Shi, Jing Sun and Chao-Guo Yan

Beilstein J. Org. Chem., 2023, 19, 1923
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Synthesis for polycyclic spirooxindoles via base promoted spiroannulation reaction of cyclic β-enaminones and MBH maleimides of isatins

Shao-Cong Zhan, Zi-Ying Xiao, Jing Sun and Chao-Guo Yan

Tetrahedron Letters, 2025, 168, 155720
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