Recent progress on radiofluorination using metals: strategies for generation of C–18F bonds

Truong Giang Luu and Hee-Kwon Kim

Org. Chem. Front., 2023, 10, 5746
DOI: 10.1039/D3QO00772C

Radiosynthesis of [18F]brequinar for in vivo PET imaging of hDHODH for potential studies of acute myeloid leukemia and cancers

Vinay Kumar Banka, Stefano Sainas, Elena Martino, Jiacheng Wang, Marco Lucio Lolli and Yu-Shin Ding

RSC Med. Chem., 2024, 15, 3147
DOI: 10.1039/D4MD00433G

Preparation of labeled aromatic amino acids via late-stage 18F-fluorination of chiral nickel and copper complexes

Austin Craig, Niklas Kolks, Elizaveta A. Urusova, Johannes Zischler, Melanie Brugger, Heike Endepols, Bernd Neumaier and Boris D. Zlatopolskiy

Chem. Commun., 2020, 56, 9505
DOI: 10.1039/D0CC02223C

Scalable 18F processing conditions for copper-mediated radiofluorination chemistry facilitate DoE optimization studies and afford an improved synthesis of [18F]olaparib

Gregory D. Bowden, Nantanat Chailanggar, Bernd J. Pichler and Andreas Maurer

Org. Biomol. Chem., 2021, 19, 6995
DOI: 10.1039/D1OB00903F

Radiofluorination of non-activated aromatic prosthetic groups for synthesis and evaluation of fluorine-18 labelled ghrelin(1–8) analogues

Marina D. Childs, Lihai Yu, Michael S. Kovacs and Leonard G. Luyt

Org. Biomol. Chem., 2021, 19, 8812
DOI: 10.1039/D1OB01023A

Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging

Rocío García-Vázquez, Umberto M. Battisti, Jesper T. Jørgensen, Vladimir Shalgunov, Lars Hvass, Daniel L. Stares, Ida N. Petersen, François Crestey, Andreas Löffler, Dennis Svatunek, Jesper L. Kristensen, Hannes Mikula, Andreas Kjaer and Matthias M. Herth

Chem. Sci., 2021, 12, 11668
DOI: 10.1039/D1SC02789A

Copper-catalyzed/mediated borylation reactions of epoxides with diboron reagents: access to β-hydroxyl boronic esters

Ebrahim-Alkhalil M. A. Ahmed, Xi Lu, Tian-Jun Gong, Zhen-Qi Zhang, Bin Xiao and Yao Fu

Chem. Commun., 2017, 53, 909
DOI: 10.1039/C6CC07924E

18F-labelling of nitrogen-containing aryl boronates – anti-cancer drug melflufen as a case study

Kevin Bajerke, Fredrik Lehmann, Gunnar Antoni and Kálmán J. Szabó

Org. Chem. Front., 2024, 11, 6411
DOI: 10.1039/D4QO01594K

Nucleophilic radiosynthesis of boron neutron capture therapy-oriented PET probe [18F]FBPA using aryldiboron precursors

Jing He, Heng Yan, Yanrong Du, Yan Ji, Fei Cai, Wenbin Fan, Li Huo, Yuan-Hao Liu, Zheng Wang and Shihong Li

Chem. Commun., 2021, 57, 8953
DOI: 10.1039/D1CC03369G

Fluorination of organoboron compounds

Graham Pattison

Org. Biomol. Chem., 2019, 17, 5651
DOI: 10.1039/C9OB00832B

[11C]Cyanation of arylboronic acids in aqueous solutions

Longle Ma, Michael S. Placzek, Jacob M. Hooker, Neil Vasdev and Steven H. Liang

Chem. Commun., 2017, 53, 6597
DOI: 10.1039/C7CC02886E

Proof-of-concept optimization of a copper-mediated 18F-radiosynthesis of a novel MAGL PET tracer on a high-throughput microdroplet platform and its macroscale translation

Yingqing Lu, Yingfang He, Roger Schibli, Linjing Mu and R. Michael van Dam

Lab Chip, 2023, 23, 4652
DOI: 10.1039/D3LC00735A

Boron reagents for divergent radiochemistry

Thomas C. Wilson, Thomas Cailly and Véronique Gouverneur

Chem. Soc. Rev., 2018, 47, 6990
DOI: 10.1039/C8CS00499D

One-pot synthesis of high molar activity 6-[18F]fluoro-l-DOPA by Cu-mediated fluorination of a BPin precursor

Andrew V. Mossine, Sean S. Tanzey, Allen F. Brooks, Katarina J. Makaravage, Naoko Ichiishi, Jason M. Miller, Bradford D. Henderson, Marc B. Skaddan, Melanie S. Sanford and Peter J. H. Scott

Org. Biomol. Chem., 2019, 17, 8701
DOI: 10.1039/C9OB01758E

18F-Fluoroform: a 18F-trifluoromethylating agent for the synthesis of SCF218F-aromatic derivatives

Elodie Carbonnel, Tatiana Besset, Thomas Poisson, Daniel Labar, Xavier Pannecoucke and Philippe Jubault

Chem. Commun., 2017, 53, 5706
DOI: 10.1039/C7CC02652H

A concise method for fully automated radiosyntheses of [18F]JNJ-46356479 and [18F]FITM via Cu-mediated 18F-fluorination of organoboranes

Gengyang Yuan, Timothy M. Shoup, Sung-Hyun Moon and Anna-Liisa Brownell

RSC Adv., 2020, 10, 25223
DOI: 10.1039/D0RA04943C

Radiosynthesis of SPECT tracers via a copper mediated123I iodination of (hetero)aryl boron reagents

Thomas C. Wilson, Greg McSweeney, Sean Preshlock, Stefan Verhoog, Matthew Tredwell, Thomas Cailly and Véronique Gouverneur

Chem. Commun., 2016, 52, 13277
DOI: 10.1039/C6CC07417K

Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor

Achi Haider, Irina Iten, Hazem Ahmed, Adrienne Müller Herde, Stefan Gruber, Stefanie D. Krämer, Claudia Keller, Roger Schibli, Bernhard Wünsch, Linjing Mu and Simon M. Ametamey

J Nucl Med, 2019, 60, 259
DOI: 10.2967/jnumed.118.212134

Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF

Katarina J. Makaravage, Allen F. Brooks, Andrew V. Mossine, Melanie S. Sanford and Peter J. H. Scott

