Rhodium-catalyzed hydroselenation of unsymmetric 1,3-dienes with 3,4-Markovnikov regioselectivity

Abstract

Catalytic hydroselenation of alkenes represents one of the most direct and efficient methods for organoselenide synthesis. In this study, we report a highly regioselective Rh-catalyzed hydroselenation of unsymmetric 1,3-dienes, including internal unsymmetric dienes. This atom-economical method operates under mild conditions and selectively affords 3,4-Markovnikov products with excellent regiocontrol. The developed protocol was effective in reactions involving both internal and terminal dienes.