An integrated platform for metamaterial-based sensing and surface acoustic wave-based acoustofluidics utilising circular interdigital transducers

Shahrzad Zahertar, Hamdi Torun, Ran Tao, Pep Canyelles-Pericas, Jingting Luo, Qiang Wu and Yong-Qing Fu

Sens. Diagn., 2022, 1, 270
DOI: 10.1039/D1SD00050K

Vibration technology-based droplet microfluidic devices for biomedical applications

Peng Yin, Yanna Lin, Maojie Jiang, Xiangyu Jiang, Xuan Fang, Mengjie Huang, Baihui Zhang and Fuqiang Ma

Sens. Diagn., 2026, 5, 270
DOI: 10.1039/D5SD00163C

Surface acoustic wave manipulation of bioparticles

Meili Qi, Dan Dang, Xieliu Yang, Junhai Wang, Hemin Zhang and Wenfeng Liang

Soft Matter, 2023, 19, 4166
DOI: 10.1039/D3SM00457K

Ultrasound-Responsive Systems as Components for Smart Materials

Athanasios G. Athanassiadis, Zhichao Ma, Nicolas Moreno-Gomez, Kai Melde, Eunjin Choi, Rahul Goyal and Peer Fischer

Chem. Rev., 2022, 122, 5165
DOI: 10.1021/acs.chemrev.1c00622

Towards Portable MEMS Oscillators for Sensing Nanoparticles

Malar Chellasivalingam, Arthur T. Zielinski, Thomas S. Whitney, Adam M. Boies and Ashwin A. Seshia

Sensors, 2022, 22, 5485
DOI: 10.3390/s22155485

Acousto‐Photolithography for Programmable Shape Deformation of Composite Hydrogel Sheets

Minghao Li, Jiyang Mei, James Friend and Jinhye Bae

Small, 2022, 18
DOI: 10.1002/smll.202204288

Numerical study of thermocapillary and slip effects on interfacial destabilization under surface acoustic waves

Jia Ning, Qing-Yun Huang, Chen-Hui Gai, Yi-Zhan Ding, Bing Zhang, Yu-Lin Lei, Yang Wu and Hong Hu

Physics of Fluids, 2024, 36
DOI: 10.1063/5.0215087

Acoustic micro‐beam vortex generator for flow actuation inside droplets

Diego Sánchez‐Saldaña, Maria Fernandino and Carlos A. Dorao

Droplet, 2024, 3
DOI: 10.1002/dro2.96

A plug-and-play surface acoustic wave-based SERS chip for rapid enrichment and ultrasensitive detection of tumor exosomes

Tingyu Wang, Zefan Xu, Lei Wu, Yu Zhang, Hang Liu, Zuyao Wang, Shenfei Zong, Kuo Yang, Hong Wang and Zhuyuan Wang

Microchim Acta, 2026, 193
DOI: 10.1007/s00604-026-07974-z

Soret effect on interfacial instability of droplet driven by surface acoustic waves

Jialu Wang, Nailin Ma, Xin Chu, Quansheng Liu and Yongjun Jian

Physics of Fluids, 2025, 37
DOI: 10.1063/5.0281850

A novel detachable acoustofluidic device for microparticle separation via tilted standing waves modulated by micro-holography

Luming Li, Mingyong Zhou, Lei Huang, Linghan Shen, Zhigao Ma and Bingyan Jiang

Separation and Purification Technology, 2025, 379, 134872
DOI: 10.1016/j.seppur.2025.134872

Rapid microparticle separation based on acoustofluidic particle manipulation inside a sessile droplet

Meijin Du, Shaoshuai Han, Yangyang Yu, He Li, Di Lian, Honghao Li, Xin Yang, Tangcheng Huang, Jun Ren and Zhenlin Wu

Sensors and Actuators A: Physical, 2025, 395, 116959
DOI: 10.1016/j.sna.2025.116959

Extracellular vesicle-based point-of-care testing for diagnosis and monitoring of Alzheimer’s disease