Org. Lett., 2016, 18, 5440
DOI: 10.1021/acs.orglett.6b02911

Automation of Copper-Mediated 18F-Fluorination of Aryl Pinacol Boronates Using 4-Dimethylaminopyridinium Triflate

Mikhail A. Nadporojskii, Viktoriya V. Orlovskaya, Olga S. Fedorova, Dmitry S. Sysoev and Raisa N. Krasikova

Molecules, 2024, 29, 3342
DOI: 10.3390/molecules29143342

Radiolabeled (4-Fluoro-3-Iodobenzyl)Guanidine Improves Imaging and Targeted Radionuclide Therapy of Norepinephrine Transporter–Expressing Tumors

Aiko Yamaguchi, Hirofumi Hanaoka, Tetsuya Higuchi and Yoshito Tsushima

J Nucl Med, 2018, 59, 815
DOI: 10.2967/jnumed.117.201525

Effective Preparation of [18F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor

Mohammad B. Haskali, Peter D. Roselt, Terence J. O’Brien, Craig A. Hutton, Idrish Ali, Lucy Vivash and Bianca Jupp

Molecules, 2022, 27, 5931
DOI: 10.3390/molecules27185931

Concise and Scalable Radiosynthesis of (+)-[18F]MDL100907 as a Serotonin 5-HT2A Receptor Antagonist for PET

Lahu N. Chavan, Ronald Voll, Mar M. Sanchez, Jonathon A. Nye and Mark M. Goodman

ACS Chem. Neurosci., 2023, 14, 3694
DOI: 10.1021/acschemneuro.3c00382

(Radio)fluoroclick Reaction Enabled by a Hydrogen‐Bonding Cluster

Xiaojun Zeng, Junling Li, Chin K. Ng, Gerald B. Hammond and Bo Xu

Angewandte Chemie, 2018, 130, 2974
DOI: 10.1002/ange.201711341

A Practical Method for the Preparation of 18F-Labeled Aromatic Amino Acids from Nucleophilic [18F]Fluoride and Stannyl Precursors for Electrophilic Radiohalogenation

Fadi Zarrad, Boris Zlatopolskiy, Philipp Krapf, Johannes Zischler and Bernd Neumaier

Molecules, 2017, 22, 2231
DOI: 10.3390/molecules22122231

Fluorine-18 Patents (2009–2015). Part 2: New Radiochemistry

Andrew V Mossine, Stephen Thompson, Allen F Brooks, Alexandra R Sowa, Jason M Miller and Peter JH Scott

Pharm. Pat. Anal., 2016, 5, 319
DOI: 10.4155/ppa-2016-0028

Cu-Mediated C–H 18F-Fluorination of Electron-Rich (Hetero)arenes

Matthew S. McCammant, Stephen Thompson, Allen F. Brooks, Shane W. Krska, Peter J. H. Scott and Melanie S. Sanford

Org. Lett., 2017, 19, 3939
DOI: 10.1021/acs.orglett.7b01902

Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions

Xiaoyun Deng, Jian Rong, Lu Wang, Neil Vasdev, Lei Zhang, Lee Josephson and Steven H. Liang

Angew Chem Int Ed, 2019, 58, 2580
DOI: 10.1002/anie.201805501

Automated synthesis of PET radiotracers by copper‐mediated 18F‐fluorination of organoborons: Importance of the order of addition and competing protodeborylation

Andrew V. Mossine, Allen F. Brooks, Vadim Bernard‐Gauthier, Justin J. Bailey, Naoko Ichiishi, Ralf Schirrmacher, Melanie S. Sanford and Peter J.H. Scott

Labelled Comp Radiopharmac, 2018, 61, 228
DOI: 10.1002/jlcr.3583

Copper-mediated radiochemistry: historical impact, current trends, and future possibilities

Gregory D. Bowden, Marius Müller, Matthias M. Herth, Melanie S. Sanford and Peter J. H. Scott

npj Imaging, 2025, 3
DOI: 10.1038/s44303-025-00087-x

11C- and 18F-Radiotracers for In Vivo Imaging of the Dopamine System: Past, Present and Future

Michael R. Kilbourn

Biomedicines, 2021, 9, 108
DOI: 10.3390/biomedicines9020108

Baeyer‐Villiger oxidation tuned to chemoselective conversion of non‐activated [18F]fluorobenzaldehydes to [18F]fluorophenols

Johannes Ermert, Johnny Castillo Meleán, Swen Humpert, Daniel Modemann, Dominik Krupp, Isabel Kern, Sabrina Kreft and Heinz H. Coenen

Labelled Comp Radiopharmac, 2019, 62, 380
DOI: 10.1002/jlcr.3740

MCR Scaffolds Get Hotter with 18F-Labeling

Tryfon Zarganes-Tzitzikas, Gonçalo S. Clemente, Philip H. Elsinga and Alexander Dömling

Molecules, 2019, 24, 1327
DOI: 10.3390/molecules24071327

Suppressing Protodeboronation in Cu‐Mediated 19F/18F‐Fluorination of Arylboronic Acids: A Mechanistically Guided Approach Towards Optimized PET Probe Development

Jingkai Sun, Carolin Jaworski, Ralf Schirrmacher and Dennis G. Hall

Chemistry A European J, 2024
DOI: 10.1002/chem.202400906

18F-Deoxyfluorination of Phenols via Ru π-Complexes

Hudson Beyzavi, Debashis Mandal, Martin G. Strebl, Constanze N. Neumann, Erica M. D’Amato, Junting Chen, Jacob M. Hooker and Tobias Ritter

ACS Cent. Sci., 2017, 3, 944
DOI: 10.1021/acscentsci.7b00195

Controlled Single and Double Iodofluorination of Alkynes with DIH- and HF-Based Reagents

Lukas Pfeifer and Véronique Gouverneur

Org. Lett., 2018, 20, 1576
DOI: 10.1021/acs.orglett.8b00321

Conversion of iodine to fluorine-18 based on iodinated chalcone and evaluation for β-amyloid PET imaging

Sho Kaide, Masahiro Ono, Hiroyuki Watanabe, Yoichi Shimizu, Yuji Nakamoto, Kaori Togashi, Aiko Yamaguchi, Hirofumi Hanaoka and Hideo Saji

