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New S-doped yttrium oxide ultrathin nanosheets (NSs) were synthesized which had good electrochemiluminescence (ECL) properties. Through combining these NSs with small molecule linked DNA as the substrate, a novel ECL biosensor was constructed for the detection of protein biomarkers with an acceptable performance.

Graphical abstract: A novel electrochemiluminescence biosensor based on S-doped yttrium oxide ultrathin nanosheets for the detection of anti-Dig antibodies

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