Xiang Li, Jie Chen, Yang Yang, Hongwei Cai, Zheng Ao, Yantao Xing, Kangle Li, Kaiyuan Yang, Weihua Guan, James Friend, Luke P. Lee, Nian Wang and Feng Guo

Microsyst Nanoeng, 2025, 11
DOI: 10.1038/s41378-025-00916-4

Assessment of silicon, glass, FR4, PDMS and PMMA as a chip material for acoustic particle/cell manipulation in microfluidics

Hande N. Açıkgöz, Alara Karaman, M. Akif Şahin, Ömer R. Çaylan, Göknur C. Büke, Ender Yıldırım, İrem C. Eroğlu, A. Elif Erson-Bensan, Barbaros Çetin and M. Bülent Özer

Ultrasonics, 2023, 129, 106911
DOI: 10.1016/j.ultras.2022.106911

Aerosol jet printing of surface acoustic wave microfluidic devices

Joseph Rich, Brian Cole, Teng Li, Brandon Lu, Hanyu Fu, Brittany N. Smith, Jianping Xia, Shujie Yang, Ruoyu Zhong, James L. Doherty, Kanji Kaneko, Hiroaki Suzuki, Zhenhua Tian, Aaron D. Franklin and Tony Jun Huang

Microsyst Nanoeng, 2024, 10
DOI: 10.1038/s41378-023-00606-z

Skipping the Boundary Layer: High-Speed Droplet-Based Immunoassay Using Rayleigh Acoustic Streaming

Qi Wang, Zhe Ding, Gary Wong, Jia Zhou and Antoine Riaud

Anal. Chem., 2023, 95, 6253
DOI: 10.1021/acs.analchem.2c03877

On-chip centrifuge using spiral surface acoustic waves on a ZnO/glass substrate

Junjie Huang, Zhihao Zhu, Yu Zhang, Juan Tu, Xiasheng Guo and Dong Zhang

Sensors and Actuators A: Physical, 2022, 347, 113901
DOI: 10.1016/j.sna.2022.113901

Acoustic-assisted centrifugal microfluidics for particle/cell separation

Soroush Zaheri-Ghannad, Vahid Kordzadeh-Kermani and Masoud Madadelahi

Chemical Engineering and Processing - Process Intensification, 2024, 201, 109803
DOI: 10.1016/j.cep.2024.109803

Surface Acoustic Wave Devices: New Mechanisms, Enabling Techniques, and Application Frontiers

Hongsheng Xu, Xiangyu Liu, Weihao Ye, Xiangyu Zeng, Akeel Qadir and Jinkai Chen

Micromachines, 2026, 17, 494
DOI: 10.3390/mi17040494

Acoustofluidic Tweezers Integrated with Droplet Sensing Enable Multifunctional Closed‐Loop Droplet Manipulation

Mingyang Sui, Huijuan Dong, Guanyu Mu, Zhen Yang, Ye Ai and Jie Zhao

Advanced Science, 2025, 12
DOI: 10.1002/advs.202409394

Acoustofluidics for biomedical applications

Joseph Rufo, Feiyan Cai, James Friend, Martin Wiklund and Tony Jun Huang

Nat Rev Methods Primers, 2022, 2
DOI: 10.1038/s43586-022-00109-7

Acoustofluidic-based therapeutic apheresis system

Mengxi Wu, Zhiteng Ma, Xianchen Xu, Brandon Lu, Yuyang Gu, Janghoon Yoon, Jianping Xia, Zhehan Ma, Neil Upreti, Imran J. Anwar, Stuart J. Knechtle, Eileen T. Chambers, Jean Kwun, Luke P. Lee and Tony Jun Huang

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-50053-1

A thin film-mediated omnidirectional spiral surface acoustic waves in combination with porous hydrogel microparticles for rapid immuno-biosensing

Chun-Jui Chen, Wei-Hsiang Chou, Jae-Sung Kwon and Han-Sheng Chuang

Biosensors and Bioelectronics, 2026, 307, 118752
DOI: 10.1016/j.bios.2026.118752

Synergistic effect of acoustic streaming and nanozymes on enhanced intracellular dopamine detection