Bioorganic & Medicinal Chemistry, 2018, 26, 3352
DOI: 10.1016/j.bmc.2018.05.001

(Radio)Fluorination Reactions for the Synthesis of Aryl Fluorides: Recent Advances and Perspectives

Jie Han and Zhan‐Ming Zhang

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400502

Cobalt-Catalyzed C–F Bond Borylation of Aryl Fluorides

Soobin Lim, Dalnim Song, Seungwon Jeon, Youngsuk Kim, Hyunseok Kim, Sanghee Lee, Hyungdo Cho, Byung Chul Lee, Sang Eun Kim, Kimoon Kim and Eunsung Lee

Org. Lett., 2018, 20, 7249
DOI: 10.1021/acs.orglett.8b03167

Microwave‐Assisted Rapid One‐Pot Synthesis of Fused and Non‐Fused Indoles and 5‐[18F]Fluoroindoles from Phenylazocarboxylates

Jasmin Krüll, Anja Hubert, Natascha Nebel, Olaf Prante and Markus R. Heinrich

Chemistry A European J, 2017, 23, 16174
DOI: 10.1002/chem.201703890

Iridium‐katalysierte C‐H‐Borylierung von Heteroarenen: Eine Balance zwischen sterischer and elektronischer Regiokontrolle

Jay S. Wright, Peter J. H. Scott and Patrick G. Steel

Angewandte Chemie, 2021, 133, 2830
DOI: 10.1002/ange.202001520

Phase Transfer Catalysts and Role of Reaction Environment in Nucleophilc Radiofluorinations in Automated Synthesizers

Raisa N. Krasikova and Viktoriya V. Orlovskaya

Applied Sciences, 2021, 12, 321
DOI: 10.3390/app12010321

Sequential Ir/Cu-Mediated Method for the Meta-Selective C–H Radiofluorination of (Hetero)Arenes

Jay S. Wright, Liam S. Sharninghausen, Sean Preshlock, Allen F. Brooks, Melanie S. Sanford and Peter J. H. Scott

J. Am. Chem. Soc., 2021, 143, 6915
DOI: 10.1021/jacs.1c00523

Spirocyclic Iodonium Ylides for Fluorine‐18 Radiolabeling of Non‐Activated Arenes: From Concept to Clinical Research

Melissa Chassé, Anna Pees, Anton Lindberg, Steven H. Liang and Neil Vasdev

The Chemical Record, 2023, 23
DOI: 10.1002/tcr.202300072

Gold(I)-Mediated Radioiododecarboxylation of Arenes

Hugo Bloux, Ahmed Ait Khouya, Jana Sopkova-de Oliveira Santos, Frédéric Fabis, Emmanuelle Dubost and Thomas Cailly

Org. Lett., 2023, 25, 8100
DOI: 10.1021/acs.orglett.3c03191

[18F]DAA1106: Automated radiosynthesis using spirocyclic iodonium ylide and preclinical evaluation for positron emission tomography imaging of translocator protein (18 kDa)

Katsushi Kumata, Yiding Zhang, Masayuki Fujinaga, Takayuki Ohkubo, Wakana Mori, Tomoteru Yamasaki, Masayuki Hanyu, Lin Xie, Akiko Hatori and Ming-Rong Zhang

Bioorganic & Medicinal Chemistry, 2018, 26, 4817
DOI: 10.1016/j.bmc.2018.08.017

Synthesis of [18F]Fluoroarenes by Nucleophilic Radiofluorination of N‐Arylsydnones

Maruthi Kumar Narayanam, Gaoyuan Ma, Pier Alexandre Champagne, Kendall N. Houk and Jennifer M. Murphy

Angewandte Chemie, 2017, 129, 13186
DOI: 10.1002/ange.201707274

Radiosynthesis and Preclinical Evaluation of an 18F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A)

Barbara Wenzel, Stefan R. Fritzsche, Magali Toussaint, Detlef Briel, Klaus Kopka, Peter Brust, Matthias Scheunemann and Winnie Deuther-Conrad

Pharmaceuticals, 2022, 15, 1272
DOI: 10.3390/ph15101272

Rationalizing the Binding Modes of PET Radiotracers Targeting the Norepinephrine Transporter

Anna Tutov, Xinyu Chen, Rudolf A. Werner, Saskia Mühlig, Thomas Zimmermann, Naoko Nose, Kazuhiro Koshino, Constantin Lapa, Michael Decker and Takahiro Higuchi

Pharmaceutics, 2023, 15, 690
DOI: 10.3390/pharmaceutics15020690

18F-Labelled catecholamine type radiopharmaceuticals in the diagnosis of neurodegenerative diseases and neuroendocrine tumours: approaches to synthesis and development prospects

Sergey Z. Vatsadze, Olga E. Eremina, Irina A. Veselova, Stepan N. Kalmykov and Valentin G. Nenajdenko

Russ. Chem. Rev., 2018, 87, 350
DOI: 10.1070/RCR4752

Radiolabelled Peptides: Optimal Candidates for Theranostic Application in Oncology

Andrew J. Hall and Mohammad B. Haskali

Aust. J. Chem., 2021, 75, 34
DOI: 10.1071/CH21118

Chemie der Positronenemissionstomographie: Aktuelle Fortschritte bei 11C‐, 18F‐, 13N‐ und 15O‐Markierungsreaktionen

Xiaoyun Deng, Jian Rong, Lu Wang, Neil Vasdev, Lei Zhang, Lee Josephson and Steven H. Liang

Angewandte Chemie, 2019, 131, 2604
DOI: 10.1002/ange.201805501

Alcohol-Supported Cu-Mediated 18F-Fluorination of Iodonium Salts under “Minimalist” Conditions

Victoriya V. Orlovskaya, Daniel J. Modemann, Olga F. Kuznetsova, Olga S. Fedorova, Elizaveta A. Urusova, Niklas Kolks, Bernd Neumaier, Raisa N. Krasikova and Boris D. Zlatopolskiy

Molecules, 2019, 24, 3197
DOI: 10.3390/molecules24173197

Production of 6-l-[18F]Fluoro-m-tyrosine in an Automated Synthesis Module for 11C-Labeling

