Strategic Advances in C–OCF3 Bond Transformations

Abstract

While synthetic developments for the synthesis of trifluoromethoxylated arenes have flourished over the years, the cleavage of a C-OCF3 bond remains a niche topic and a synthetic challenge to overcome. This highlight provides an overview of major advances made in activating a strong aryl C–OCF3 bond, enabling C–C, C–H, and C–Heteroatom bond formations. These advances underscore the transformative potential of further developments in this emerging field.