Feng Zhu, Xinyang Hu, Xiaoyu Wu, Die Xu, Quanning Li, Xuejiao Chen, Wei Pang, Xuexin Duan, Yanyan Wang and Mingxia He

Biosensors and Bioelectronics, 2025, 280, 117431
DOI: 10.1016/j.bios.2025.117431

Droplet acoustofluidics: Recent progress and challenges

Mushtaq Ali, Woohyuk Kim, Muhammad Soban Khan, Mehmet Akif Sahin, Ghulam Destgeer and Jinsoo Park

Biomicrofluidics, 2025, 19
DOI: 10.1063/5.0261531

Micro-centrifuge: Controlling coffee ring effect with surface acoustic waves on a patterned substrate

Taehong Kim and Arezoo M. Ardekani

Journal of Colloid and Interface Science, 2026, 703, 139142
DOI: 10.1016/j.jcis.2025.139142

Dual‐Wave Acoustofluidic Centrifuge for Ultrafast Concentration of Nanoparticles and Extracellular Vesicles

Povilas Dumčius, Roman Mikhaylov, Xiaoyan Zhang, Matthew Bareford, Mercedes Stringer, Rachel Errington, Chao Sun, Esperanza Gonzalez, Tomaš Krukovski, Juan M Falcon‐Perez, Dongfang Liang, Yong‐Qing Fu, Aled Clayton and Xin Yang

Small, 2023, 19
DOI: 10.1002/smll.202300390

A Review of Research Progress in Microfluidic Bioseparation and Bioassay

Heng Zhao, Yanyan Zhang and Dengxin Hua

Micromachines, 2024, 15, 893
DOI: 10.3390/mi15070893

Acoustofluidic dynamic interfacial tensiometry

Umar Farooq, Yuanting Liu, Pengqi Li, Zhiting Deng, Xiufang Liu, Wei Zhou, Shasha Yi, Ning Rong, Long Meng, Lili Niu and Hairong Zheng

The Journal of the Acoustical Society of America, 2021, 150, 3608
DOI: 10.1121/10.0007161

Acoustic tweezers for advancing precision biology and medicine

Shujie Yang, Joseph Rufo, Ying Chen, Chuyi Chen, Bruce W. Drinkwater, Luke P. Lee and Tony Jun Huang

Nat Rev Methods Primers, 2025, 5
DOI: 10.1038/s43586-025-00415-w

Review of micro/nanofluidic particle separation mechanisms: Toward combined multiple physical fields for nanoparticles

Kyunghun Lee, Rahul Mishra and Taesung Kim

Sensors and Actuators A: Physical, 2023, 363, 114688
DOI: 10.1016/j.sna.2023.114688

Odd viscosity effect on interfacial instability of droplet on a heated substrate driven by surface acoustic waves

Jialu Wang, Xin Chu, Quansheng Liu and Yongjun Jian

Physics of Fluids, 2025, 37
DOI: 10.1063/5.0294237

Unapodization: a method to produce laterally uniform surface acoustic waves for acoustofluidics

Naiqing Zhang, Amihai Horesh, Cécile Floer and James Friend

J. Micromech. Microeng., 2021, 31, 104001
DOI: 10.1088/1361-6439/ac1d2d

Monolithic Acoustic Droplet Centrifuge Array for Enhancing Point‐of‐Care Detection of Trace MicroRNAs

Jingui Qian, Chuanmin Liu, Jingjing He, Xiaojin Liu, Shaohui Zheng, Jing Liu, Minghui Chen, Yong‐Qing Fu and Longzhen Qiu

Small, 2026, 22
DOI: 10.1002/smll.202509713

Recent advances and challenges of manipulation of micro- and nanoparticles by surface acoustic wave in microfluidics

Wenbo Han, Zhihang Fu, Zhiwei Xu, Hongyuan Zou, Haoyu Yue, Wei Li and Hongpeng Zhang