Viktoriya V. Orlovskaya, Austin S. Craig, Olga S. Fedorova, Olga F. Kuznetsova, Bernd Neumaier, Raisa N. Krasikova and Boris D. Zlatopolskiy

Molecules, 2021, 26, 5550
DOI: 10.3390/molecules26185550

Structure–Affinity Relationships of 2,3,4,5-Tetrahydro-1H-3-benzazepine and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-amine Analogues and the Discovery of a Radiofluorinated 2,3,4,5-Tetrahydro-1H-3-benzazepine Congener for Imaging GluN2B Subunit-Containing N-Methyl-d-aspartate Receptors

Hazem Ahmed, Achi Haider, Jasmine Varisco, Maja Stanković, Rahel Wallimann, Stefan Gruber, Irina Iten, Surya Häne, Adrienne Müller Herde, Claudia Keller, Roger Schibli, Dirk Schepmann, Linjing Mu, Bernhard Wünsch and Simon M. Ametamey

J. Med. Chem., 2019, 62, 9450
DOI: 10.1021/acs.jmedchem.9b00812

PET Imaging of PARP Expression Using 18F-Olaparib

Thomas C. Wilson, Mary-Ann Xavier, James Knight, Stefan Verhoog, Julia Baguña Torres, Michael Mosley, Samantha L. Hopkins, Sheena Wallington, Phillip D. Allen, Veerle Kersemans, Rebekka Hueting, Sean Smart, Véronique Gouverneur and Bart Cornelissen

J Nucl Med, 2019, 60, 504
DOI: 10.2967/jnumed.118.213223

18F-labelling innovations and their potential for clinical application

Heinz H. Coenen and Johannes Ermert

Clin Transl Imaging, 2018, 6, 169
DOI: 10.1007/s40336-018-0280-0

Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin

Gonçalo S. Clemente, Tryfon Zarganes-Tzitzikas, Alexander Dömling and Philip H. Elsinga

Molecules, 2019, 24, 4210
DOI: 10.3390/molecules24234210

A General Protocol for Cu-Mediated Fluoro-deamination: Sandmeyer Fluorination of Diverse Aromatic Substrates

R. Manuel Pérez-García, Gaute Grønnevik and Patrick J. Riss

Org. Lett., 2021, 23, 1011
DOI: 10.1021/acs.orglett.0c04209

Recent advances in transition metal-mediated/ catalyzed radiofluorination of arenes and heteroarenes for positron emission tomography

Haiyan Chen, Buchuan Zhang, Siyu Chen, Feng Xiong, Xiaohua Zhu, Bo Yu and Sihui Long

Bioorganic Chemistry, 2025, 157, 108272
DOI: 10.1016/j.bioorg.2025.108272

Molecular Design and Synthetic Strategy toward Development of PET Probes

Takashi Niwa and Takamitsu Hosoya

J. Synth. Org. Chem. Jpn., 2024, 82, 433
DOI: 10.5059/yukigoseikyokaishi.82.433

NHC-Copper Mediated Ligand-Directed Radiofluorination of Aryl Halides

Liam S. Sharninghausen, Allen F. Brooks, Wade P. Winton, Katarina J. Makaravage, Peter J. H. Scott and Melanie S. Sanford

J. Am. Chem. Soc., 2020, 142, 7362
DOI: 10.1021/jacs.0c02637

Preclinical Development of18F-OF-NB1 for Imaging GluN2B-ContainingN-Methyl-d-Aspartate Receptors and Its Utility as a Biomarker for Amyotrophic Lateral Sclerosis

Hazem Ahmed, Rahel Wallimann, Achi Haider, Vahid Hosseini, Stefan Gruber, Marvin Robledo, Thi A.N. Nguyen, Adrienne Müller Herde, Irina Iten, Claudia Keller, Viola Vogel, Roger Schibli, Bernhard Wünsch, Linjing Mu and Simon M. Ametamey

J Nucl Med, 2021, 62, 259
DOI: 10.2967/jnumed.120.246785

A Systematic Review on Dementia and Translocator Protein (TSPO): When Nuclear Medicine Highlights an Underlying Expression

Miriam Conte, Maria Silvia De Feo, Ferdinando Corica, Joana Gorica, Marko Magdi Abdou Sidrak, Flaminia De Cristofaro, Luca Filippi, Maria Ricci, Giuseppe De Vincentis and Viviana Frantellizzi

Biomolecules, 2023, 13, 598
DOI: 10.3390/biom13040598

A Convenient Route to New (Radio)Fluorinated and (Radio)Iodinated Cyclic Tyrosine Analogs

Maria Chao, Jean-Michel Chezal, Eric Debiton, Damien Canitrot, Tiffany Witkowski, Sophie Levesque, Françoise Degoul, Sébastien Tarrit, Barbara Wenzel, Elisabeth Miot-Noirault, Audrey Serre and Aurélie Maisonial-Besset

Pharmaceuticals, 2022, 15, 162
DOI: 10.3390/ph15020162

Fluorine-18-Labeled Positron Emission Tomography Probe Targeting Activated p38α: Design, Synthesis, and In Vivo Evaluation in Rodents

Mikiya Futatsugi, Anna Miyazaki, Yasukazu Kanai, Naoya Kondo and Takashi Temma

Pharmaceuticals, 2025, 18, 600
DOI: 10.3390/ph18040600

Ethyl Pinacol Boronates as Advantageous Precursors for Copper-Mediated Radiofluorination

Nikolaos Hadjipaschalis, Sebastiano Ortalli, Zijun Chen, Robert S. Paton, Joseph Ford, Matthew Tredwell and Véronique Gouverneur

Org. Lett., 2025, 27, 6545
DOI: 10.1021/acs.orglett.5c02055

Mechanism of Cu-Catalyzed Aryl Boronic Acid Halodeboronation Using Electrophilic Halogen: Development of a Base-Catalyzed Iododeboronation for Radiolabeling Applications

John J. Molloy, Kerry M. O’Rourke, Carolina P. Frias, Nikki L. Sloan, Matthew J. West, Sally L. Pimlott, Andrew Sutherland and Allan J. B. Watson

Org. Lett., 2019, 21, 2488
DOI: 10.1021/acs.orglett.9b00942

Copper‐mediated nucleophilic radiofluorination of [18F]β‐CFT for positron emission tomography imaging of dopamine transporter

