Recent advances in the total synthesis of polycyclic phloroglucinol natural products

Abstract

The total synthesis of polycyclic phloroglucinol natural products has attracted significant attention from the chemistry community in recent years, owing to their challenging structural frameworks and wide range of biological activities. The synthesis of polycyclic phloroglucinol natural products presents considerable challenges, requiring the development of innovative strategies. Recently, a range of elegant synthetic approaches have been developed to access polycyclic phloroglucinol natural products, including Diels–Alder cycloadditions, cascade reactions, metal catalysis and other advanced methodologies. In this review, we provide a brief summary of the recent advancements in synthetic strategies targeting polycyclic phloroglucinol natural products, as well as their isolation and biological activities.