Chaos, Solitons & Fractals, 2026, 208, 118063
DOI: 10.1016/j.chaos.2026.118063

Optofluidic sorting of microparticles using Airy beams

Zhelin Qu, Kunpeng Wang, Chao Feng, Tianli Wu, Yao Zhang, Xian Zhao and Jun-Lei Wang

International Journal of Optomechatronics, 2024, 18
DOI: 10.1080/15599612.2024.2375538

Modeling fast acoustic streaming: Steady-state and transient flow solutions

Jeremy Orosco and James Friend

Phys. Rev. E, 2022, 106
DOI: 10.1103/PhysRevE.106.045101

Surface Acoustic Wave-Driven Enhancement of Enzyme-Linked Immunosorbent Assays: ELISAW

Lei Zhang, Shuai Zhang, Cécile Floer, Sreeya Anjana Raj Kantubuktha, María José González Ruiz Velasco and James Friend

Anal. Chem., 2024, 96, 9676
DOI: 10.1021/acs.analchem.4c01615

Microscale acoustic streaming for biomedical and bioanalytical applications

Wei Wei, Yaping Wang, Zhaoxun Wang and Xuexin Duan

TrAC Trends in Analytical Chemistry, 2023, 160, 116958
DOI: 10.1016/j.trac.2023.116958

Methodologies, technologies, and strategies for acoustic streaming-based acoustofluidics

Mercedes Stringer, Ziming Zeng, Xiaoyan Zhang, Yanyan Chai, Wen Li, Jikai Zhang, Huiling Ong, Dongfang Liang, Jing Dong, Yiming Li, Yongqing Fu and Xin Yang

Applied Physics Reviews, 2023, 10
DOI: 10.1063/5.0134646

Sonoporation: Past, Present, and Future

Joseph Rich, Zhenhua Tian and Tony Jun Huang

Adv Materials Technologies, 2022, 7
DOI: 10.1002/admt.202100885

Acoustofluidics

James Friend

Front. Acoust., 2023, 1
DOI: 10.3389/facou.2023.1261027

Fluid–structure boundary-driven simultaneous standard-inverse Chladni patterns for selective particles manipulation

Zewei Hou, Yongmao Pei, Duo Xu, Bo Yu and Yuyang Lin

Physics of Fluids, 2025, 37
DOI: 10.1063/5.0249974

Rapid Enrichment of Submicron Particles within a Spinning Droplet Driven by a Unidirectional Acoustic Transducer

Tao Peng, Cui Fan, Mingyong Zhou, Fengze Jiang, Dietmar Drummer and Bingyan Jiang

Anal. Chem., 2021, 93, 13293
DOI: 10.1021/acs.analchem.1c02914

Fully Microfabricated Surface Acoustic Wave Tweezer for Collection of Submicron Particles and Human Blood Cells

Armaghan Fakhfouri, Melanie Colditz, Citsabehsan Devendran, Kateryna Ivanova, Stefan Jacob, Adrian Neild and Andreas Winkler

ACS Appl. Mater. Interfaces, 2023, 15, 24023
DOI: 10.1021/acsami.3c00537

Acoustic separation and concentration of exosomes for nucleotide detection: ASCENDx

Ty D. Naquin, Aidan J. Canning, Yuyang Gu, Jianing Chen, Chloe M. Naquin, Jianping Xia, Brandon Lu, Shujie Yang, Aleksandra Koroza, Katherine Lin, Hsin-Neng Wang, William R. Jeck, Luke P. Lee, Tuan Vo-Dinh and Tony Jun Huang

Sci. Adv., 2024, 10
DOI: 10.1126/sciadv.adm8597

Solutal Marangoni effect and chemical reactions on interfacial instability of droplet driven by surface acoustic waves