Hung‐Man Yu, Ching‐Yun Li, Shiu‐Wen Liu, Chun‐Hung Yang and Yu Chang

Labelled Comp Radiopharmac, 2021, 64, 228
DOI: 10.1002/jlcr.3905

Automated radiosynthesis and purification of [ 18 F]flumazenil with solid phase extraction

Daria Vaulina, Morteza Nasirzadeh and Natalia Gomzina

Applied Radiation and Isotopes, 2018, 135, 110
DOI: 10.1016/j.apradiso.2018.01.008

Optimization of 18F‐syntheses using 19F‐reagents at tracer‐level concentrations and liquid chromatography/tandem mass spectrometry analysis: Improved synthesis of [18F]MDL100907

Xiang Zhang, Ryan Dunlow, Burchelle N. Blackman and Rolf E. Swenson

Labelled Comp Radiopharmac, 2018, 61, 427
DOI: 10.1002/jlcr.3606

Characterization of (R)- and (S)-[18F]OF-NB1 in Rodents as Positron Emission Tomography Probes for Imaging GluN2B Subunit-Containing N-Methyl-d-Aspartate Receptors

Hazem Ahmed, Rahel Wallimann, Livio Gisler, Nehal H. Elghazawy, Stefan Gruber, Claudia Keller, Steven H. Liang, Wolfgang Sippl, Achi Haider and Simon M. Ametamey

ACS Chem. Neurosci., 2023, 14, 4323
DOI: 10.1021/acschemneuro.3c00519

Discovery and Evaluation of Imidazo[2,1-b][1,3,4]thiadiazole Derivatives as New Candidates for α-Synuclein PET Imaging

Qi Zeng, Xiaojun Zhang, Yuying Li, Qilei Zhang, Jiapei Dai, Xiao-xin Yan, Yu Liu, Jinming Zhang, Sen Liu and Mengchao Cui

J. Med. Chem., 2024, 67, 12695
DOI: 10.1021/acs.jmedchem.4c00686

Recent Advances in Photo‐mediated Radiofluorination

Tien Tan Bui and Hee‐Kwon Kim

Chemistry An Asian Journal, 2021, 16, 2155
DOI: 10.1002/asia.202100399

GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium–Glucose Cotransporter 2

Sjoukje van der Hoek, Inês F. Antunes, Khaled A. Attia, Olivier Jacquet, Andre Heeres, Marian Bulthuis, Rolf Zijlma, Hendrikus H. Boersma, Harry van Goor, Ton J. Visser, Hiddo J. L. Heerspink, Philip H. Elsinga and Jasper Stevens

J. Med. Chem., 2021, 64, 16641
DOI: 10.1021/acs.jmedchem.1c01269

GABAA Receptors in the Mongolian Gerbil: a PET Study Using [18F]Flumazenil to Determine Receptor Binding in Young and Old Animals

M. Kessler, M. Mamach, R. Beutelmann, M. Lukacevic, S. Eilert, P. Bascuñana, A. Fasel, F. M. Bengel, J. P. Bankstahl, T. L. Ross, G. M. Klump and G. Berding

Mol Imaging Biol, 2020, 22, 335
DOI: 10.1007/s11307-019-01371-0

Automation of the Radiosynthesis of Six Different 18F-labeled radiotracers on the AllinOne

Shihong Li, Alexander Schmitz, Hsiaoju Lee and Robert H. Mach

EJNMMI radiopharm. chem., 2017, 1
DOI: 10.1186/s41181-016-0018-0

Development of Customized [18F]Fluoride Elution Techniques for the Enhancement of Copper-Mediated Late-Stage Radiofluorination

Andrew V. Mossine, Allen F. Brooks, Naoko Ichiishi, Katarina J. Makaravage, Melanie S. Sanford and Peter J. H. Scott

Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-00110-1

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Nicholas J. Taylor, Enrico Emer, Sean Preshlock, Michael Schedler, Matthew Tredwell, Stefan Verhoog, Joel Mercier, Christophe Genicot and Véronique Gouverneur

J. Am. Chem. Soc., 2017, 139, 8267
DOI: 10.1021/jacs.7b03131

A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated 18F-Fluorination Reactions of Arylstannanes

Gregory D. Bowden, Bernd J. Pichler and Andreas Maurer

Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-47846-6

Closing the gap between 19F and 18F chemistry

Javier Ajenjo, Gianluca Destro, Bart Cornelissen and Véronique Gouverneur

EJNMMI radiopharm. chem., 2021, 6
DOI: 10.1186/s41181-021-00143-y

Selective Fluorination of Complex Molecules: Late-Stage Functionalization

Muyuan Wang, Jonah Ruskin, Joseph Marques, Nathaniel Garrison and Thomas Lectka

Chem. Rev., 2025
DOI: 10.1021/acs.chemrev.5c00363

Copper-mediated late-stage radiofluorination: five years of impact on preclinical and clinical PET imaging

Jay S. Wright, Tanpreet Kaur, Sean Preshlock, Sean S. Tanzey, Wade P. Winton, Liam S. Sharninghausen, Nicholas Wiesner, Allen F. Brooks, Melanie S. Sanford and Peter J. H. Scott

Clin Transl Imaging, 2020, 8, 167
DOI: 10.1007/s40336-020-00368-y

Evaluation of [18F]FMTEB in Sprague Dawley rats as a PET tracer for metabotropic glutamate receptor 5

Anna Krzyczmonik, Katharina E. Grafinger, Thomas Keller, Lukas Pfeifer, Sarita Forsback, Merja Haaparanta-Solin, Veronique Gouverneur, Francisco López-Picón and Olof Solin

Nuclear Medicine and Biology, 2023, 116-117, 108309
DOI: 10.1016/j.nucmedbio.2022.108309

Comparison of high and low molar activity TSPO tracer [18F]F-DPA in a mouse model of Alzheimer’s disease

Thomas Keller, Francisco R López-Picón, Anna Krzyczmonik, Sarita Forsback, Jatta S Takkinen, Johan Rajander, Simo Teperi, Frédéric Dollé, Juha O Rinne, Merja Haaparanta-Solin and Olof Solin

J Cereb Blood Flow Metab, 2020, 40, 1012
DOI: 10.1177/0271678X19853117

Mild, Organo-Catalysed Borono-Deamination as a Key to Late-Stage Pharmaceutical Precursors and 18F-Labelled Radiotracers