Jialu Wang, Xin Chu, Quansheng Liu and Yongjun Jian

Physics of Fluids, 2025, 37
DOI: 10.1063/5.0272851

Microfluidic methods for cell separation and subsequent analysis

Tianyou Chen, Chunxia Huang, Yanran Wang and Jing Wu

Chinese Chemical Letters, 2022, 33, 1180
DOI: 10.1016/j.cclet.2021.07.067

Design of interdigitated transducers for acoustofluidic applications

Shuren Song, Qi Wang, Jia Zhou and Antoine Riaud

Nanotechnology and Precision Engineering, 2022, 5
DOI: 10.1063/10.0013405

Asymmetrically aligned focused acoustic waves for enhancing sensing performance of electrochemical microarrays

Tengfei Zheng, Yue Liu, Yongqing Fu and Chaohui Wang

Applied Physics Letters, 2023, 122
DOI: 10.1063/5.0147389

Piezoelectric MEMS—evolution from sensing technology to diversified applications in the 5G/Internet of Things (IoT) era

Xianhao Le, Qiongfeng Shi, Philippe Vachon, Eldwin J. Ng and Chengkuo Lee

J. Micromech. Microeng., 2022, 32, 014005
DOI: 10.1088/1361-6439/ac3ab9

Particles separation using the inverse Chladni pattern enhanced local Brazil nut effect

Zewei Hou, Zhitao Zhou, Zengyao Lv and Yongmao Pei

Extreme Mechanics Letters, 2021, 49, 101466
DOI: 10.1016/j.eml.2021.101466

On-chip phased interdigital metamaterials enable versatile manipulation of surface acoustic waves, microfluids, and micro/nano-objects

Jiali Li, Luyu Bo, Teng Li, Liang Shen, Chongpeng Qiu, Yingshan Du, Shujie Yang and Zhenhua Tian

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-66488-z

Effect of viscosity on surface acoustic wave driven collective particle dynamics in sessile droplets: Cloud, cavities, and aggregates

Shuren Song, Jia Zhou and Antoine Riaud

Physics of Fluids, 2022, 34
DOI: 10.1063/5.0097354

A Comprehensive Review of Surface Acoustic Wave-Enabled Acoustic Droplet Ejection Technology and Its Applications

Jia Ning, Yulin Lei, Hong Hu and Chenhui Gai

Micromachines, 2023, 14, 1543
DOI: 10.3390/mi14081543

Acoustomicrofluidic Concentration and Signal Enhancement of Fluorescent Nanodiamond Sensors

Asma Akther, Ella P. Walsh, Philipp Reineck, Brant C. Gibson, Takeshi Ohshima, Hiroshi Abe, Gawain McColl, Nicole L. Jenkins, Liam T. Hall, David A. Simpson, Amgad R. Rezk and Leslie Y. Yeo

Anal. Chem., 2021, 93, 16133
DOI: 10.1021/acs.analchem.1c03893

Wireless Frequency‐Multiplexed Acoustic Array‐Based Acoustofluidics

Jiali Li, Luyu Bo, Teng Li, Penghui Zhao, Yingshan Du, Bowen Cai, Liang Shen, Wujin Sun, Wei Zhou and Zhenhua Tian

Adv Materials Technologies, 2024, 9
DOI: 10.1002/admt.202400572

Manipulating acoustic streaming in a droplet using a single surface acoustic wave transducer

Bingjin Jue, Kaining Wen, Tengfei Zheng, Yupei Qiao, Guangbin Zhang and Xiaofeng Zhang

Applied Acoustics, 2025, 231, 110517
DOI: 10.1016/j.apacoust.2024.110517

Analysis of nanoparticle enrichment process by considering deformation of droplet in acoustic microfluidic system

Lei Huang, Mingyong Zhou, Luming Li, Tao Peng and Binyan Jiang

Sensors and Actuators A: Physical, 2023, 363, 114731
DOI: 10.1016/j.sna.2023.114731

Concentration of Microparticles/Cells Based on an Ultra-Fast Centrifuge Virtual Tunnel Driven by a Novel Lamb Wave Resonator Array

Wei Wei, Zhaoxun Wang, Bingnan Wang, Wei Pang, Qingrui Yang and Xuexin Duan

Biosensors, 2024, 14, 280
DOI: 10.3390/bios14060280