Raúl M. Pérez-García and Patrick J. Riss

Front. Chem., 2022, 10
DOI: 10.3389/fchem.2022.884478

Performing [18F]MFBG Long–Axial-Field-of-View PET/CT Without Sedation or General Anesthesia for Imaging of Children with Neuroblastoma

Lise Borgwardt, Jesper Brok, Kim Francis Andersen, Jacob Madsen, Nicholas Gillings, Marie Øbro Fosbøl, Charlotte Lund Denholt, Ida Nymann Petersen, Louise Sørup Sørensen, Lotte Hahn Enevoldsen, Peter Sandor Oturai, Helle Hjort Johannesen, Liselotte Højgaard, Christina Schulze, Eunice Saxtoft, Flemming Andersen and Barbara Malene Fischer

J Nucl Med, 2024, 65, 1286
DOI: 10.2967/jnumed.123.267256

Copper-Mediated Radiosynthesis of [18F]Rucaparib

Zijun Chen, Gianluca Destro, Florian Guibbal, Chung Ying Chan, Bart Cornelissen and Véronique Gouverneur

Org. Lett., 2021, 23, 7290
DOI: 10.1021/acs.orglett.1c02770

Synthesis and Characterization of 5-(2-Fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2

Gengyang Yuan, Maeva Dhaynaut, Yu Lan, Nicolas J. Guehl, Dalena Huynh, Suhasini M. Iyengar, Sepideh Afshar, Manish Kumar Jain, Julie E. Pickett, Hye Jin Kang, Hao Wang, Sung-Hyun Moon, Mary Jo Ondrechen, Changning Wang, Timothy M. Shoup, Georges El Fakhri, Marc D. Normandin and Anna-Liisa Brownell

J. Med. Chem., 2022, 65, 2593
DOI: 10.1021/acs.jmedchem.1c02004

Multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated 18F-fluorination

Thibault Gendron, Gianluca Destro, Natan J. W. Straathof, Jeroen B. I. Sap, Florian Guibbal, Charles Vriamont, Claire Caygill, John R. Atack, Andrew J. Watkins, Christopher Marshall, Rebekka Hueting, Corentin Warnier, Véronique Gouverneur and Matthew Tredwell

EJNMMI radiopharm. chem., 2022, 7
DOI: 10.1186/s41181-022-00158-z

Recent Progress in Nucleophilic Fluoride Mediated Fluorine-18 Labeling of Arenes and Heteroarenes

Yuan Zhu, Leyuan Chen, Wenbin Hou and Yiliang Li

Chinese Journal of Organic Chemistry, 2021, 1774
DOI: 10.6023/cjoc202010030

Radiosynthesis of [18F]flumazenil for imaging benzodiazepine receptors and its evaluation in human volunteers using simultaneous PET-MRI

Pardeep Kumar, Chandana Nagaraj, Raman Joshi, N. Sridhar Goud, Dinesh Kumar, Vittal Korann, Sandhya Mangalore and Naren P. Rao

J Radioanal Nucl Chem, 2021, 329, 581
DOI: 10.1007/s10967-021-07859-w

Optimization of Direct Aromatic 18F-Labeling of Tetrazines

Ida Vang Andersen, Rocío García-Vázquez, Umberto Maria Battisti and Matthias M. Herth

Molecules, 2022, 27, 4022
DOI: 10.3390/molecules27134022

(Radio)fluoroclick Reaction Enabled by a Hydrogen‐Bonding Cluster

Xiaojun Zeng, Junling Li, Chin K. Ng, Gerald B. Hammond and Bo Xu

Angew Chem Int Ed, 2018, 57, 2924
DOI: 10.1002/anie.201711341

Use of capillary electrophoresis for the determination of impurities in preparations of fluorine-18 labelled PET radiopharmaceuticals

Dmitrii Antuganov, Yulija Antuganova, Tatiana Zykova and Raisa Krasikova

Journal of Pharmaceutical and Biomedical Analysis, 2019, 173, 68
DOI: 10.1016/j.jpba.2019.05.016

Nucleophilic Synthesis of 6-l-[18F]FDOPA. Is Copper-Mediated Radiofluorination the Answer?

Raisa N. Krasikova

Molecules, 2020, 25, 4365
DOI: 10.3390/molecules25194365

Alcohol‐Enhanced Cu‐Mediated Radiofluorination

Johannes Zischler, Niklas Kolks, Daniel Modemann, Bernd Neumaier and Boris D. Zlatopolskiy

Chemistry A European J, 2017, 23, 3251
DOI: 10.1002/chem.201604633

In Vivo Veritas: 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors

Klas Bratteby, Edvard Torkelsson, Elina Tampio L’Estrade, Kristoffer Peterson, Vladimir Shalgunov, Mengfei Xiong, Hakon Leffler, Fredrik R. Zetterberg, Tomas G. Olsson, Nic Gillings, Ulf J. Nilsson, Matthias M. Herth and Maria Erlandsson

J. Med. Chem., 2020, 63, 747
DOI: 10.1021/acs.jmedchem.9b01692

Radiosynthesis of [18F]-flumazenil Using an Isotopic Approach

Riptee Thakur, Aishwarya Kumar, Raman Kumar Joshi and Pardeep Kumar

Indian Journal of Nuclear Medicine, 2024, 39, 286
DOI: 10.4103/ijnm.ijnm_82_24

Synthesis of high-molar-activity [18F]6-fluoro-l-DOPA suitable for human use via Cu-mediated fluorination of a BPin precursor

Andrew V. Mossine, Sean S. Tanzey, Allen F. Brooks, Katarina J. Makaravage, Naoko Ichiishi, Jason M. Miller, Bradford D. Henderson, Thomas Erhard, Christian Bruetting, Marc B. Skaddan, Melanie S. Sanford and Peter J. H. Scott

Nat Protoc, 2020, 15, 1742
DOI: 10.1038/s41596-020-0305-9

Ring-Closing Synthesis of Dibenzothiophene Sulfonium Salts and Their Use as Leaving Groups for Aromatic 18F-Fluorination

Thibault Gendron, Kerstin Sander, Klaudia Cybulska, Laure Benhamou, Pak Kwan Brian Sin, Aqsa Khan, Michael Wood, Michael J. Porter and Erik Årstad

J. Am. Chem. Soc., 2018, 140, 11125
DOI: 10.1021/jacs.8b06730

Transition-Metal-Mediated Radiohalogenation using Aryl Boron Reagents

Valeria K. Burianova, Holly McErlain and Andrew Sutherland

Synthesis, 2025, 57, 1402
DOI: 10.1055/s-0043-1775408

Effect of Pyridine Addition on the Efficiency of Copper‐Mediated Radiofluorination of Aryl Pinacol Boronates

Dmitrii Antuganov, Michail Zykov, Ksenija Timofeeva, Yulija Antuganova, Victoriya Orlovskaya and Raisa Krasikova

ChemistrySelect, 2017, 2, 7909
DOI: 10.1002/slct.201701628

Synthesis of a Pinacol Boronate Precursor for [18F]Rucaparib Radiosynthesis

Ju‐Ahn Seo, Jinjae Park and Cheol‐Hong Cheon

Asian J Org Chem, 2024, 13
DOI: 10.1002/ajoc.202300501

Efficient radiosynthesis and preclinical evaluation of [18F]FOMPyD as a positron emission tomography tracer candidate for TrkB/C receptor imaging

Thomas A. Singleton, Hussein Bdair, Justin J. Bailey, Sangho Choi, Arturo Aliaga, Pedro Rosa‐Neto, Ralf Schirrmacher, Vadim Bernard‐Gauthier and Alexey Kostikov

Labelled Comp Radiopharmac, 2020, 63, 144
DOI: 10.1002/jlcr.3827

Fragment-based labeling using condensation reactions of six potential 5-HT7R PET tracers

Elina Tampio L’Estrade, Vladimir Shalgunov, Szabolcs Lehel, Ida Nymann Petersen, Christian Bernard Matthijs Poulie, Fraser G. Edgar, Balázs Volk, Tomas Ohlsson, Maria Erlandsson, Gitte M. Knudsen and Matthias M. Herth

J Radioanal Nucl Chem, 2020, 326, 1749
DOI: 10.1007/s10967-020-07475-0

Defluoroborylation Reactions of Fluoroarenes

Takashi Niwa and Takamitsu Hosoya

J. Synth. Org. Chem. Jpn., 2019, 77, 883
DOI: 10.5059/yukigoseikyokaishi.77.883

A reliable and automated synthesis of 6-[18F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants

Zhengwei Zhang, Jingjie Ge, Kai Jing, Yefeng Chen, Yihui Guan, Hexin Xie and Jianhua Zhu

Med Chem Res, 2022, 31, 1126
DOI: 10.1007/s00044-022-02850-w

Facile 18F labeling of non-activated arenes via a spirocyclic iodonium(III) ylide method and its application in the synthesis of the mGluR5 PET radiopharmaceutical [18F]FPEB

Steven H. Liang, Lu Wang, Nickeisha A. Stephenson, Benjamin H. Rotstein and Neil Vasdev

Nat Protoc, 2019, 14, 1530
DOI: 10.1038/s41596-019-0149-3

Copper‐Mediated Radiofluorination of Aryl Pinacolboronate Esters: A Straightforward Protocol by Using Pyridinium Sulfonates

Dmitrii Antuganov, Michail Zykov, Vasilii Timofeev, Ksenija Timofeeva, Yulija Antuganova, Victoriya Orlovskaya, Olga Fedorova and Raisa Krasikova

Eur J Org Chem, 2019, 2019, 918
DOI: 10.1002/ejoc.201801514

Synthesis and Inhibitory Assessment of ACE2 Inhibitors for SARS-CoV-2: An In Silico and In Vitro Study

Xiaoyun Wang, Jieyu He, Layla Hosseini-Gerami, Morgan Thomas, Stephen Thompson, Joseph Ford, Sebastiano Ortalli, Zijun Chen, Gianluca Destro, Andreas Bender, Franklin Aigbirhio and Véronique Gouverneur

J. Org. Chem., 2025, 90, 10941
DOI: 10.1021/acs.joc.5c00918

Iridium‐Catalysed C−H Borylation of Heteroarenes: Balancing Steric and Electronic Regiocontrol

Jay S. Wright, Peter J. H. Scott and Patrick G. Steel

Angew Chem Int Ed, 2021, 60, 2796
DOI: 10.1002/anie.202001520

Triflyl [18F]Fluoride as a Solution for Base‐Sensitive Late‐Stage Nucleophilic Aromatic 18F‐Fluorination Reactions

Lizeth Y. F. Haveman, Anna M. T. de Kruijff, Sjoerd P. P. van Eeden, Albert D. Windhorst and Danielle J. Vugts

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202403127

Synthesis of [18F]Fluoroarenes by Nucleophilic Radiofluorination of N‐Arylsydnones

Maruthi Kumar Narayanam, Gaoyuan Ma, Pier Alexandre Champagne, Kendall N. Houk and Jennifer M. Murphy

Angew Chem Int Ed, 2017, 56, 13006
DOI: 10.1002/anie.201707274

Nucleophilic 18F‐Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors: Advantages and Disadvantages

Ida Nymann Petersen, Jesper Langgaard Kristensen and Matthias Manfred Herth

Eur J Org Chem, 2017, 2017, 453
DOI: 10.1002/ejoc.201601448

Selective Mu-Opioid Receptor Imaging Using 18F-Labeled Carfentanils

So Jeong Lee, Torben D. Pearson, Maeva Dhaynaut, Alexander C. MacDonagh, Hsiao-Ying Wey, Moses Q. Wilks, Bryan L. Roth, Jacob M. Hooker and Marc D. Normandin

J. Med. Chem., 2025, 68, 1632
DOI: 10.1021/acs.jmedchem.4c02287

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant 18F-Labelled σ2 Receptor Ligand

Rareş-Petru Moldovan, Daniel Gündel, Rodrigo Teodoro, Friedrich-Alexander Ludwig, Steffen Fischer, Magali Toussaint, Dirk Schepmann, Bernhard Wünsch, Peter Brust and Winnie Deuther-Conrad

IJMS, 2021, 22, 5447
DOI: 10.3390/ijms22115447

Cu‐Mediated Radiofluorination of Aryl Pinacolboronate Esters: Alcohols as Solvents with Application to 6‐L‐[18F]FDOPA Synthesis

Viktoriya Orlovskaya, Olga Fedorova, Olga Kuznetsova and Raisa Krasikova

Eur J Org Chem, 2020, 2020, 7079
DOI: 10.1002/ejoc.202001198

Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates

Songye Li, Zhengxin Cai, Xiaoai Wu, Daniel Holden, Richard Pracitto, Michael Kapinos, Hong Gao, David Labaree, Nabeel Nabulsi, Richard E. Carson and Yiyun Huang

ACS Chem. Neurosci., 2019, 10, 1544
DOI: 10.1021/acschemneuro.8b00526

18F-meta-fluorobenzylguanidine (18F-mFBG) to monitor changes in norepinephrine transporter expression in response to therapeutic intervention in neuroblastoma models

Stephen Turnock, David R. Turton, Carlos Daniel Martins, Louis Chesler, Thomas C. Wilson, Véronique Gouverneur, Graham Smith and Gabriela Kramer-Marek

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-77788-3

State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis

Lizeth Y. F. Haveman, Danielle J. Vugts and Albert D. Windhorst

EJNMMI radiopharm. chem., 2023, 8
DOI: 10.1186/s41181-023-00203-5

Manual and automated Cu-mediated radiosynthesis of the PARP inhibitor [18F]olaparib

Florian Guibbal, Patrick G. Isenegger, Thomas C. Wilson, Anna Pacelli, Damien Mahaut, Jeroen B. I. Sap, Nicholas J. Taylor, Stefan Verhoog, Sean Preshlock, Rebekka Hueting, Bart Cornelissen and Véronique Gouverneur

Nat Protoc, 2020, 15, 1525
DOI: 10.1038/s41596-020-0295-7

Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia

Maria Pannell, Vasiliki Economopoulos, Thomas C. Wilson, Veerle Kersemans, Patrick G. Isenegger, James R. Larkin, Sean Smart, Stuart Gilchrist, Véronique Gouverneur and Nicola R. Sibson

Glia, 2020, 68, 280
DOI: 10.1002/glia.23716

18F-Fluorination: Challenge and Opportunity for Organic Chemists

Riya Halder and Tobias Ritter

J. Org. Chem., 2021, 86, 13873
DOI: 10.1021/acs.joc.1c01474

Development of 18F-Labeled Radiotracers for PET Imaging of the Adenosine A2A Receptor: Synthesis, Radiolabeling and Preliminary Biological Evaluation

Thu Hang Lai, Susann Schröder, Magali Toussaint, Sladjana Dukić-Stefanović, Mathias Kranz, Friedrich-Alexander Ludwig, Steffen Fischer, Jörg Steinbach, Winnie Deuther-Conrad, Peter Brust and Rareş-Petru Moldovan

IJMS, 2021, 22, 2285
DOI: 10.3390/ijms22052285

Synthesis and in vitro evaluation of spirobenzovesamicols as potential 11C-PET tracer alternatives to [18F]FEOBV for vesicular acetylcholine transporter (VAChT) imaging

Hugo Helbert, Winnie Deuther-Conrad, Michel de Haan, Barbara Wenzel, Gert Luurtsema, Wiktor Szymanski, Peter Brust, Rudi A. J. O. Dierckx, Ben L. Feringa and Philip H. Elsinga

EJNMMI radiopharm. chem., 2025, 10
DOI: 10.1186/s41181-025-00327-w

Radiosynthesis and Biodistribution of 18F-Linezolid in Mycobacterium tuberculosis-Infected Mice Using Positron Emission Tomography

Filipa Mota, Ravindra Jadhav, Camilo A. Ruiz-Bedoya, Alvaro A. Ordonez, Mariah H. Klunk, Joel S. Freundlich and Sanjay K. Jain

ACS Infect. Dis., 2020, 6, 916
DOI: 10.1021/acsinfecdis.9b00473

Cardiac Sympathetic Positron Emission Tomography Imaging with Meta-[18F]Fluorobenzylguanidine is Sensitive to Uptake-1 in Rats

Uzair S. Ismailani, Ariel Buchler, Gedaliah Farber, Aleksandra Pekošak, Eadan Farber, Nicole MacMullin, Erik J. Suuronen, Neil Vasdev, Rob S. B. Beanlands, Robert A. de Kemp and Benjamin H. Rotstein

ACS Chem. Neurosci., 2021, 12, 4350
DOI: 10.1021/acschemneuro.1c00575

One‐step synthesis of [18F]cabozantinib for use in positron emission tomography imaging of c‐Met

Vegard Torp Lien, Jo Klaveness and Dag Erlend Olberg

Labelled Comp Radiopharmac, 2018, 61, 11
DOI: 10.1002/jlcr.3564

Practical Synthesis of [18F]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography

Takayoshi Nakaoka, Yuta Uetake, Ken-ichi Kaneko, Takashi Niwa, Hidenori Ochiai, Satsuki Irie, Yoshie Suezaki, Natsumi Otsuka, Emi Hayashinaka, Yasuhiro Wada, Yilong Cui, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama, Takamitsu Hosoya and Yasuyoshi Watanabe

Mol. Pharmaceutics, 2020, 17, 1884
DOI: 10.1021/acs.molpharmaceut.9b01284

Control of reactivity and selectivity of guanidinyliodonium salts toward 18F-Labeling by monitoring of protecting groups: Experiment and theory

Keun Sam Jang, Sung-Sik Lee, Young-Ho Oh, Sang Hee Lee, Sang Eun Kim, Dong Wook Kim, Byung Chul Lee, Sungyul Lee and David M. Raffel

Journal of Fluorine Chemistry, 2019, 227, 109387
DOI: 10.1016/j.jfluchem.2019.109387

Synthesis and Preclinical Evaluation of 2-(4-[18F]Fluorophenyl)imidazo[1,2-h][1,7]naphthyridine ([18F]FPND-4): An Aza-Fused Tricyclic Derivative as Positron Emission Tomography Tracer for Neurofibrillary Tangle Imaging

Tianqing Liu, Yuying Li, Xiaojun Zhang, An Yao, Yan Wang, Shulin Yao, Baian Chen, Xiao-xin Yan, Jiapei Dai, Jinming Zhang and Mengchao Cui

J. Med. Chem., 2023, 66, 9561
DOI: 10.1021/acs.jmedchem.3c00239